Ns-2359 (CAS 195875-68-4): price, suppliers and safety

What is Ns-2359?

Plain description, key identifiers and synonyms

Ns-2359 is a chemical substance with the molecular formula C16H21Cl2NO and a molar mass of 314.26 g/mol. Its CAS registry number is 195875-68-4. The IUPAC name is (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
CAS number: 195875-68-4 CAS number cross-checked
Molecular formula: C₁₆H₂₁Cl₂NO
UNII: 76H76554PA
InChIKey: PGYDXVBZYKQYCS-VPWBDBDCSA-N
InChI: InChI=1S/C16H21Cl2NO/c1-19-11-4-6-16(19)13(9-20-2)12(8-11)10-3-5-14(17)15(18)7-10/h3,5,7,11-13,16H,4,6,8-9H2,1-2H3/t11-,12+,13+,16+/m0/s1
Canonical SMILES: COCC1C(c2ccc(Cl)c(Cl)c2)CC2CCC1N2C
Isomeric SMILES: CN1[C@H]2CC[C@@H]1[C@@H]([C@H](C2)C3=CC(=C(C=C3)Cl)Cl)COC

Synonyms

GSK-372,475
NS 2359
8-Azabicyclo(3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-methyl-, (1R,2R,3S,5S)-
(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
8-Azabicyclo(3.2.1)octane, 3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-methyl-, (1R,2R,3S,5S)-
(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-methyl-8-azabicyclo(3.2.1)octane
NS-2359 free base
GSK 372475
(1R,2R,3S)-2-Methoxymethyl-3-(3,4-dichlorophenyl)tropane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	314.26 g/molcalc.
Exact mass	313.10 Dacalc.
LogP (octanol/water)	4.21calc.
Topological polar surface area	12.47 Å²calc.
Hydrogen bond donors	0calc.
Hydrogen bond acceptors	2calc.
Rotatable bonds	3calc.
Heavy atoms	20calc.
Rings	3calc.
Aromatic rings	1calc.
Fraction sp3 carbons	0.63calc.
Formal charge	0calc.
Stereocentres	4calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

c1ccc(C2CC3CCC(C2)N3)cc1

3 rings, 14 atoms, the 3-Phenyl-8-azabicyclo[3.2.1]octane ring system.

177 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Ns-2359 suppliers

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Ns-2359 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Roles

antidepressant
central nervous system drug
pharmaceutical
psychotropic drug

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ns-2359 is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024

$12.1B

−31.0% vs 2023, imports $28.8B

2019 to 2024

Top exporters

China30.5%
India * partner reported16.3%
Ireland9.0%

Top importers

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ns-2359 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

3-(3,4-Dichlorophenyl)-2-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane chemical structure, C16H21Cl2NO, CAS 195875-98-0

3-(3,4-Dichlorophenyl)-2-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane195875-98-0C₁₆H₂₁Cl₂NO

(Rac)-GSK 372475 chemical structure, C16H21Cl2NO

(Rac)-GSK 372475C₁₆H₂₁Cl₂NO

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane chemical structure, C17H23Cl2NO, CAS 402856-42-2

Tesofensine chemical structure, C17H23Cl2NO, CAS 195875-84-4

NS-2359 citrate chemical structure, C22H29Cl2NO8, CAS 195875-69-5

75% similar

NS-2359 citrate195875-69-5C₂₂H₂₉Cl₂NO₈

(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-methanol chemical structure, C15H19Cl2NO

(1R,2R,3S)-2-Hydroxymethyl-3-(3,4-dichlorophenyl)tropane chemical structure, C15H19Cl2NO, CAS 173667-94-2

((1R,5S)-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl)methanol chemical structure, C15H19Cl2NO

RTI-111 free base chemical structure, C16H19Cl2NO2, CAS 143965-99-5

Methyl (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate chemical structure, C16H19Cl2NO2, CAS 157239-71-9

Tesofensine citrate chemical structure, C23H31Cl2NO8, CAS 861205-83-6

8-Azabicyclo(3.2.1)octane-2-carboxaldehyde, 3-(3,4-dichlorophenyl)-8-methyl-, O-methyloxime, (c(Z),1R,2R,3S,5S)- chemical structure, C16H20Cl2N2O, CAS 173830-25-6

Same formula isomers

Different compounds that share this molecular formula

All isomers

1-(3,4-Dichlorophenyl)-2-piperidin-1-yl-pentan-1-one chemical structure, C16H21Cl2NO, CAS 850352-64-6

1-(3,4-Dichlorophenyl)-2-piperidin-1-yl-pentan-1-one850352-64-6C₁₆H₂₁Cl₂NO

3,4-Dichloro-N,N-cyclohexylmethylcathinone chemical structure, C16H21Cl2NO, CAS 2741594-30-7

3,4-Dichloro-N,N-cyclohexylmethylcathinone2741594-30-7C₁₆H₂₁Cl₂NO

(2e)-4-Chloro-N-[(4-chlorophenyl)methyl]-N-(2-methylpropyl)pent-2-enamide chemical structure, C16H21Cl2NO, CAS 222846-51-7

(2e)-4-Chloro-N-[(4-chlorophenyl)methyl]-N-(2-methylpropyl)pent-2-enamide222846-51-7C₁₆H₂₁Cl₂NO

3-Cyclohexyl-N-(3,4-dichlorobenzyl)propanamide chemical structure, C16H21Cl2NO, CAS 548790-39-2

3-Cyclohexyl-N-(3,4-dichlorobenzyl)propanamide548790-39-2C₁₆H₂₁Cl₂NO

3-(4-Chlorophenyl)-5-(cyclohex-3-en-1-yl)pyrrolidin-3-ol--hydrogen chloride (1/1) chemical structure, C16H21Cl2NO, CAS 5075-95-6

3-(4-Chlorophenyl)-5-(cyclohex-3-en-1-yl)pyrrolidin-3-ol--hydrogen chloride (1/1)5075-95-6C₁₆H₂₁Cl₂NO

8-Chloro-N-ethyl-5-methoxy-N-(prop-2-yn-1-yl)-1,2,3,4-tetrahydronaphthalen-1-amine--hydrogen chloride (1/1) chemical structure, C16H21Cl2NO, CAS 63978-82-5

8-Chloro-N-ethyl-5-methoxy-N-(prop-2-yn-1-yl)-1,2,3,4-tetrahydronaphthalen-1-amine--hydrogen chloride (1/1)63978-82-5C₁₆H₂₁Cl₂NO

1-(3,4-Dichlorophenyl)-N-ethyl-N-methylcyclohexanecarboxamide chemical structure, C16H21Cl2NO, CAS 944351-53-5

1-(3,4-Dichlorophenyl)-N-ethyl-N-methylcyclohexanecarboxamide944351-53-5C₁₆H₂₁Cl₂NO

1(2H)-Naphthalenone, 3,4-dihydro-7-chloro-2-(piperidinomethyl)-, hydrochloride chemical structure, C16H21Cl2NO, CAS 93017-48-2

1(2H)-Naphthalenone, 3,4-dihydro-7-chloro-2-(piperidinomethyl)-, hydrochloride93017-48-2C₁₆H₂₁Cl₂NO

Ethylamine, N-(2-chloroethyl)-N-(1-naphthyloxyethyl)-, hydrochloride chemical structure, C16H21Cl2NO, CAS 63917-97-5

Ethylamine, N-(2-chloroethyl)-N-(1-naphthyloxyethyl)-, hydrochloride63917-97-5C₁₆H₂₁Cl₂NO

Ethylamine, N-(2-chloroethyl)-N-(2-naphthyloxyethyl)-, hydrochloride chemical structure, C16H21Cl2NO, CAS 63917-98-6

Ethylamine, N-(2-chloroethyl)-N-(2-naphthyloxyethyl)-, hydrochloride63917-98-6C₁₆H₂₁Cl₂NO

9-(3,4-Dichlorophenoxy)-3-azaspiro[5.5]undecane chemical structure, C16H21Cl2NO, CAS 918644-64-1

9-(3,4-Dichlorophenoxy)-3-azaspiro[5.5]undecane918644-64-1C₁₆H₂₁Cl₂NO

1-(6-Chloronaphthalen-1-yl)-2-(diethylamino)ethanol, hydrochloride chemical structure, C16H21Cl2NO, CAS 5471-10-3

1-(6-Chloronaphthalen-1-yl)-2-(diethylamino)ethanol, hydrochloride5471-10-3C₁₆H₂₁Cl₂NO

Guides for buyers

Practical guides that help when you source, ship or handle Ns-2359

Ns-2359

Key facts

What is Ns-2359?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Ns-2359 suppliers

Ns-2359 price

Uses and applications

Industries and functions

Roles

Regulatory status

HS code and trade data

Global trade

Guides for buyers

Get quotes for Ns-2359

Key facts

What is Ns-2359?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Ns-2359 suppliers

Ns-2359 price

Uses and applications

Industries and functions

Roles

Regulatory status

HS code and trade data

Global trade

Related chemicals

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Guides for buyers

Get quotes for Ns-2359