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Heterocyclic building blocks

Mephobarbital

Also known as Methylphenobarbital, Mephobarbitone, Metylfenemal

CAS 115-38-8Formula C13H14N2O3Molar mass 246.27 g/molEC 204-085-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe) Prohibited, not for trade
Why it is not for trade
Mephobarbital chemical structure, C13H14N2O3, CAS 115-38-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White crystals from water
Melting point
176 °C
Solubility
Slightly soluble in cold water, freely soluble in hot water or in alcohol.
HS code
293353
Category
Heterocyclic building blocks

What is Mephobarbital?

Plain description, key identifiers and synonyms

Mephobarbital is a member of the class of barbiturates, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by ethyl and phenyl groups. It has a role as an anticonvulsant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione
CAS number
115-38-8 CAS number cross-checked
EC number
204-085-7
Molecular formula
C13H14N2O3
UNII
5NC67NU76B
MDL number
MFCD00057563
InChIKey
ALARQZQTBTVLJV-UHFFFAOYSA-N
InChI
InChI=1S/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18)
SMILES (canonical and isomeric)
CCC1(C(=O)NC(=O)N(C1=O)C)C2=CC=CC=C2

Synonyms

  • Methylphenobarbital
  • Mephobarbitone
  • Metylfenemal
  • Mebaral
  • Methylphenobarbitone
  • Enphenemal
  • N-Methylphenobarbital
  • Isonal
  • Menta-Bal
  • Phemetone
  • Phemiton
  • 1-Methylphenobarbital
  • Methylphenobarbitonum
  • Metilfenobarbital
  • Methylphenobarbitalum
  • 5-Ethyl-1-methyl-5-phenylbarbituric acid
  • N-Methylethylphenylbarbituric acid
  • N-Methyl-5-phenyl-5-ethylbarbital
  • 5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione
  • Mephobarbital civ
  • 1-Methyl-5-ethyl-5-phenylbarbituric acid
  • 5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-1-methyl-5-phenyl-
  • 1-Methyl-5-phenyl-5-ethylbarbituric acid
  • 5-Phenyl-5-ethyl-3-methylbarbituric acid
Show all 38 synonyms
  • Barbituric acid, 5-ethyl-1-methyl-5-phenyl-
  • 5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione
  • Prominal
  • Enfenemal
  • Mephytal
  • Morbusan
  • Phemitone
  • Metyna
  • Methyl-calminal
  • N-Methylphenolbarbitol
  • Methylphenylbarbituric acid
  • Methylphenolbarbital
  • Isonal (roussel)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White crystals from waterexp.
Taste
Tastelessexp.
Melting point
176 °Cexp.
Solubility
Slightly soluble in cold water, freely soluble in hot water or in alcohol.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
246.27 g/molcalc.
Exact mass
246.1004 Dacalc.
LogP (octanol/water)
1.04calc.
Topological polar surface area
66.48 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.31calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NC(=O)C(c2ccccc2)C(=O)N1

O=C1NC(=O)C(c2ccccc2)C(=O)N1

2 rings, 15 atoms, the 5-Phenylbarbituric acid ring system.

176 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Mephobarbital suppliers

Trading restrictions apply to this substance

Psychotropic substance

Mephobarbital is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.53 (barbiturates)

Our policy on controlled substances

Mephobarbital price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

DEA /schedule IV /controlled substance.

Therapeutic category: Anticonvulsant, sedative, hypnotic.

Pharmacological actions

  • Anticonvulsants
  • GABA Modulators
  • Hypnotics and Sedatives

Roles

  • anticonvulsant
  • central nervous system depressant
  • central nervous system drug
  • pharmaceutical

How it is made

Phenobarbital + dimethyl sulfate (methylation)

The 5,5-disubstituted barbituric acids are still synthesized by the classical condensation of substituted malonic esters, malonic amides, or cyanoacetic esters with urea, thiourea, guanidine, or dicyanodiamide, followed by the hydrolysis of the resulting imino- or cyanobarbiturate. (5,5-Disubstituted barbituric acids)

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Mephobarbital is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.53 (barbiturates)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mephobarbital is traded under.

HS 2933.53Exact HS code

Allobarbital (INN), amobarbital (INN), barbital (INN), butalbital (INN), butobarbital…

World exports in 2024
$38.3M
+53.4% vs 2023, imports $32M
2019 to 2024
Top exporters
  1. Ireland45.2%
  2. Germany19.5%
  3. China8.8%
Top importers
  1. United States19.2%
  2. Italy16.9%
  3. Netherlands14.7%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Mephobarbital is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mephobarbital, based on the data on this page

What is Mephobarbital?

Mephobarbital is a member of the class of barbiturates, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by ethyl and phenyl groups. It has a role as an anticonvulsant.

What is the CAS number of Mephobarbital?

The CAS registry number of Mephobarbital is 115-38-8.

What is the molecular formula and weight of Mephobarbital?

The molecular formula of Mephobarbital is C13H14N2O3 and its molar mass is 246.27 g/mol.

What is Mephobarbital used for?

DEA /schedule IV /controlled substance. Therapeutic category: Anticonvulsant, sedative, hypnotic.

Is Mephobarbital hazardous?

Mephobarbital carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Mephobarbital?

Mephobarbital is usually classified under HS code 293353 (Allobarbital (INN), amobarbital (INN), barbital (INN), butalbital (INN), butobarbital…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Mephobarbital on CompoundList?

No. Mephobarbital is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Mephobarbital

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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