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Hormones and steroids

17-Hydroxyprogesterone

Also known as hydroxyprogesterone, 17Alpha-hydroxyprogesterone, Prodix

CAS 68-96-2Formula C21H30O3Molar mass 330.47 g/molEC 200-699-4
GHS signal word: Danger. Pictograms: Serious health hazard 83 suppliers listed Drug substance
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17-Hydroxyprogesterone chemical structure, C21H30O3, CAS 68-96-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
68-96-2
Formula
C21H30O3
Appearance
Rhombic or hexagonal leaflets from acetone or alcohol
Melting point
222 to 223
HS code
293723
Category
Hormones and steroids
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is 17-Hydroxyprogesterone?

Plain description, key identifiers and synonyms

17alpha-hydroxyprogesterone is a 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone. It has a role as a metabolite, a progestin, a mouse metabolite and a human metabolite. It is a 17alpha-hydroxy-C21-steroid, a tertiary alpha-hydroxy ketone and a 17alpha-hydroxy steroid. It is functionally related to a progesterone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS number
68-96-2 CAS number cross-checkedOther or deprecated CAS: 110850-01-6
EC number
200-699-4
Molecular formula
C21H30O3
UNII
21807M87J2
MDL number
MFCD00003659
InChIKey
DBPWSSGDRRHUNT-CEGNMAFCSA-N
InChI
InChI=1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
Canonical SMILES
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C
Isomeric SMILES
CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O

Synonyms

  • hydroxyprogesterone
  • 17Alpha-hydroxyprogesterone
  • Prodix
  • Prodox
  • Gestageno gador
  • 17-alpha-Hydroxyprogesterone
  • 17-Hydroxypregn-4-ene-3,20-dione
  • Gestageno
  • Hidroxiprogesterona
  • Hydroxyprogesteronum
  • 17alpha-Hydroxy-4-pregnene-3,20-dione
  • 17-OH Progesterone
  • delta(4)-Pregnene-17alpha-ol-3,20-dione
  • 17alpha-Hydroxy-progesterone
  • Pregn-4-ene-3,20-dione-17-ol
  • Idrossiprogesterone
  • alpha Hydroxy progesterone
  • 17-Hydroxypregn-4-en-3,20-dione
  • (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • 17 Hydroxyprogesterone
  • 17 alpha Hydroxyprogesterone
  • 17 alpha-Hydroxyprogesterone
  • (1S,2R,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,15-dimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadec-6-en-5-one
  • (1S,2R,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
  • (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta(a)phenanthren-3-one
Show all 34 synonyms
  • 17-Hydroxyprogesterone, (17 alpha)-
  • (1S,2R,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,15-dimethyltetracyclo(8.7.0.02,7.011,15)heptadec-6-en-5-one
  • 17a-Hydroxyprogesterone
  • 17|A-Hydroxyprogesterone
  • Pregn-4-ene-3,20-dione, 17-hydroxy-
  • Setaderm
  • Oxiprogesteronum
  • 4-Pregnen-17a-ol-3,20-dione
  • 17?-Hydroxyprogesterone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Rhombic or hexagonal leaflets from acetone or alcoholexp.
Melting point
222 to 223exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
330.47 g/molcalc.
Exact mass
330.2195 Dacalc.
LogP (octanol/water)
3.84calc.
Topological polar surface area
54.37 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
24calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.81calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CCC3C2CC1

O=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

1,419 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H360May damage fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

17-Hydroxyprogesterone suppliers

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All 83 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

83 suppliers in 15 countries

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17-Hydroxyprogesterone price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Roles

  • agonist
  • animal metabolite
  • eukaryotic metabolite
  • hormone
  • human metabolite
  • mammalian metabolite
  • metabolite
  • molecular messenger
  • mouse metabolite
  • progestin
  • progestogen
  • sex hormone

Pharmacology

Hydroxyprogesterone is a Progestin.

How it is made

Hydroxyprogesterone is esterified by heating with caproic anhydride in presence of p-toluene-sulfonic acid under atmosphere of nitrogen. Us patent 2,753,360. (Caproate)

Julian et al, us patent 2,648,662 (1953 to glidden)...stork et al, us patents 2,802,839 & 2,805,203 (both 1957 to syntex)...dulaney, mcaleer, us patents 2,777,843, 2,786,856/7, 2,813,060 (all 1957 to merck & co)...pederson, us patent 3,000,883 (1961 to upjohn).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 17-Hydroxyprogesterone is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 17-Hydroxyprogesterone is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 17-Hydroxyprogesterone, based on the data on this page

What is 17-Hydroxyprogesterone?

17alpha-hydroxyprogesterone is a 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone. It has a role as a metabolite, a progestin, a mouse metabolite and a human metabolite. It is a 17alpha-hydroxy-C21-steroid, a tertiary alpha-hydroxy ketone and a 17alpha-hydroxy steroid.

What is the CAS number of 17-Hydroxyprogesterone?

The CAS registry number of 17-Hydroxyprogesterone is 68-96-2. Other or deprecated CAS numbers: 110850-01-6.

What is the molecular formula and weight of 17-Hydroxyprogesterone?

The molecular formula of 17-Hydroxyprogesterone is C21H30O3 and its molar mass is 330.47 g/mol.

What is 17-Hydroxyprogesterone used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is 17-Hydroxyprogesterone hazardous?

17-Hydroxyprogesterone carries the GHS signal word "Danger". Main hazards: may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 17-Hydroxyprogesterone?

17-Hydroxyprogesterone is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 17-Hydroxyprogesterone?

CompoundList lists 83 suppliers of 17-Hydroxyprogesterone in China, United States, Germany, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 17-Hydroxyprogesterone in India?

3 suppliers in India list 17-Hydroxyprogesterone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 17-Hydroxyprogesterone?

Suppliers quote 17-Hydroxyprogesterone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 17-Hydroxyprogesterone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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