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Flavonoids and polyphenols

Acacetin

Also known as Linarigenin, 5,7-Dihydroxy-4'-methoxyflavone, 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one

CAS 480-44-4Formula C16H12O5Molar mass 284.27 g/molEC 207-552-3
GHS signal word: Warning. Pictograms: Harmful or irritant 57 suppliers listed
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Acacetin chemical structure, C16H12O5, CAS 480-44-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
480-44-4
Formula
C16H12O5
Molar mass
284.27 g/mol
EC number
207-552-3
HS code
293299
Category
Flavonoids and polyphenols

What is Acacetin?

Plain description, key identifiers and synonyms

5,7-dihydroxy-4'-methoxyflavone is a monomethoxyflavone that is the 4'-methyl ether derivative of apigenin. It has a role as an anticonvulsant and a plant metabolite. It is a monomethoxyflavone and a dihydroxyflavone. It is functionally related to an apigenin. It is a conjugate acid of a 5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
CAS number
480-44-4 CAS number cross-checked
EC number
207-552-3
Molecular formula
C16H12O5
UNII
KWI7J0A2CC
MDL number
MFCD00016936
InChIKey
DANYIYRPLHHOCZ-UHFFFAOYSA-N
InChI
InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3
SMILES (canonical and isomeric)
COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O

Synonyms

  • Linarigenin
  • 5,7-Dihydroxy-4'-methoxyflavone
  • 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
  • 4'-Methoxy-5,7-dihydroxyflavone
  • Buddleoflavonol
  • 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
  • Acacetine
  • 4'-Methoxyapigenin
  • Linarisenin
  • Akatsetin
  • Apigenin 4'-methyl ether
  • 5,7-Dioxy-4'-methoxyflavone
  • Apisenin 4'-methyl ether
  • Apigenin 4'-dimethyl ether
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)-
  • Acaetin
  • 4'-O-Methylapigenin
  • 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-one
  • Flavone, 5,7-dihydroxy-4'-methoxy-
  • Acacetin (Standard)
  • 5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone
  • 4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-methoxyphenyl)-
  • accacetin
  • Acaceztin
  • Acacetin?
Show all 33 synonyms
  • 4'-Methylapigenin
  • 4'-O-methyl apigenin
  • 4'-O-methyl-apigenin
  • Kinome_3212
  • 2-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • Acacetin, analytical standard
  • 5-18-04-00575 (Beilstein Handbook Reference)
  • DivK1c_000878

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
284.27 g/molcalc.
Exact mass
284.0685 Dacalc.
LogP (octanol/water)
2.88calc.
Topological polar surface area
79.9 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.06calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2ccccc12

O=c1cc(-c2ccccc2)oc2ccccc12

3 rings, 17 atoms, the Flavone ring system.

2,273 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Acacetin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 57 suppliers
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Where suppliers are based

57 suppliers in 8 countries

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Acacetin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anticonvulsant
  • central nervous system depressant
  • central nervous system drug
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Acacetin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Acacetin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Acacetin, based on the data on this page

What is Acacetin?

5,7-dihydroxy-4'-methoxyflavone is a monomethoxyflavone that is the 4'-methyl ether derivative of apigenin. It has a role as an anticonvulsant and a plant metabolite. It is a monomethoxyflavone and a dihydroxyflavone. It is functionally related to an apigenin.

What is the CAS number of Acacetin?

The CAS registry number of Acacetin is 480-44-4.

What is the molecular formula and weight of Acacetin?

The molecular formula of Acacetin is C16H12O5 and its molar mass is 284.27 g/mol.

What is Acacetin used for?

Known uses and roles of Acacetin include anticonvulsant, central nervous system depressant, central nervous system drug, eukaryotic metabolite, metabolite and 2 more.

Is Acacetin hazardous?

Acacetin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Acacetin?

Acacetin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Acacetin?

CompoundList lists 57 suppliers of Acacetin in China, United States, France, South Korea and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Acacetin?

Suppliers quote Acacetin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Acacetin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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