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Screening compounds

Inixaciclib

Also known as 2-Pyrimidinamine, 5-fluoro-4-(8-fluoro-3,4-dihydro-4-(1-methylethyl)-2H-1,4-benzoxazin-6-yl)-N-(5-(1-methyl-4-piperidinyl)-2-pyridinyl)-, 5-Fluoro-4-(8-fluoro-4-(propan-2-yl)-3,4-dihydro-2H-1,4- benzoxazin-6-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2- yl)pyrimidin-2-amine, 5-Fluoro-4-[8-fluoro-3,4-dihydro-4-(1-methylethyl)-2H-1,4-benzoxazin-6-yl]-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-2-pyrimidinamine

CAS 2370913-42-9Formula C26H30F2N6OMolar mass 480.56 g/mol
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Inixaciclib chemical structure, C26H30F2N6O, CAS 2370913-42-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2370913-42-9
Formula
C26H30F2N6O
Molar mass
480.56 g/mol
HS code
293499
Category
Screening compounds

What is Inixaciclib?

Plain description, key identifiers and synonyms

Inixaciclib is an orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 2 (CDK2), 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, inixaciclib selectively targets and inhibits CDK2, CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase and prevents CDK-mediated G1-S-phase transition. This leads to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. CDKs are serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation and are upregulated in many tumor cell types. NUV-422 may be able to penetrate through the blood-brain barrier (BBB).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-fluoro-4-(8-fluoro-4-propan-2-yl-2,3-dihydro-1,4-benzoxazin-6-yl)-N-[5-(1-methylpiperidin-4-yl)-2-pyridinyl]pyrimidin-2-amine
CAS number
2370913-42-9
Molecular formula
C26H30F2N6O
UNII
Q6460P4C0B
InChIKey
YZSCPLGKKMSBMV-UHFFFAOYSA-N
InChI
InChI=1S/C26H30F2N6O/c1-16(2)34-10-11-35-25-20(27)12-19(13-22(25)34)24-21(28)15-30-26(32-24)31-23-5-4-18(14-29-23)17-6-8-33(3)9-7-17/h4-5,12-17H,6-11H2,1-3H3,(H,29,30,31,32)
SMILES (canonical and isomeric)
CC(C)N1CCOC2=C1C=C(C=C2F)C3=NC(=NC=C3F)NC4=NC=C(C=C4)C5CCN(CC5)C

Synonyms

  • 2-Pyrimidinamine, 5-fluoro-4-(8-fluoro-3,4-dihydro-4-(1-methylethyl)-2H-1,4-benzoxazin-6-yl)-N-(5-(1-methyl-4-piperidinyl)-2-pyridinyl)-
  • 5-Fluoro-4-(8-fluoro-4-(propan-2-yl)-3,4-dihydro-2H-1,4- benzoxazin-6-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2- yl)pyrimidin-2-amine
  • 5-Fluoro-4-[8-fluoro-3,4-dihydro-4-(1-methylethyl)-2H-1,4-benzoxazin-6-yl]-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-2-pyrimidinamine
  • 2-Pyrimidinamine, 5-fluoro-4-[8-fluoro-3,4-dihydro-4-(1-methylethyl)-2H-1,4-benzoxazin-6-yl]-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-
  • 5-fluoro-4-[8-fluoro-4-(propan-2-yl)-3,4-dihydro-2H-1,4- benzoxazin-6-yl]-N-[5-(1-methylpiperidin-4-yl)pyridin-2- yl]pyrimidin-2-amine
  • InixaciclibNUV-422
  • US11174252, Compound 442
  • 5-fluoro-4-(8-fluoro-4-propan-2-yl-2,3-dihydro-1,4-benzoxazin-6-yl)-N-[5-(1-methylpiperidin-4-yl)pyridin-2-yl]pyrimidin-2-amine
  • example 50
  • compound 442
  • 5-fluoro-4-(8-fluoro-4-isopropyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidin-2-amine
  • 5-fluoro-4-(8-fluoro-4-propan-2-yl-2,3-dihydro-1,4-benzoxazin-6-yl)-N-[5-(1-methylpiperidin-4-yl)-2-pyridinyl]pyrimidin-2-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
480.56 g/molcalc.
Exact mass
480.2449 Dacalc.
LogP (octanol/water)
4.98calc.
Topological polar surface area
66.41 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
5calc.
Heavy atoms
35calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(-c2ccc3c(c2)NCCO3)nc(Nc2ccc(C3CCNCC3)cn2)n1

c1cc(-c2ccc3c(c2)NCCO3)nc(Nc2ccc(C3CCNCC3)cn2)n1

5 rings, 29 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Inixaciclib suppliers

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All 2 suppliers

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Where suppliers are based

2 suppliers in 1 country

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Inixaciclib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Inixaciclib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Inixaciclib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Inixaciclib, based on the data on this page

What is Inixaciclib?

Inixaciclib is an orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 2 (CDK2), 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity.

What is the CAS number of Inixaciclib?

The CAS registry number of Inixaciclib is 2370913-42-9.

What is the molecular formula and weight of Inixaciclib?

The molecular formula of Inixaciclib is C26H30F2N6O and its molar mass is 480.56 g/mol.

What is Inixaciclib used for?

Known uses and roles of Inixaciclib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Inixaciclib hazardous?

No GHS hazard classification for Inixaciclib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Inixaciclib?

Inixaciclib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Inixaciclib?

CompoundList lists 2 suppliers of Inixaciclib in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Inixaciclib?

Suppliers quote Inixaciclib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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