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Analgesics and anti-inflammatories

Cortisone

Also known as Kendall's compound E, Reichstein's substance FA, Wintersteiner's compound F

CAS 53-06-5Formula C21H28O5Molar mass 360.45 g/molEC 200-162-4
GHS signal word: Warning. Pictograms: Serious health hazard 51 suppliers listed Drug substance
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Cortisone chemical structure, C21H28O5, CAS 53-06-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
53-06-5
Formula
C21H28O5
Molar mass
360.45 g/mol
EC number
200-162-4
HS code
293721
Category
Analgesics and anti-inflammatories

What is Cortisone?

Plain description, key identifiers and synonyms

Cortisone is a C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20. It has a role as a mouse metabolite and a human metabolite. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, an 11-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid. It derives from a hydride of a pregnane.

Cortisone is a biologically inactive metabolite produced in the liver by the action of the enzyme 11β-hydroxysteroid dehydrogenase from cortisol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
CAS number
53-06-5 CAS number cross-checked
EC number
200-162-4
Molecular formula
C21H28O5
UNII
V27W9254FZ
MDL number
MFCD00003610
InChIKey
MFYSYFVPBJMHGN-ZPOLXVRWSA-N
InChI
InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
Canonical SMILES
CC12CCC(=O)C=C1CCC1C2C(=O)CC2(C)C1CCC2(O)C(=O)CO
Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C

Synonyms

  • Kendall's compound E
  • Reichstein's substance FA
  • Wintersteiner's compound F
  • 17-Hydroxy-11-dehydrocorticosterone
  • 11-Dehydro-17-hydroxycorticosterone
  • Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-
  • Cortisona
  • 17,21-Dihydroxypregn-4-ene-3,11,20-trione
  • Cortisonum
  • Kortison
  • 4-Pregnene-17alpha,21-diol-3,11,20-trione
  • 17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione
  • Pregn-4-en-17alpha,21-diol-3,11,20-trione
  • 17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione
  • (1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-5,17-dione
  • (1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadec-6-ene-5,17-dione
  • Therapeutic Cortisone
  • Cortisonum 30 Special Order
  • Cortivite
  • Adrenalex
  • Andreson
  • Cortisal
  • Cortistal
  • Reichstein Fa
  • Cortandren
Show all 34 synonyms
  • Cortison
  • Kendall's compound
  • [3H]-cortisone
  • 17alpha-Hydroxy-11-dehydrocorticosterone
  • (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
  • delta(sup4)-pregnene-17alpha,21-diol-3,11,20-trione
  • [3H]cortisone
  • Cortisone (INN)
  • 17,21-Dihydroxy-pregn-4-ene-3,11,20-trione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
360.45 g/molcalc.
Exact mass
360.1937 Dacalc.
LogP (octanol/water)
1.99calc.
Topological polar surface area
91.67 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
26calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.76calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CC(=O)C3C2CC1

O=C1C=C2CCC3C4CCCC4CC(=O)C3C2CC1

4 rings, 19 atoms.

106 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cortisone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 51 suppliers
30 of 30 offers
  • Chemcopia
    India ManufacturerUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
    View
  • Enomark Pharma
    India ManufacturerUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
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  • Phenomenex
    Australia, Sydney ManufacturerUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
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  • 10X Chem
    United States, San DiegoUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
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  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
    View
  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
    View
  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
    View
  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
    View
  • ABCR GmbH & CO. KG
    GermanyUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
    View
  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    CortisoneGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

51 suppliers in 14 countries

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Cortisone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Calculated removal (%): 45.8.

Use classes: Steroid hormones, Pharmaceuticals.

Pharmacological actions

  • Anti-Inflammatory Agents

Roles

  • analgesic
  • animal metabolite
  • anti-inflammatory agent
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite
  • pharmaceutical

Pharmacology

Cortisone is a Corticosteroid. The mechanism of action of cortisone is as a Corticosteroid Hormone Receptor Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cortisone is traded under.

HS 2937.21Exact HS code

Cortisone, hydrocortisone, prednisone (dehydrocortisone) and prednisolone…

World exports in 2024
$252M
−5.8% vs 2023, imports $242M
2019 to 2024
Top exporters
  1. China62.1%
  2. Italy9.6%
  3. United States9.4%
Top importers
  1. India * partner reported17.2%
  2. United States10.1%
  3. Italy8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cortisone is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cortisone, based on the data on this page

What is Cortisone?

Cortisone is a C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20. It has a role as a mouse metabolite and a human metabolite.

What is the CAS number of Cortisone?

The CAS registry number of Cortisone is 53-06-5.

What is the molecular formula and weight of Cortisone?

The molecular formula of Cortisone is C21H28O5 and its molar mass is 360.45 g/mol.

What is Cortisone used for?

Calculated removal (%): 45.8. Use classes: Steroid hormones, Pharmaceuticals.

Is Cortisone hazardous?

Cortisone carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cortisone?

Cortisone is usually classified under HS code 293721 (Cortisone, hydrocortisone, prednisone (dehydrocortisone) and prednisolone…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cortisone?

CompoundList lists 51 suppliers of Cortisone in United States, China, United Kingdom, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cortisone in India?

2 suppliers in India list Cortisone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cortisone?

Suppliers quote Cortisone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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