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Herbicides

Herbimycin A

Also known as Herbimycin, Antibiotic Tan 420F, Geldanamycin, 17-demethoxy-15-methoxy-11-O-methyl-, (15R)-

CAS 70563-58-5Formula C30H42N2O9Molar mass 574.67 g/mol
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Herbimycin A chemical structure, C30H42N2O9, CAS 70563-58-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
70563-58-5
Formula
C30H42N2O9
Molar mass
574.67 g/mol
HS code
293379
Category
Herbicides

What is Herbimycin A?

Plain description, key identifiers and synonyms

Herbimycin is a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects. It has a role as a herbicide, an antimicrobial agent, a tyrosine kinase inhibitor, a Hsp90 inhibitor and an apoptosis inducer. It is a member of 1,4-benzoquinones, a lactam and a macrocycle.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
CAS number
70563-58-5 CAS number cross-checked
Molecular formula
C30H42N2O9
UNII
815WDV2HST
MDL number
MFCD00151702
InChIKey
MCAHMSDENAOJFZ-BVXDHVRPSA-N
InChI
InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
Canonical SMILES
COC1C=CC=C(C)C(=O)NC2=CC(=O)C=C(C2=O)C(OC)C(C)CC(OC)C(OC)C(C)C=C(C)C1OC(N)=O
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)\C)C)OC)OC

Synonyms

  • Herbimycin
  • Antibiotic Tan 420F
  • Geldanamycin, 17-demethoxy-15-methoxy-11-O-methyl-, (15R)-
  • 17-Demethoxy-15-methoxy-11-O-methylgeldanamycin, (15R)-
  • (9S,12S,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo(16.3.1)docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
  • Herbimycin A from Streptomyces hygroscopicus
  • Herbimycin A, 95%
  • MEGxm0_000417
  • ACon0_000819
  • Herbimycin A from Streptomyces hygroscopicus, >=98.0% (HPLC)
  • Herbimycin A from Streptomyces hygroscopicus, >=95% (HPLC), powder

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
574.67 g/molcalc.
Exact mass
574.289 Dacalc.
LogP (octanol/water)
2.71calc.
Topological polar surface area
152.5 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
5calc.
Heavy atoms
41calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.53calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCCCCCC=CCCC=CC=CC(=O)NC(=C1)C2=O

O=C1C=C2CCCCCCC=CCCC=CC=CC(=O)NC(=C1)C2=O

2 rings, 25 atoms.

58 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Herbimycin A suppliers

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All 4 suppliers
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Where suppliers are based

4 suppliers in 2 countries

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Herbimycin A price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Enzyme Inhibitors

Roles

  • Hsp90 inhibitor
  • antimicrobial agent
  • apoptosis inducer
  • enzyme inhibitor
  • herbicide
  • pesticide
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Herbimycin is a benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Herbimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins, the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Herbimycin A is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Herbimycin A is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Herbimycin A, based on the data on this page

What is Herbimycin A?

Herbimycin is a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects. It has a role as a herbicide, an antimicrobial agent, a tyrosine kinase inhibitor, a Hsp90 inhibitor and an apoptosis inducer.

Guides for buyers

Practical guides that help when you source, ship or handle Herbimycin A

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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