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Hormones and steroids

Estrone

Also known as folliculin, Theelin, estrovarin

CAS 53-16-7Formula C18H22O2Molar mass 270.37 g/molEC 200-164-5
GHS signal word: Danger. Pictograms: Serious health hazard 98 suppliers listed Drug substance
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Estrone chemical structure, C18H22O2, CAS 53-16-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Small, white crystals, or white to creamy white, crystalline powder
Melting point
260.2 °C
Density
1.236 g/cm³ at 25 °C
Solubility
In double-distilled water, 12.42 mg/L
HS code
293723
Category
Hormones and steroids
Illustrative photo, off-white crystalline powder with an amber glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Estrone?

Plain description, key identifiers and synonyms

Estrone is a 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17. It has a role as an antineoplastic agent, an estrogen, a bone density conservation agent, a mouse metabolite and a human metabolite. It is a phenolic steroid, a 17-oxo steroid, a member of phenols and a 3-hydroxy steroid. It derives from a hydride of an estrane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
CAS number
53-16-7 CAS number cross-checkedOther or deprecated CAS: 19973-76-3
EC number
200-164-5
Molecular formula
C18H22O2
UNII
2DI9HA706A, X9XKA379T9
MDL number
MFCD00003620
InChIKey
DNXHEGUUPJUMQT-CBZIJGRNSA-N
InChI
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
Canonical SMILES
CC12CCC3c4ccc(O)cc4CCC3C1CCC2=O
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)O

Synonyms

  • folliculin
  • Theelin
  • estrovarin
  • Thelykinin
  • Kestrone
  • Ketohydroxyestrin
  • Estrugenone
  • Tokokin
  • Follicunodis
  • Disynformon
  • Glandubolin
  • Hiestrone
  • Oestroform
  • Oestroperos
  • Estron
  • Femidyn
  • Folipex
  • Folisan
  • Kolpon
  • Menagen
  • Oestrin
  • 1,3,5(10)-Estratrien-3-ol-17-one
  • Endofolliculina
  • Aquacrine
  • Crinovaryl
Show all 39 synonyms
  • Cristallovar
  • Crystogen
  • Hormofollin
  • Hormovarine
  • Ketodestrin
  • Menformon
  • Oestronum
  • Ovifollin
  • Thelestrin
  • Wynestron
  • Destrone
  • Estrusol
  • Perlatan
  • 3-Hydroxyestra-1,3,5(10)-trien-17-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Small, white crystals, or white to creamy white, crystalline powderexp.
Odour
Odorlessexp.
Melting point
260.2 °Cexp.
Density
1.236 g/cm³ at 25 °Cexp.
Solubility
In double-distilled water, 12.42 mg/Lexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
270.37 g/molcalc.
Exact mass
270.162 Dacalc.
LogP (octanol/water)
3.82calc.
Topological polar surface area
37.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
20calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C1CCC1c3ccccc3CCC12

O=C1CCC2C1CCC1c3ccccc3CCC12

4 rings, 18 atoms.

176 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H350May cause cancer.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H360FDMay damage fertility. May damage the unborn child.
  • H362May cause harm to breast-fed children.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Estrone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 98 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

98 suppliers in 17 countries

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Estrone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

In the preparation of commercial 19-norsteriods.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Estrogens

Roles

  • agonist
  • animal metabolite
  • anti-obesity agent
  • antineoplastic agent
  • bone density conservation agent
  • estrogen
  • eukaryotic metabolite
  • hormone
  • human metabolite
  • mammalian metabolite
  • metabolite
  • molecular messenger
  • mouse metabolite
  • pharmaceutical
  • sex hormone

Pharmacology

Therapeutic Estrone is the synthetic form of a naturally occurring estrogen estrone. Estrone diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated hormone-receptor complex gets translocated to the nucleus where it binds to the estrogen response element on the DNA and promotes the transcription of target genes involved in the functioning of the female reproductive system and secondary sex characteristics.

Read more

Estrone increases the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins, as well as suppresses the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.

How it is made

From mexican yam (Dioscorea Mexicana) ... via 16-dehydropregnenolone acetate ... side chain at position-17 ... degraded by ... forming 2-oxime and then ... Beckmann rearrangement with p-acetamidobenzenesulfonyl chloride to 17-acetamido ... which ... with ... sulfuric ... forms enamine acetate ... hydrolyzed to ... estrone.

Isolated from pregnant human urine, synthesis from ergosterol.

Occurs in pregnancy urine on women and mares, in follicular liquor of many animals, in human placenta, in urine of bulls and stallions, in palm-kernel oil. Isoln: Butenandt, Naturwiss. 17, 879 (1929), Doisy et al., Am. J. Physiol. 90, 329 (1929).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Estrone is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Estrone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Estrone, based on the data on this page

What is Estrone?

Estrone is a 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17. It has a role as an antineoplastic agent, an estrogen, a bone density conservation agent, a mouse metabolite and a human metabolite.

What is the CAS number of Estrone?

The CAS registry number of Estrone is 53-16-7. Other or deprecated CAS numbers: 19973-76-3.

What is the molecular formula and weight of Estrone?

The molecular formula of Estrone is C18H22O2 and its molar mass is 270.37 g/mol.

What is Estrone used for?

Veterinary medication:. In the preparation of commercial 19-norsteriods. Use classes: Pharmaceuticals.

Is Estrone hazardous?

Estrone carries the GHS signal word "Danger". Main hazards: may cause cancer, suspected of causing cancer, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Estrone?

Estrone is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Estrone?

CompoundList lists 98 suppliers of Estrone in China, United States, Germany, United Kingdom and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Estrone in India?

2 suppliers in India list Estrone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Estrone?

Suppliers quote Estrone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Estrone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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