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Screening compounds

Adrixetinib

Also known as N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-propyl-4-(2,2,2-trifluoroethoxy)pyrazole-3-carboxamide, N-{5-[(6,7-Dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-propyl-4-(2,2,2-trifluoroethoxy)-1H-pyrazole-3-carboxamide, example 7

CAS 2394874-66-7Formula C25H24F3N5O5Molar mass 531.49 g/mol
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Adrixetinib chemical structure, C25H24F3N5O5, CAS 2394874-66-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2394874-66-7
Formula
C25H24F3N5O5
Molar mass
531.49 g/mol
HS code
293349
Category
Screening compounds

What is Adrixetinib?

Plain description, key identifiers and synonyms

Adrixetinib is an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO), Mer, and colony stimulating factor-1 receptor (CSF1R, CSF-1R, CD115, M-CSFR), with potential immunomodulatory, chemo-sensitizing and antineoplastic activities. Upon oral administration, adrixetinib targets, binds to and blocks the activity of Axl, Mer and CSF1R, thereby blocking Axl-, Mer- and CSF1R-mediated signaling pathways. This inhibits proliferation of Axl- and Mer-expressing tumor cells. In addition, blocking Axl- and Mer-mediated signaling may re-activate the innate immune system against cancer cells. Blocking CSF1R-mediated signaling inhibits the activities of tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and recruitment of myeloid-derived suppressor cells (MDSCs).

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Altogether, this abrogates immune suppression in the tumor microenvironment (TME), enhances antitumor T-cell immune responses and inhibits the proliferation of tumor cells. CSF1R, also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface receptor that plays major roles in tumor cell proliferation, metastasis, and cancer-associated immune suppression. Axl and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis, and the inactivation of innate immunity in cancer.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[5-(6,7-dimethoxyquinolin-4-yl)oxy-2-pyridinyl]-1-propyl-4-(2,2,2-trifluoroethoxy)pyrazole-3-carboxamide
CAS number
2394874-66-7
Molecular formula
C25H24F3N5O5
UNII
JIJ7I9XO8B
InChIKey
BWUUJXXFCSYLFW-UHFFFAOYSA-N
InChI
InChI=1S/C25H24F3N5O5/c1-4-9-33-13-21(37-14-25(26,27)28)23(32-33)24(34)31-22-6-5-15(12-30-22)38-18-7-8-29-17-11-20(36-3)19(35-2)10-16(17)18/h5-8,10-13H,4,9,14H2,1-3H3,(H,30,31,34)
SMILES (canonical and isomeric)
CCCN1C=C(C(=N1)C(=O)NC2=NC=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)OCC(F)(F)F

Synonyms

  • N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-propyl-4-(2,2,2-trifluoroethoxy)pyrazole-3-carboxamide
  • N-{5-[(6,7-Dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-propyl-4-(2,2,2-trifluoroethoxy)-1H-pyrazole-3-carboxamide
  • example 7
  • 1H-Pyrazole-3-carboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-propyl-4-(2,2,2-trifluoroethoxy)-
  • N-[5-(6,7-dimethoxyquinolin-4-yl)oxy-2-pyridinyl]-1-propyl-4-(2,2,2-trifluoroethoxy)pyrazole-3-carboxamide
  • N-[5-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1-propyl-4-(2,2,2-trifluoroethoxy)-1H-pyrazole-3-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
531.49 g/molcalc.
Exact mass
531.173 Dacalc.
LogP (octanol/water)
5.24calc.
Topological polar surface area
109.6 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
10calc.
Heavy atoms
38calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.28calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccc(Oc2ccnc3ccccc23)cn1)c1cc[nH]n1

O=C(Nc1ccc(Oc2ccnc3ccccc23)cn1)c1cc[nH]n1

4 rings, 25 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Adrixetinib suppliers

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Adrixetinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Adrixetinib is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Adrixetinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Adrixetinib, based on the data on this page

What is Adrixetinib?

Adrixetinib is an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO), Mer, and colony stimulating factor-1 receptor (CSF1R, CSF-1R, CD115, M-CSFR), with potential immunomodulatory, chemo-sensitizing and antineoplastic activities.

What is the CAS number of Adrixetinib?

The CAS registry number of Adrixetinib is 2394874-66-7.

What is the molecular formula and weight of Adrixetinib?

The molecular formula of Adrixetinib is C25H24F3N5O5 and its molar mass is 531.49 g/mol.

What is Adrixetinib used for?

Known uses and roles of Adrixetinib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Adrixetinib hazardous?

No GHS hazard classification for Adrixetinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Adrixetinib?

Adrixetinib is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Adrixetinib?

Post a free request on CompoundList and suppliers of Adrixetinib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Adrixetinib?

Suppliers quote Adrixetinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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