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Aromatic building blocks

Levonordefrin

Also known as Corbadrine, Neo-Cobefrin, Corbadrina

CAS 829-74-3Formula C9H13NO3Molar mass 183.21 g/molEC 617-417-4
GHS signal word: Warning. Pictograms: Harmful or irritant 6 suppliers listed
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Levonordefrin chemical structure, C9H13NO3, CAS 829-74-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
829-74-3
Formula
C9H13NO3
Molar mass
183.21 g/mol
EC number
617-417-4
HS code
292250
Category
Aromatic building blocks

What is Levonordefrin?

Plain description, key identifiers and synonyms

Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol
CAS number
829-74-3 CAS number cross-checkedOther or deprecated CAS: 74812-63-8
EC number
617-417-4
Molecular formula
C9H13NO3
UNII
R81X549E70, V008L6478D
InChIKey
GEFQWZLICWMTKF-CDUCUWFYSA-N
InChI
InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
Canonical SMILES
CC(N)C(O)c1ccc(O)c(O)c1
Isomeric SMILES
C[C@@H]([C@@H](C1=CC(=C(C=C1)O)O)O)N

Synonyms

  • Corbadrine
  • Neo-Cobefrin
  • Corbadrina
  • alpha-Methylnoradrenaline
  • Corbadrinum
  • L-Nordefrin
  • 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol
  • (-)-cobefrin
  • Nordefrin, l-
  • BA 2818
  • L-alpha-Methylnoradrenaline
  • Isoadrenaline
  • Levonordefrin (USP)
  • L-norephedrine, 3,4-dihydroxy-
  • (-)-alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol
  • alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol
  • 4-((1R,2S)-2-amino-1-hydroxypropyl)benzene-1,2-diol
  • levoepinefrina
  • NeoCobefrin
  • Neo Cobefrin
  • Nordefrin (-)-
  • 1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)-,(R-(R*,S*))-
  • 4-(2-amino-1-hydroxypropyl)benzene-1,2-diol
  • Nordefrin (-)-form
  • LevonordefrinCorbadrine
Show all 33 synonyms
  • Corbadrin
  • Corbadrine (INN)
  • l-Cobefrin
  • Nordefrin, (-)-
  • 3,4-Dihydroxynorephedrin
  • 1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)-, (R-(R*,S*))-
  • alpha-Me-NE
  • Neo-cobefrin (TN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
183.21 g/molcalc.
Exact mass
183.0895 Dacalc.
LogP (octanol/water)
0.48calc.
Topological polar surface area
86.71 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
13calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H335May cause respiratory irritation.
Precautionary statements (20)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Levonordefrin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers
  • Siegfried Evionnaz SA
    Switzerland, Evionnaz ManufacturerUnclaimed profile
    LevonordefrinGrade, purity and minimum order on request
    Price on request
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  • AChemBlock
    United States, HaywardUnclaimed profile
    LevonordefrinGrade, purity and minimum order on request
    Price on request
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  • Avantor Inc.
    United States, Radnor ManufacturerUnclaimed profile
    LevonordefrinGrade, purity and minimum order on request
    Price on request
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  • EvitaChem
    China, BeijingUnclaimed profile
    LevonordefrinGrade, purity and minimum order on request
    Price on request
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  • OChem Inc
    United States, West ChicagoUnclaimed profile
    LevonordefrinGrade, purity and minimum order on request
    Price on request
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  • TimTec
    United States, KissimmeeUnclaimed profile
    LevonordefrinGrade, purity and minimum order on request
    Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 3 countries

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Levonordefrin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • adrenergic agent
  • adrenergic agonist
  • alpha-adrenergic agonist
  • alpha-adrenergic drug
  • cardiovascular drug
  • nasal decongestant
  • neurotransmitter agent
  • pharmaceutical
  • vasoconstrictor agent

Pharmacology

Levonordefrin is the levoisomer of nordefrin, a synthetic catecholamine and norepinephrine derivative with sympathomimetic and antihypertensive effects. Levonordefrin's antihypertensive effect is exerted through activation of alpha 2-adrenergic receptors in the cardiovascular control center of the CNS thereby suppressing the sympathetic output from the brain and subsequently lowering blood pressure. Levonordefrin binds to and activates peripheral alpha 2- adrenergic receptors, thereby causing vasoconstriction.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Levonordefrin is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Levonordefrin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Levonordefrin, based on the data on this page

What is Levonordefrin?

Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S.

What is the CAS number of Levonordefrin?

The CAS registry number of Levonordefrin is 829-74-3. Other or deprecated CAS numbers: 74812-63-8.

What is the molecular formula and weight of Levonordefrin?

The molecular formula of Levonordefrin is C9H13NO3 and its molar mass is 183.21 g/mol.

What is Levonordefrin used for?

Known uses and roles of Levonordefrin include building blocks in research and laboratory, screening compounds in research and laboratory, adrenergic agent, adrenergic agonist, alpha-adrenergic agonist and 6 more.

Is Levonordefrin hazardous?

Levonordefrin carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Levonordefrin?

Levonordefrin is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Levonordefrin?

CompoundList lists 6 suppliers of Levonordefrin in United States, Switzerland and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Levonordefrin?

Suppliers quote Levonordefrin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Levonordefrin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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