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Steroids and sterols

16-Hydroxyestrone

Also known as 16-alpha-hydroxyestrone, (8R,9S,13S,14S)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one, Estra-1,3,5(10)-trien-17-one, 3,16-dihydroxy-

CAS 18186-49-7Formula C18H22O3Molar mass 286.37 g/mol
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16-Hydroxyestrone chemical structure, C18H22O3, CAS 18186-49-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
18186-49-7
Formula
C18H22O3
Molar mass
286.37 g/mol
HS code
291450
Category
Steroids and sterols

What is 16-Hydroxyestrone?

Plain description, key identifiers and synonyms

16-Hydroxyestrone is a chemical substance with the molecular formula C18H22O3 and a molar mass of 286.37 g/mol. Its CAS registry number is 18186-49-7. The IUPAC name is (8R,9S,13S,14S)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,13S,14S)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
CAS number
18186-49-7 CAS number cross-checked
Molecular formula
C18H22O3
InChIKey
WPOCIZJTELRQMF-DIQFNYNJSA-N
InChI
InChI=1S/C18H22O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-16,19-20H,2,4,6-7,9H2,1H3/t13-,14-,15+,16?,18+/m1/s1
Canonical SMILES
CC12CCC3c4ccc(O)cc4CCC3C1CC(O)C2=O
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC(C2=O)O)CCC4=C3C=CC(=C4)O

Synonyms

  • 16-alpha-hydroxyestrone
  • (8R,9S,13S,14S)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
  • Estra-1,3,5(10)-trien-17-one, 3,16-dihydroxy-
  • 3,16-Dihydroxyestra-1,3,5(10)-trien-17-one #
  • 3,16-Dihydroxyestra-1(10),2,4-trien-17-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
286.37 g/molcalc.
Exact mass
286.1569 Dacalc.
LogP (octanol/water)
2.79calc.
Topological polar surface area
57.53 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
21calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C1CCC1c3ccccc3CCC12

O=C1CCC2C1CCC1c3ccccc3CCC12

4 rings, 18 atoms.

176 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

16-Hydroxyestrone suppliers

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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

1 supplier in 1 country

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16-Hydroxyestrone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 16-Hydroxyestrone is traded under.

HS 2914.50Indicative HS code

Ketone-phenols and ketones with other oxygen function

World exports in 2024
$438M
+10.9% vs 2023, imports $420M
2019 to 2024
Top exporters
  1. China50.5%
  2. India * partner reported11.6%
  3. United States11.3%
Top importers
  1. United States20.8%
  2. Germany10.0%
  3. Netherlands8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 16-Hydroxyestrone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 16-Hydroxyestrone, based on the data on this page

What is 16-Hydroxyestrone?

16-Hydroxyestrone is a chemical substance with the molecular formula C18H22O3 and a molar mass of 286.37 g/mol. Its CAS registry number is 18186-49-7. The IUPAC name is (8R,9S,13S,14S)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one.

What is the CAS number of 16-Hydroxyestrone?

The CAS registry number of 16-Hydroxyestrone is 18186-49-7.

What is the molecular formula and weight of 16-Hydroxyestrone?

The molecular formula of 16-Hydroxyestrone is C18H22O3 and its molar mass is 286.37 g/mol.

Is 16-Hydroxyestrone hazardous?

No GHS hazard classification for 16-Hydroxyestrone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of 16-Hydroxyestrone?

16-Hydroxyestrone is usually classified under HS code 291450 (Ketone-phenols and ketones with other oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 16-Hydroxyestrone?

CompoundList lists 1 supplier of 16-Hydroxyestrone in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 16-Hydroxyestrone?

Suppliers quote 16-Hydroxyestrone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 16-Hydroxyestrone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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