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Screening compounds

Mk-0249

Also known as MK 0249, 2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one, 2-Methyl-3-(4-(3-pyrrolidin-1-ylpropoxy)phenyl)-5-(trifluoromethyl)quinazolin-4-one

CAS 1167574-41-5Formula C23H24F3N3O2Molar mass 431.46 g/mol
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Mk-0249 chemical structure, C23H24F3N3O2, CAS 1167574-41-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1167574-41-5
Formula
C23H24F3N3O2
Molar mass
431.46 g/mol
HS code
293359
Category
Screening compounds

What is Mk-0249?

Plain description, key identifiers and synonyms

Mk-0249 is a chemical substance with the molecular formula C23H24F3N3O2 and a molar mass of 431.46 g/mol. Its CAS registry number is 1167574-41-5. The IUPAC name is 2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one
CAS number
1167574-41-5 CAS number cross-checkedOther or deprecated CAS: 862309-06-6
Molecular formula
C23H24F3N3O2
UNII
KF50235Q04
MDL number
MFCD31382164
InChIKey
DDDZBLNULGDPGA-UHFFFAOYSA-N
InChI
InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3
SMILES (canonical and isomeric)
CC1=NC2=CC=CC(=C2C(=O)N1C3=CC=C(C=C3)OCCCN4CCCC4)C(F)(F)F

Synonyms

  • MK 0249
  • 2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one
  • 2-Methyl-3-(4-(3-pyrrolidin-1-ylpropoxy)phenyl)-5-(trifluoromethyl)quinazolin-4-one
  • 2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-4-one
  • 2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-5-(trifluoromethyl)quinazolin-4(3h)-one
  • 2-Methyl-3-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-5-(trifluoromethyl)quinazolin-4(3H)-one
  • MK-0249 free base
  • 2-methyl-3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone
  • 2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
431.46 g/molcalc.
Exact mass
431.1821 Dacalc.
LogP (octanol/water)
4.58calc.
Topological polar surface area
47.36 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
6calc.
Heavy atoms
31calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.39calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c2ccccc2ncn1-c1ccc(OCCCN2CCCC2)cc1

O=c1c2ccccc2ncn1-c1ccc(OCCCN2CCCC2)cc1

4 rings, 26 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Mk-0249 suppliers

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Mk-0249 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antipsychotic agent
  • central nervous system depressant
  • central nervous system drug
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mk-0249 is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Mk-0249 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mk-0249, based on the data on this page

What is Mk-0249?

Mk-0249 is a chemical substance with the molecular formula C23H24F3N3O2 and a molar mass of 431.46 g/mol. Its CAS registry number is 1167574-41-5. The IUPAC name is 2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one.

What is the CAS number of Mk-0249?

The CAS registry number of Mk-0249 is 1167574-41-5. Other or deprecated CAS numbers: 862309-06-6.

What is the molecular formula and weight of Mk-0249?

The molecular formula of Mk-0249 is C23H24F3N3O2 and its molar mass is 431.46 g/mol.

What is Mk-0249 used for?

Known uses and roles of Mk-0249 include building blocks in research and laboratory, screening compounds in research and laboratory, antipsychotic agent, central nervous system depressant, central nervous system drug and 3 more.

Is Mk-0249 hazardous?

No GHS hazard classification for Mk-0249 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mk-0249?

Mk-0249 is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mk-0249?

Post a free request on CompoundList and suppliers of Mk-0249 will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Mk-0249?

Suppliers quote Mk-0249 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mk-0249

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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