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Heterocyclic building blocks

Gramine

Also known as 3-(Dimethylaminomethyl)indole, Donaxine, Donaxin

CAS 87-52-5Formula C11H14N2Molar mass 174.25 g/molEC 201-749-8
GHS signal word: Danger. Pictograms: Corrosive 31 suppliers listed
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Gramine chemical structure, C11H14N2, CAS 87-52-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
87-52-5
Formula
C11H14N2
Molar mass
174.25 g/mol
EC number
201-749-8
HS code
293399
Category
Heterocyclic building blocks

What is Gramine?

Plain description, key identifiers and synonyms

Gramine is an aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3. It has a role as an antiviral agent, an antibacterial agent, a serotonergic antagonist and a plant metabolite. It is an aminoalkylindole, an indole alkaloid and a tertiary amino compound. It is a conjugate base of a gramine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(1H-indol-3-yl)-N,N-dimethylmethanamine
CAS number
87-52-5 CAS number cross-checked
EC number
201-749-8
Molecular formula
C11H14N2
UNII
FGQ8A78L14
MDL number
MFCD00005629
InChIKey
OCDGBSUVYYVKQZ-UHFFFAOYSA-N
InChI
InChI=1S/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3
SMILES (canonical and isomeric)
CN(C)CC1=CNC2=CC=CC=C21

Synonyms

  • 3-(Dimethylaminomethyl)indole
  • Donaxine
  • Donaxin
  • Gramin
  • 1-(1H-indol-3-yl)-N,N-dimethylmethanamine
  • 1H-Indole-3-methanamine, N,N-dimethyl-
  • beta-Dimethylaminomethylindole
  • N,N-Dimethyl-1H-indole-3-methanamine
  • 3-(N,N-Dimethylaminomethyl)indole
  • (1H-indol-3-ylmethyl)dimethylamine
  • 3-[(Dimethylamino)methyl]indole
  • N,N-Dimethyl-1H-indole-3-methylamine
  • 3-((Dimethylamino)methyl)indole
  • 3-[Dimethylaminomethyl]indole
  • Indol-3-ylmethyldimethylamine
  • (1H-Indol-3-ylmethyl)-dimethyl-amine
  • (Indol-3-ylmethyl)dimethylamine
  • 1-(1H-indol-3-yl)-N,N-dimethyl-methanamine
  • Indole, 3-[(dimethylamino)methyl]-
  • [(1H-indol-3-yl)methyl]dimethylamine
  • Indole, 3-((dimethylamino)methyl)-
  • 3-((Dimethylamino)methyl)-Indole
  • 3-[(Dimethylamino)methyl]-Indole
  • Gramine (Standard)
  • Gramine, 99%
Show all 31 synonyms
  • b-(Dimethylaminomethyl)indole
  • beta -dimethylaminomethylindole
  • indole, 3-dimethylaminomethyl-
  • beta-(Dimethylaminomethyl)indole
  • 3-Dimethylaminomethylindol (gramin)
  • (1H-Indol-3-ylmethyl)-dimethylamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
174.25 g/molcalc.
Exact mass
174.1157 Dacalc.
LogP (octanol/water)
2.23calc.
Topological polar surface area
19.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
13calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.27calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2[nH]ccc2c1

c1ccc2[nH]ccc2c1

2 rings, 9 atoms, the Indole ring system.

25,097 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive

Hazard statements

  • H314Causes severe skin burns and eye damage.
  • H318Causes serious eye damage.
Precautionary statements (14)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
  • P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P363Wash contaminated clothing before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Gramine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 31 suppliers
30 of 30 offers

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Where suppliers are based

31 suppliers in 7 countries

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Gramine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antibacterial agent
  • antimicrobial agent
  • antiviral agent
  • eukaryotic metabolite
  • metabolite
  • neurotransmitter agent
  • pharmaceutical
  • plant metabolite
  • serotonergic antagonist
  • serotonergic drug

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Gramine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Gramine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Gramine, based on the data on this page

What is Gramine?

Gramine is an aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3. It has a role as an antiviral agent, an antibacterial agent, a serotonergic antagonist and a plant metabolite. It is an aminoalkylindole, an indole alkaloid and a tertiary amino compound.

What is the CAS number of Gramine?

The CAS registry number of Gramine is 87-52-5.

What is the molecular formula and weight of Gramine?

The molecular formula of Gramine is C11H14N2 and its molar mass is 174.25 g/mol.

What is Gramine used for?

Known uses and roles of Gramine include building blocks in research and laboratory, screening compounds in research and laboratory, antibacterial agent, antimicrobial agent, antiviral agent and 7 more.

Is Gramine hazardous?

Gramine carries the GHS signal word "Danger". Main hazards: causes severe skin burns and eye damage, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Gramine?

Gramine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Gramine?

CompoundList lists 31 suppliers of Gramine in China, United States, Germany, United Kingdom and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Gramine?

Suppliers quote Gramine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Gramine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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