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Heterocyclic building blocks

6-Hydroxymelatonin

Also known as N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide, N-(2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide, Acetamide, N-(2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl)-

CAS 2208-41-5Formula C13H16N2O3Molar mass 248.28 g/molEC 636-648-1
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 5 suppliers listed
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6-Hydroxymelatonin chemical structure, C13H16N2O3, CAS 2208-41-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2208-41-5
Formula
C13H16N2O3
Molar mass
248.28 g/mol
EC number
636-648-1
HS code
293399
Category
Heterocyclic building blocks

What is 6-Hydroxymelatonin?

Plain description, key identifiers and synonyms

6-hydroxymelatonin is a member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6. It has a role as a metabolite and a mouse metabolite. It is a member of acetamides and a member of tryptamines. It is functionally related to a melatonin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
CAS number
2208-41-5 CAS number cross-checked
EC number
636-648-1
Molecular formula
C13H16N2O3
UNII
TV437T5077
MDL number
MFCD00037971
InChIKey
OMYMRCXOJJZYKE-UHFFFAOYSA-N
InChI
InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
SMILES (canonical and isomeric)
CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)O

Synonyms

  • N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
  • N-(2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide
  • Acetamide, N-(2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl)-
  • Acetamide, N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-
  • N-(2(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide
  • 6-hydroxy melatonin
  • melatonin, 6-Hydroxy
  • Acetamide, N-(2-(6-hydroxy-5-methoxyindol-3-yl)ethyl)-
  • 6-OH-melatonin
  • Acetamide, N-[2-(6-hydroxy-5-methoxyindol-3-yl)ethyl]-
  • Melatonin,6-Hydroxy
  • Melatonin, 6-hydroxy-
  • PDSP1_001787
  • PDSP1_001812
  • PDSP2_001770
  • PDSP2_001795
  • Sdccgsbi-0050594.p002
  • 5-22-12-00353 (Beilstein Handbook Reference)
  • N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide #
  • 6-Hydroxymelatonin, N-(2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
248.28 g/molcalc.
Exact mass
248.1161 Dacalc.
LogP (octanol/water)
1.56calc.
Topological polar surface area
74.35 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.31calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2[nH]ccc2c1

c1ccc2[nH]ccc2c1

2 rings, 9 atoms, the Indole ring system.

25,097 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H351Suspected of causing cancer.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

6-Hydroxymelatonin suppliers

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All 5 suppliers
5 of 5 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

5 suppliers in 3 countries

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6-Hydroxymelatonin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Cardiotonic Agents

Roles

  • animal metabolite
  • eukaryotic metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite

Pharmacology

6-Hydroxymelatonin is a naturally occurring, endogenous tryptamine that is the major active metabolite of the hormone melatonin. 6-hydroxymelatonin (6-OHM) binds to and activates melatonin receptors, which is involved in regulating sleep and wake cycles and the synthesis and secretion of other neurotransmitters such as dopamine and GABA.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 6-Hydroxymelatonin is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 6-Hydroxymelatonin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 6-Hydroxymelatonin, based on the data on this page

What is 6-Hydroxymelatonin?

6-hydroxymelatonin is a member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6. It has a role as a metabolite and a mouse metabolite. It is a member of acetamides and a member of tryptamines. It is functionally related to a melatonin.

What is the CAS number of 6-Hydroxymelatonin?

The CAS registry number of 6-Hydroxymelatonin is 2208-41-5.

What is the molecular formula and weight of 6-Hydroxymelatonin?

The molecular formula of 6-Hydroxymelatonin is C13H16N2O3 and its molar mass is 248.28 g/mol.

What is 6-Hydroxymelatonin used for?

Known uses and roles of 6-Hydroxymelatonin include building blocks in research and laboratory, screening compounds in research and laboratory, animal metabolite, eukaryotic metabolite, mammalian metabolite and 3 more.

Is 6-Hydroxymelatonin hazardous?

6-Hydroxymelatonin carries the GHS signal word "Warning". Main hazards: harmful if swallowed, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 6-Hydroxymelatonin?

6-Hydroxymelatonin is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 6-Hydroxymelatonin?

CompoundList lists 5 suppliers of 6-Hydroxymelatonin in China, United States and Czech Republic. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 6-Hydroxymelatonin?

Suppliers quote 6-Hydroxymelatonin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 6-Hydroxymelatonin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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