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Steroids and sterols

11-Deoxycortisol

Also known as Cortodoxone, Reichstein's substance S, 11-Deoxyhydrocortisone

CAS 152-58-9Formula C21H30O4Molar mass 346.47 g/molEC 205-805-2
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 41 suppliers listed
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11-Deoxycortisol chemical structure, C21H30O4, CAS 152-58-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
152-58-9
Formula
C21H30O4
Molar mass
346.47 g/mol
EC number
205-805-2
HS code
291440
Category
Steroids and sterols

What is 11-Deoxycortisol?

Plain description, key identifiers and synonyms

11-deoxycortisol is a deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen. It has a role as a mouse metabolite and a human metabolite. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a deoxycortisol and a glucocorticoid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS number
152-58-9 CAS number cross-checked
EC number
205-805-2
Molecular formula
C21H30O4
UNII
WDT5SLP0HQ
MDL number
MFCD00003662
InChIKey
WHBHBVVOGNECLV-OBQKJFGGSA-N
InChI
InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
Canonical SMILES
CC12CCC(=O)C=C1CCC1C2CCC2(C)C1CCC2(O)C(=O)CO
Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C

Synonyms

  • Cortodoxone
  • Reichstein's substance S
  • 11-Deoxyhydrocortisone
  • 17,21-Dihydroxyprogesterone
  • Cortisol, 11-deoxy-
  • 11-Deoxy-17-hydroxycorticosterone
  • 11-deoxycortisone
  • 11-Desoxyhydrocortisone
  • 17alpha-Hydroxycortexone
  • 17-Hydroxy-11-deoxycorticosterone
  • Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
  • 11-Desoxycortisone
  • SK&F 3050
  • 11-Desoxy-17-hydroxycorticosterone
  • 11 Deoxycortisol
  • 17-alpha-Hydroxycortexone
  • 4-Pregnene-17alpha,21-diol-3,20-dione
  • Skf-3050
  • Substance S, Reichstein's
  • SK&F-3050
  • (8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • 11 Desoxycortisol
  • 11 Desoxycortisone
  • Reichstein Substance S
  • (1S,2R,10R,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadec-6-en-5-one
Show all 38 synonyms
  • (1S,2R,10R,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
  • (8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta(a)phenanthren-3-one
  • Reichsteins Substance S
  • Cortexolone
  • 11-Desoxycortisol
  • Reichstein S
  • Reichstein's compound S
  • 11-Dioxycortisol
  • 11-Deoxy Cortisol
  • Cortodoxona
  • Cortifen
  • Cortodoxonum
  • 17,21-Dihydroxy-4-pregnene-3,20-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
346.47 g/molcalc.
Exact mass
346.2144 Dacalc.
LogP (octanol/water)
2.81calc.
Topological polar surface area
74.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
25calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.81calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CCC3C2CC1

O=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

1,419 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H341Suspected of causing genetic defects.
  • H351Suspected of causing cancer.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

11-Deoxycortisol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 41 suppliers
30 of 30 offers

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Where suppliers are based

41 suppliers in 11 countries

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11-Deoxycortisol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite

Pharmacology

Cortodoxone is a glucocorticoid that is an intermediate in the biosynthesis of cortisol in the adrenal gland.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 11-Deoxycortisol is traded under.

HS 2914.40Indicative HS code

Ketone-alcohols and ketone-aldehydes

World exports in 2024
$199M
+2.5% vs 2023, imports $247M
2019 to 2024
Top exporters
  1. China29.5%
  2. Germany14.4%
  3. Netherlands12.7%
Top importers
  1. United States37.2%
  2. Netherlands8.5%
  3. Germany6.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 11-Deoxycortisol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 11-Deoxycortisol, based on the data on this page

What is 11-Deoxycortisol?

11-deoxycortisol is a deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen. It has a role as a mouse metabolite and a human metabolite. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a deoxycortisol and a glucocorticoid.

What is the CAS number of 11-Deoxycortisol?

The CAS registry number of 11-Deoxycortisol is 152-58-9.

What is the molecular formula and weight of 11-Deoxycortisol?

The molecular formula of 11-Deoxycortisol is C21H30O4 and its molar mass is 346.47 g/mol.

What is 11-Deoxycortisol used for?

Known uses and roles of 11-Deoxycortisol include animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite, metabolite and 1 more.

Is 11-Deoxycortisol hazardous?

11-Deoxycortisol carries the GHS signal word "Warning". Main hazards: harmful if swallowed, suspected of causing genetic defects, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 11-Deoxycortisol?

11-Deoxycortisol is usually classified under HS code 291440 (Ketone-alcohols and ketone-aldehydes). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 11-Deoxycortisol?

CompoundList lists 41 suppliers of 11-Deoxycortisol in China, United States, United Kingdom, Canada and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 11-Deoxycortisol?

Suppliers quote 11-Deoxycortisol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 11-Deoxycortisol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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