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Heterocyclic building blocks

Avadomide

Also known as cc-122, CC 122, Avadomida

CAS 1015474-32-4Formula C14H14N4O3Molar mass 286.29 g/molEC 876-404-3
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Avadomide chemical structure, C14H14N4O3, CAS 1015474-32-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1015474-32-4
Formula
C14H14N4O3
Molar mass
286.29 g/mol
EC number
876-404-3
HS code
293359
Category
Heterocyclic building blocks

What is Avadomide?

Plain description, key identifiers and synonyms

Avadomide is a novel, small molecule cereblon-modulating agent with potential antineoplastic, antiangiogenic and immunomodulatory activities. Upon oral administration, avadomide binds to and modulates cereblon to promote recruitment of the hematopoietic transcription factors Aiolos and Ikaros to the Cullin-4 RING E3 ubiquitin ligase complex. This binding results in the ubiquitination and rapid proteasomal degradation of Aiolos and Ikaros and the derepression of interferon (IFN)-stimulated genes, including DDX58 and IRF7, leading to apoptosis of certain tumor cells. Additionally, Aiolos degredation leads to derepression of the IL2 gene, thereby enhancing interleukin-2 production, costimulation of T-lymphocytes and IL-2-induced T-cell proliferation. Avadomide may also promote the activation of natural killer (NK) cells, potentially enhancing tumor cell killing. Aiolos and Ikaros are transcriptional repressors known to play an important role in normal B- and T-cell function.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
CAS number
1015474-32-4
EC number
876-404-3
Molecular formula
C14H14N4O3
UNII
28DZS29F59
MDL number
MFCD29919294
InChIKey
RSNPAKAFCAAMBH-UHFFFAOYSA-N
InChI
InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20)
SMILES (canonical and isomeric)
CC1=NC2=CC=CC(=C2C(=O)N1C3CCC(=O)NC3=O)N

Synonyms

  • cc-122
  • CC 122
  • Avadomida
  • 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
  • 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-
  • avadomidum
  • 3-(5-Amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione
  • CC-122Avadomide
  • Avadomide (CC-122)
  • 3-(5-Amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-2,6-piperidinedione
  • 3-(5-Amino-2-methyl-4-oxo-4H-quinazolin-3-yl)piperidine-2,6-dione
  • 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione
  • 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-, 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-
  • 3-[5-Amino-2-methyl-4-oxoquinazolin-3(4H)-yl]piperidine-2,6-dione
  • MAFEN
  • CC-122Avadomide?
  • Avadomide(CC-122)
  • Avadomide (USAN/INN)
  • US9694015, Compound A
  • 3-(5-amino-2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)piperidine-2,6-dione
  • Compound A
  • 3-(5-amino-2-methyl-4-oxo-quinazolin-3-yl)piperidine-2,6-dione
  • 3-(5-amino-2-methy-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione
  • 3-(5-amino-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione
  • rac-(3R)-3-(5-Amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
286.29 g/molcalc.
Exact mass
286.1066 Dacalc.
LogP (octanol/water)
0.26calc.
Topological polar surface area
107.1 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC(n2cnc3ccccc3c2=O)C(=O)N1

O=C1CCC(n2cnc3ccccc3c2=O)C(=O)N1

3 rings, 19 atoms, the 3-(4-Oxo-3,4-dihydroquinazolin-3-yl)-2,6-piperidinedione ring system.

54 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Avadomide suppliers

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All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Avadomide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Avadomide is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Avadomide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Avadomide, based on the data on this page

What is Avadomide?

Avadomide is a novel, small molecule cereblon-modulating agent with potential antineoplastic, antiangiogenic and immunomodulatory activities.

What is the CAS number of Avadomide?

The CAS registry number of Avadomide is 1015474-32-4.

What is the molecular formula and weight of Avadomide?

The molecular formula of Avadomide is C14H14N4O3 and its molar mass is 286.29 g/mol.

What is Avadomide used for?

Known uses and roles of Avadomide include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Avadomide hazardous?

No GHS hazard classification for Avadomide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Avadomide?

Avadomide is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Avadomide?

CompoundList lists 2 suppliers of Avadomide in Japan and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Avadomide?

Suppliers quote Avadomide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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