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Alkaloids

Guvacoline

Also known as Guvacine methyl ester, methyl 1,2,3,6-tetrahydropyridine-5-carboxylate, Methyl 1,2,5,6-tetrahydro-3-pyridinecarboxylate

CAS 495-19-2Formula C7H11NO2Molar mass 141.17 g/mol
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Guvacoline chemical structure, C7H11NO2, CAS 495-19-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
495-19-2
Formula
C7H11NO2
Molar mass
141.17 g/mol
HS code
293979
Category
Alkaloids

What is Guvacoline?

Plain description, key identifiers and synonyms

Guvacoline is the methyl ester of guvacine. It has a role as a muscarinic agonist and a plant metabolite. It is a methyl ester, a pyridine alkaloid, a tetrahydropyridine, a secondary amino compound, an enoate ester, an alpha,beta-unsaturated carboxylic ester and a beta-amino acid ester. It is functionally related to a guvacine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl 1,2,3,6-tetrahydropyridine-5-carboxylate
CAS number
495-19-2 CAS number cross-checked
Molecular formula
C7H11NO2
UNII
YT3OF85P98
MDL number
MFCD02683335
InChIKey
DYPLDWLIOGXSSE-UHFFFAOYSA-N
InChI
InChI=1S/C7H11NO2/c1-10-7(9)6-3-2-4-8-5-6/h3,8H,2,4-5H2,1H3
SMILES (canonical and isomeric)
COC(=O)C1=CCCNC1

Synonyms

  • Guvacine methyl ester
  • methyl 1,2,3,6-tetrahydropyridine-5-carboxylate
  • Methyl 1,2,5,6-tetrahydro-3-pyridinecarboxylate
  • Methyl 1,2,5,6-tetrahydronicotinate
  • 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, methyl ester
  • methyl 1,2,5,6-tetrahydropyridine-3-carboxylate
  • 3-(Methoxycarbonyl)-1,2,5,6-tetrahydropyridine
  • Guvacine free base
  • guavacoline
  • 498-96-4 (free base)
  • Nicotinic acid, 1,2,5,6-tetrahydro-, methyl ester
  • 1,2,5,6-Tetrahydro-pyridine-3-carboxylic acid methyl ester

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
141.17 g/molcalc.
Exact mass
141.079 Dacalc.
LogP (octanol/water)
0.08calc.
Topological polar surface area
38.33 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
10calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.57calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CCNCC1

C1=CCNCC1

1 ring, 6 atoms, the 1,2,3,6-Tetrahydropyridine ring system.

987 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Guvacoline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

No supplier listings yet

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Guvacoline price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • cholinergic agonist
  • cholinergic drug
  • eukaryotic metabolite
  • metabolite
  • muscarinic agonist
  • neurotransmitter agent
  • pharmaceutical
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Guvacoline is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Guvacoline is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Guvacoline, based on the data on this page

What is Guvacoline?

Guvacoline is the methyl ester of guvacine. It has a role as a muscarinic agonist and a plant metabolite. It is a methyl ester, a pyridine alkaloid, a tetrahydropyridine, a secondary amino compound, an enoate ester, an alpha,beta-unsaturated carboxylic ester and a beta-amino acid ester.

What is the CAS number of Guvacoline?

The CAS registry number of Guvacoline is 495-19-2.

What is the molecular formula and weight of Guvacoline?

The molecular formula of Guvacoline is C7H11NO2 and its molar mass is 141.17 g/mol.

What is Guvacoline used for?

Known uses and roles of Guvacoline include cholinergic agonist, cholinergic drug, eukaryotic metabolite, metabolite, muscarinic agonist and 3 more.

Is Guvacoline hazardous?

No GHS hazard classification for Guvacoline is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Guvacoline?

Guvacoline is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Guvacoline?

Post a free request on CompoundList and suppliers of Guvacoline will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Guvacoline?

Suppliers quote Guvacoline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Guvacoline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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