Gs-441524 (CAS 1191237-69-0): price, suppliers and safety

What is Gs-441524?

Plain description, key identifiers and synonyms

GS-441524 is a C-nucleoside analog that is (2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile substituted by a 4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl group at position 2. It is the active metabolite of remdesivir and exhibits a broad range of inhibitory activity against various RNA viruses including HCV, parainfluenza and SARS-CoV. It has a role as an anticoronaviral agent, an antiviral agent and a drug metabolite. It is a nitrile, an aromatic amine, a C-nucleoside and a pyrrolotriazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
CAS number: 1191237-69-0 CAS number cross-checked
EC number: 857-885-9
Molecular formula: C₁₂H₁₃N₅O₄
UNII: 1BQK176DT6
MDL number: MFCD32666994
InChIKey: BRDWIEOJOWJCLU-LTGWCKQJSA-N
InChI: InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
Canonical SMILES: N#CC1(c2ccc3c(N)ncnn23)OC(CO)C(O)C1O
Isomeric SMILES: C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N

Synonyms

GS 441524
2-C-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile
2-c-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-d-altrononitrile
D-Altrononitrile, 2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-
13C3 GS-441524
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
Remdesivir Impurity 5
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
EVO 984
(2R,3R,4S,5R)-2-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
(2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile
reacted form
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
Nucleoside of Remdesivir
Remdesivir metabolite(GS-441524)
Remdesivir metabolite(GS-441524)?
Remdesivir intermediate(GS-441524)
Remdesivir intermediate?GS-441524?
(2R,3R,4S,5R)-2-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furancarbonitrile
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(h
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furancarbonitrile
(2r,3r,4s,5r)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazine-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
(2R3R4S5R)-2-(4-aminopyrrolo[21-f][124]triazin-7-yl)-34-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	291.27 g/molcalc.
Exact mass	291.0968 Dacalc.
LogP (octanol/water)	-1.86calc.
Topological polar surface area	149.9 Å²calc.
Hydrogen bond donors	4calc.
Hydrogen bond acceptors	8calc.
Rotatable bonds	2calc.
Heavy atoms	21calc.
Rings	3calc.
Aromatic rings	2calc.
Fraction sp3 carbons	0.42calc.
Formal charge	0calc.
Stereocentres	4calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

c1ncc2ccc(C3CCCO3)n2n1

3 rings, 14 atoms.

31 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Danger

Corrosive

Harmful or irritant

Serious health hazard

Hazard statements

H315Causes skin irritation.
H317May cause an allergic skin reaction.
H318Causes serious eye damage.
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335May cause respiratory irritation.
H341Suspected of causing genetic defects.
H361Suspected of damaging fertility or the unborn child.
H371May cause damage to organs.

Precautionary statements (27)

P203Obtain, read and follow all safety instructions before use.
P233Keep container tightly closed.
P260Do not breathe dust, fume, gas, mist, vapours or spray.
P261Avoid breathing dust, fume, gas, mist, vapours or spray.
P264Wash skin thoroughly after handling.
P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves, protective clothing, eye protection and face protection.
P284In case of inadequate ventilation wear respiratory protection.
P302 + P352If on skin: Wash with plenty of water.
P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P316If exposed or concerned: Get emergency medical help immediately.
P317Get medical help.
P318If exposed or concerned, get medical advice.
P319Get medical help if you feel unwell.
P321Specific treatment (see supplemental first aid instructions on the label).
P332 + P317If skin irritation occurs: Get medical help.
P333 + P317If skin irritation or rash occurs: Get medical help.
P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
P362 + P364Take off contaminated clothing. And wash it before reuse.
P403Store in a well-ventilated place.
P403 + P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Gs-441524 suppliers

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All 24 suppliers

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Twochem
ChinaUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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Jiangsu Zenji Pharmaceuticals Ltd.
China, Huaian ManufacturerUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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Taizhou Volsen Chemical Co., Ltd
China ManufacturerUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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Abmole Bioscience Inc.
United States, HoustonUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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AChemBlock
United States, HaywardUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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ACTIVATE SCIENTIFIC GmbH
GermanyUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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Angel Pharmatech Ltd.
China, ShanghaiUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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AvaChem Scientific LLC
United StatesUnclaimed profile
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BioChemPartner
China, ShangHaiUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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Biosynce Pharmatech
China, ChengduUnclaimed profile
Gs-441524Grade, purity and minimum order on request
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Where suppliers are based

24 suppliers in 4 countries

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Gs-441524 price

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Antivirals in pharmaceuticals

Pharmacological actions

Antiviral Agents

Roles

animal metabolite
anticoronaviral agent
antimicrobial agent
antiviral agent
drug metabolite
eukaryotic metabolite
human metabolite
human xenobiotic metabolite
mammalian metabolite
metabolite
xenobiotic metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Gs-441524 is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024

$26.7B

+15.0% vs 2023, imports $26.3B

2019 to 2024

Top exporters

Ireland26.3%
China15.7%
Singapore10.3%

Top importers

Reported customs values in USD, not prices.Full trade data

The HS code shown for Gs-441524 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

7QK7Uhp3TK chemical structure, C12H14ClN5O4, CAS 2378280-82-9

7QK7Uhp3TK2378280-82-9C₁₂H₁₄ClN₅O₄

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

(2S,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile chemical structure, C12H13N5O4, CAS 1355049-95-4

(2S,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile1355049-95-4C₁₂H₁₃N₅O₄

(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile chemical structure, C12H13N5O4, CAS 2324118-50-3

(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile2324118-50-3C₁₂H₁₃N₅O₄

Deuremidevir des-triisobutryl chemical structure, C12H13N5O4, CAS 2647440-98-8

Deuremidevir des-triisobutryl2647440-98-8C₁₂H₁₃N₅O₄

2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl-2,5,6-d3)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile chemical structure, C12H13N5O4, CAS 2460489-86-3

2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl-2,5,6-d3)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile2460489-86-3C₁₂H₁₃N₅O₄

2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl-d2)tetrahydrofuran-2-carbonitrile-3,4-d2 chemical structure, C12H13N5O4, CAS 2460489-83-0

2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl-d2)tetrahydrofuran-2-carbonitrile-3,4-d22460489-83-0C₁₂H₁₃N₅O₄

2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl-2,5,6-d3)-3,4-dihydroxy-5-(hydroxymethyl-d2)tetrahydrofuran-2-carbonitrile-3,4-d2 chemical structure, C12H13N5O4, CAS 2460489-85-2

2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl-2,5,6-d3)-3,4-dihydroxy-5-(hydroxymethyl-d2)tetrahydrofuran-2-carbonitrile-3,4-d22460489-85-2C₁₂H₁₃N₅O₄

(2S,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile chemical structure, C12H13N5O4, CAS 2324118-49-0

(2S,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile2324118-49-0C₁₂H₁₃N₅O₄

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

GS-441524 monophosphate chemical structure, C12H14N5O7P, CAS 1911578-74-9

(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile chemical structure, C15H17N5O4, CAS 1191237-80-5

GS-441524 diphosphate, Remdesivir metabolite chemical structure, C12H15N5O10P2

GS-441524 triphosphate chemical structure, C12H16N5O13P3, CAS 1355149-45-9

GS-441524 sodium chemical structure, C12H12N5Na4O13P3, CAS 1355050-21-3

Ddh Remdesivir Nuc, ddh GS 441524 chemical structure, C12H11N5O3, CAS 2761973-74-2

Same formula isomers

Different compounds that share this molecular formula

All isomers

Toyocamycin chemical structure, C12H13N5O4, CAS 606-58-6

Toyocamycin606-58-6C₁₂H₁₃N₅O₄3 suppliers

1,N(6)-Ethenoadenosine chemical structure, C12H13N5O4, CAS 39007-51-7

1,N(6)-Ethenoadenosine39007-51-7C₁₂H₁₃N₅O₄2 suppliers

Carprazidil chemical structure, C12H13N5O4, CAS 68020-77-9

Carprazidil68020-77-9C₁₂H₁₃N₅O₄1 supplier

1,N(2)-Ethenodeoxyguanosine chemical structure, C12H13N5O4, CAS 108929-11-9

1,N(2)-Ethenodeoxyguanosine108929-11-9C₁₂H₁₃N₅O₄

9-(2-Deoxy-4-C-ethynyl-beta-D-ribo-pentofuranosyl)guanine chemical structure, C12H13N5O4, CAS 306305-14-6

9-(2-Deoxy-4-C-ethynyl-beta-D-ribo-pentofuranosyl)guanine306305-14-6C₁₂H₁₃N₅O₄1 supplier

4-Amino-7-beta-D-arabinofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carbonitrile chemical structure, C12H13N5O4, CAS 90813-71-1

4-Amino-7-beta-D-arabinofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carbonitrile90813-71-1C₁₂H₁₃N₅O₄1 supplier

7H-Pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine, 7-beta-D-ribofuranosyl- chemical structure, C12H13N5O4, CAS 78582-20-4

7H-Pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine, 7-beta-D-ribofuranosyl-78582-20-4C₁₂H₁₃N₅O₄

(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3-ethynyl-2-(hydroxymethyl)oxolane-3,4-diol chemical structure, C12H13N5O4, CAS 180300-54-3

(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3-ethynyl-2-(hydroxymethyl)oxolane-3,4-diol180300-54-3C₁₂H₁₃N₅O₄1 supplier

N(2),3-Ethenodeoxyguanosine chemical structure, C12H13N5O4, CAS 121055-53-6

N(2),3-Ethenodeoxyguanosine121055-53-6C₁₂H₁₃N₅O₄

2-[4-(4-Methoxyphenyl)-5-nitroimidazol-1-yl]acetohydrazide chemical structure, C12H13N5O4, CAS 66222-81-9

2-[4-(4-Methoxyphenyl)-5-nitroimidazol-1-yl]acetohydrazide66222-81-9C₁₂H₁₃N₅O₄

N4-(3,4-dimethoxyphenyl)-5-nitropyrimidine-4,6-diamine chemical structure, C12H13N5O4, CAS 450345-44-5

N4-(3,4-dimethoxyphenyl)-5-nitropyrimidine-4,6-diamine450345-44-5C₁₂H₁₃N₅O₄

2'-C-Ethynyladenosine chemical structure, C12H13N5O4, CAS 640725-76-4

2'-C-Ethynyladenosine640725-76-4C₁₂H₁₃N₅O₄1 supplier

Frequently asked questions

Quick answers about Gs-441524, based on the data on this page

What is Gs-441524?

GS-441524 is a C-nucleoside analog that is (2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile substituted by a 4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl group at position 2.

What is the CAS number of Gs-441524?

The CAS registry number of Gs-441524 is 1191237-69-0.

What is the molecular formula and weight of Gs-441524?

The molecular formula of Gs-441524 is C12H13N5O4 and its molar mass is 291.27 g/mol.

What is Gs-441524 used for?

Known uses and roles of Gs-441524 include antivirals in pharmaceuticals, animal metabolite, anticoronaviral agent, antimicrobial agent, antiviral agent and 8 more.

Is Gs-441524 hazardous?

Gs-441524 carries the GHS signal word "Danger". Main hazards: causes skin irritation, may cause an allergic skin reaction, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Gs-441524?

Gs-441524 is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Gs-441524?

CompoundList lists 24 suppliers of Gs-441524 in China, United States, Czech Republic and Germany. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Gs-441524?

Suppliers quote Gs-441524 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Gs-441524

Key facts

What is Gs-441524?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Gs-441524 suppliers

Where suppliers are based

Send one request to many suppliers

Gs-441524 price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Regulatory status

Health and food

HS code and trade data

Global trade

Frequently asked questions

What is Gs-441524?

What is the CAS number of Gs-441524?

What is the molecular formula and weight of Gs-441524?

What is Gs-441524 used for?

Is Gs-441524 hazardous?

What is the HS code of Gs-441524?

Where can I buy Gs-441524?

What is the price of Gs-441524?

Guides for buyers

Get quotes for Gs-441524

Key facts

What is Gs-441524?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Gs-441524 suppliers

Where suppliers are based

Send one request to many suppliers

Gs-441524 price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Regulatory status

Health and food

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Frequently asked questions

What is Gs-441524?

What is the CAS number of Gs-441524?

What is the molecular formula and weight of Gs-441524?

What is Gs-441524 used for?

Is Gs-441524 hazardous?

What is the HS code of Gs-441524?

Where can I buy Gs-441524?

What is the price of Gs-441524?

Guides for buyers

Get quotes for Gs-441524