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Steroids and sterols

Corticosterone

Also known as 17-Deoxycortisol, Reichstein's substance H, Kendall's compound B

CAS 50-22-6Formula C21H30O4Molar mass 346.47 g/molEC 200-019-6
GHS signal word: Warning. Pictograms: Harmful or irritant 67 suppliers listed
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Corticosterone chemical structure, C21H30O4, CAS 50-22-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
50-22-6
Formula
C21H30O4
Molar mass
346.47 g/mol
EC number
200-019-6
HS code
291440
Category
Steroids and sterols

What is Corticosterone?

Plain description, key identifiers and synonyms

Corticosterone is a 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. It has a role as a mouse metabolite and a human metabolite. It is a primary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid. It derives from a hydride of a pregnane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CAS number
50-22-6 CAS number cross-checked
EC number
200-019-6
Molecular formula
C21H30O4
UNII
W980KJ009P
MDL number
MFCD00037715
InChIKey
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
InChI
InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
Canonical SMILES
CC12CCC(=O)C=C1CCC1C2C(O)CC2(C)C(C(=O)CO)CCC12
Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O

Synonyms

  • 17-Deoxycortisol
  • Reichstein's substance H
  • Kendall's compound B
  • Corticosteron
  • 11beta,21-Dihydroxyprogesterone
  • (11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione
  • 11Beta,21-dihydroxypregn-4-ene-3,20-dione
  • 11beta,21-Dihydroxy-4-pregnene-3,20-dione
  • 4-Pregnene-11beta,21-diol-3,20-dione
  • (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one
  • Reichstein's B
  • 11-Hydroxycorticoaldosterone
  • 11,21-Dihydroxyprogesterone
  • 11-beta,21-Dihydroxypregn-3,20-dione
  • 4-Pregnene-11-beta,21-diol-3,20-dione
  • Corticosterone (Standard)
  • Pregn-4-ene-3,20-dione, 11beta,21-dihydroxy-
  • Pregn-4-ene-3,20-dione, 11-beta,21-dihydroxy-
  • (11-beta)-11,21-Dihydroxypregn-4-ene-3,20-dione
  • (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
  • 11,12-Dihydroxyprogesterone
  • 11-beta,21-Dihydroxyprogesterone
  • Compound B nach Kendall
  • Substanz H nach Reichstein
Show all 32 synonyms
  • Cortico
  • Compd B
  • Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11b)-
  • (11-Beta)-11,21-dihydroxy-pregn-4-ene-3,20-dione
  • Corticosterone, >=92%
  • 11-beta,20-dione
  • 17-Deoxycortisol(Standard)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
346.47 g/molcalc.
Exact mass
346.2144 Dacalc.
LogP (octanol/water)
2.67calc.
Topological polar surface area
74.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
25calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.81calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CCC3C2CC1

O=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

1,419 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H317May cause an allergic skin reaction.
Precautionary statements (8)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Corticosterone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 67 suppliers
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Where suppliers are based

67 suppliers in 12 countries

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Corticosterone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Inflammatory Agents

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite

Pharmacology

Corticosterone is a corticosteroid intermediate in the steroidogenic pathway that converts pregnenolone to aldosterone. In humans, corticosterone has limited glucocorticoid or mineralocorticoid activity.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Corticosterone is traded under.

HS 2914.40Indicative HS code

Ketone-alcohols and ketone-aldehydes

World exports in 2024
$199M
+2.5% vs 2023, imports $247M
2019 to 2024
Top exporters
  1. China29.5%
  2. Germany14.4%
  3. Netherlands12.7%
Top importers
  1. United States37.2%
  2. Netherlands8.5%
  3. Germany6.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Corticosterone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Corticosterone, based on the data on this page

What is Corticosterone?

Corticosterone is a 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.

What is the CAS number of Corticosterone?

The CAS registry number of Corticosterone is 50-22-6.

What is the molecular formula and weight of Corticosterone?

The molecular formula of Corticosterone is C21H30O4 and its molar mass is 346.47 g/mol.

What is Corticosterone used for?

Use classes: Pharmaceuticals.

Is Corticosterone hazardous?

Corticosterone carries the GHS signal word "Warning". Main hazards: may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Corticosterone?

Corticosterone is usually classified under HS code 291440 (Ketone-alcohols and ketone-aldehydes). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Corticosterone?

CompoundList lists 67 suppliers of Corticosterone in United States, China, United Kingdom, Germany and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Corticosterone?

Suppliers quote Corticosterone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Corticosterone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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