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Pharmaceuticals and APIs

Cevimeline hydrochloride

Also known as Cevimeline HCl, Saligren, cevimeline hydrochloride hydrate

CAS 153504-70-2Formula C20H38Cl2N2O3S2Molar mass 489.58 g/molEC 642-988-1
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 12 suppliers listed Drug substance
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Cevimeline hydrochloride chemical structure, C20H38Cl2N2O3S2, CAS 153504-70-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
153504-70-2
Formula
C20H38Cl2N2O3S2
Molar mass
489.58 g/mol
EC number
642-988-1
HS code
293499
Category
Pharmaceuticals and APIs

What is Cevimeline hydrochloride?

Plain description, key identifiers and synonyms

Cevimeline Hydrochloride is a cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the secretions in exocrine salivary and sweat glands. This cholinergic agonist also increases the tone of smooth muscle in the gastrointestinal and urinary tracts. Cevimeline is being studied as a treatment for dry mouth caused by radiation therapy to the head and neck.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
bis((2S,5S)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane]), hydrate, dihydrochloride
CAS number
153504-70-2Other or deprecated CAS: 1462862-74-3
EC number
642-988-1
Molecular formula
C20H38Cl2N2O3S2
UNII
P81Q6V85NP
InChIKey
ZSTLCHCDLIUXJE-ZGBAEQJLSA-N
InChI
InChI=1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m00.../s1
SMILES
C[C@H]1O[C@@]2(CN3CCC2CC3)CS1.C[C@H]1O[C@@]2(CN3CCC2CC3)CS1.O.Cl.Cl

Synonyms

  • Cevimeline HCl
  • Saligren
  • cevimeline hydrochloride hydrate
  • AF 102B
  • Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane), 2'-methyl-, hydrochloride, hydrate (2:1), cis-
  • Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, hydrochloride, hydrate (2:1), cis-
  • Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane), 2'-methyl-, hydrochloride, cis-
  • Cevimeline hydrochloride hemihydrate
  • Evoxac
  • (+)-Cevimeline hydrochloride hemihydrate
  • (+-)-cis-2-Methylspiro(1,3-oxathiolane-5,3'-quinuclidine) hydrochloride, hemihydrate
  • Cevimeline HCl hemihydrate
  • Cevimeline HCl 1/2H2O
  • cis-2-Methylspiro(1,3-oxathiolane-5,3')quinuclidine hydrochloride hydrate (2:2:1)
  • (+/-)-Cis-2-methylspiro(1,3-oxathiolane-5,3'-quinuclidine)hydrochloride, hemihydrate
  • (2S,5S)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane], hydrate, dihydrochloride
  • Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, hydrochloride, hydrate (2:2:1), (2'R,3R)-rel-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
489.58 g/molcalc.
Exact mass
488.1701 Dacalc.
LogP (octanol/water)
3.14calc.
Topological polar surface area
56.44 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
0calc.
Heavy atoms
29calc.
Rings
8calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
4calc.
Components
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1OC2(CS1)CN1CCC2CC1

C1OC2(CS1)CN1CCC2CC1

4 rings, 12 atoms.

20 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H332Harmful if inhaled.
  • H351Suspected of causing cancer.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (14)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cevimeline hydrochloride suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 12 suppliers
12 of 12 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

12 suppliers in 5 countries

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Cevimeline hydrochloride price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cevimeline hydrochloride is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Cevimeline hydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cevimeline hydrochloride, based on the data on this page

What is Cevimeline hydrochloride?

Cevimeline Hydrochloride is a cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the secretions in exocrine salivary and sweat glands.

What is the CAS number of Cevimeline hydrochloride?

The CAS registry number of Cevimeline hydrochloride is 153504-70-2. Other or deprecated CAS numbers: 1462862-74-3.

What is the molecular formula and weight of Cevimeline hydrochloride?

The molecular formula of Cevimeline hydrochloride is C20H38Cl2N2O3S2 and its molar mass is 489.58 g/mol.

Is Cevimeline hydrochloride hazardous?

Cevimeline hydrochloride carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if inhaled, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cevimeline hydrochloride?

Cevimeline hydrochloride is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cevimeline hydrochloride?

CompoundList lists 12 suppliers of Cevimeline hydrochloride in India, China, Germany, Japan and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cevimeline hydrochloride in India?

5 suppliers in India list Cevimeline hydrochloride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cevimeline hydrochloride?

Suppliers quote Cevimeline hydrochloride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cevimeline hydrochloride

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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