CompoundList
Sign in
Respiratory, allergy and digestive drugs

Domperidone

Also known as Motilium, Domperidona, Domperidonum

CAS 57808-66-9Formula C22H24ClN5O2Molar mass 425.92 g/molEC 260-968-7
GHS signal word: Warning. Pictograms: Serious health hazard 193 suppliers listed Drug substance
Get quotes Compare 193 suppliers
Domperidone chemical structure, C22H24ClN5O2, CAS 57808-66-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
57808-66-9
Formula
C22H24ClN5O2
Molar mass
425.92 g/mol
EC number
260-968-7
HS code
293339
Category
Respiratory, allergy and digestive drugs

What is Domperidone?

Plain description, key identifiers and synonyms

Domperidone is 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. It has a role as a dopaminergic antagonist and an antiemetic. It is a member of benzimidazoles and a heteroarylpiperidine.

Domperidone is a peripherally selective dopamine D2 receptor antagonist, used as an antiemetic, gastroprokinetic agent, and galactagogue.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
CAS number
57808-66-9 CAS number cross-checked
EC number
260-968-7
Molecular formula
C22H24ClN5O2
UNII
5587267Z69
MDL number
MFCD00069256
InChIKey
FGXWKSZFVQUSTL-UHFFFAOYSA-N
InChI
InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
SMILES (canonical and isomeric)
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O

Synonyms

  • Motilium
  • Domperidona
  • Domperidonum
  • KW 5338
  • 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
  • 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
  • 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone
  • Apo Domperidone
  • 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-
  • 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
  • Domperidon
  • Motilium 10
  • 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one
  • 2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-
  • 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
  • 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
  • 5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
  • Evoxin
  • Domilium
  • Equidone
  • Vivadone
  • Nu Domperidone
  • Equidone Gel
  • Novo Domperidone
  • PMS Domperidone
Show all 38 synonyms
  • Motilium instants
  • ratio Domperidone
  • Domperidon TEVA
  • Hexal, Domperidon
  • Stada, Domperidon
  • Gamir, Domperidona
  • 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo(d)imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo(d)imidazol-2(3H)-one
  • 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl)piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
  • 5-Chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one
  • 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl)-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
  • 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo(d)imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo(d)imidazol-2(3H)-one
  • 6-chloro-3-(1-(3-(2-oxo-3H-benzimidazol-1-yl)propyl)piperidin-4-yl)-1H-benzimidazol-2-one
  • Maleate, Domperidone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
425.92 g/molcalc.
Exact mass
425.1619 Dacalc.
LogP (octanol/water)
3.35calc.
Topological polar surface area
78.82 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
5calc.
Heavy atoms
30calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1

O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1

5 rings, 29 atoms, the 2H-Benzimidazol-2-one, 1,3-dihydro-1-(3-(4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)propyl)- ring system.

11 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Domperidone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 193 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

193 suppliers in 29 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Domperidone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Industries and functions

Pharmacological actions

  • Antiemetics
  • Dopamine Antagonists

Roles

  • antagonist
  • antidiarrhoeal drug
  • antidyskinesia agent
  • antiemetic
  • antiparkinson drug
  • dopaminergic agent
  • dopaminergic antagonist
  • gastrointestinal drug
  • immunomodulator
  • immunosuppressive agent
  • neurotransmitter agent
  • pharmaceutical

Pharmacology

Domperidone is a peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons, this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Domperidone is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Domperidone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Domperidone, based on the data on this page

What is Domperidone?

Domperidone is 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group.

What is the CAS number of Domperidone?

The CAS registry number of Domperidone is 57808-66-9.

What is the molecular formula and weight of Domperidone?

The molecular formula of Domperidone is C22H24ClN5O2 and its molar mass is 425.92 g/mol.

What is Domperidone used for?

Use classes: Animal Drugs.

Is Domperidone hazardous?

Domperidone carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Domperidone?

Domperidone is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Domperidone?

CompoundList lists 193 suppliers of Domperidone in India, United States, China, Bangladesh and 25 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Domperidone in India?

62 suppliers in India list Domperidone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Domperidone?

Suppliers quote Domperidone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Domperidone

Get quotes for Domperidone

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Domperidone
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Domperidone with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/domperidone-57808-66-9" title="Domperidone structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Respiratory, allergy and digestive drugs or HS code 293339

193 suppliers
Free quotes, contact stays private
Get quotes