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Aromatic building blocks

Phenformin

Also known as Phenformine, Fenformin, Fenformina

CAS 114-86-3Formula C10H15N5Molar mass 205.27 g/molEC 204-057-4
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Phenformin chemical structure, C10H15N5, CAS 114-86-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
114-86-3
Formula
C10H15N5
Molar mass
205.27 g/mol
Solubility
Crystals from isopropanol, pH (0.1 Molar aq soln): 6.7, MP 175-178 °C, Sol in water /Hyd…
HS code
292529
Category
Aromatic building blocks

What is Phenformin?

Plain description, key identifiers and synonyms

Phenformin is a member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidosis. It has a role as a geroprotector, a hypoglycemic agent and an antineoplastic agent. It is functionally related to a biguanide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(diaminomethylidene)-2-(2-phenylethyl)guanidine
CAS number
114-86-3 CAS number cross-checked
EC number
204-057-4
Molecular formula
C10H15N5
UNII
DD5K7529CE
MDL number
MFCD00242966
InChIKey
ICFJFFQQTFMIBG-UHFFFAOYSA-N
InChI
InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
SMILES (canonical and isomeric)
C1=CC=C(C=C1)CCN=C(N)N=C(N)N

Synonyms

  • Phenformine
  • Fenformin
  • Fenformina
  • Pedg
  • Phenethyldiguanide
  • Phenformix
  • Fenormin
  • Phenylethylbiguanide
  • Cronoformin
  • Fenfoduron
  • Glukopostin
  • Debeone
  • Diabis
  • Dibiraf
  • Dibotin
  • Glyphen
  • Retardo
  • Imidodicarbonimidic diamide, N-(2-phenylethyl)-
  • 1-Phenethylbiguanide
  • Feguanide
  • Lentobetic
  • Normoglucina
  • Azucaps
  • beta-PEBG
  • Debinyl
Show all 35 synonyms
  • Dibein
  • Insoral
  • DB Comb
  • D Bretard
  • beta-Phenethylbiguanide
  • Phenforminum
  • Biguanide, 1-phenethyl-
  • N'-beta-Phenethylformamidinylliminourea
  • 1-carbamimidamido-N-(2-phenylethyl)methanimidamide
  • N-Phenethylbiguanide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
Crystals from isopropanol, pH (0.1 Molar aq soln): 6.7, MP 175-178 °C, Sol in water /Hydrochloride/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
205.27 g/molcalc.
Exact mass
205.1327 Dacalc.
LogP (octanol/water)
-0.18calc.
Topological polar surface area
102.8 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
3calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.2calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Phenformin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 13 suppliers
13 of 13 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

13 suppliers in 5 countries

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Phenformin price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antidiabetic.

An oral hypoglycemic drug, used as the hydrochloride salt.

Pharmacological actions

  • Hypoglycemic Agents

Roles

  • antineoplastic agent
  • geroprotector
  • hypoglycemic agent
  • pharmaceutical
  • protective agent

Pharmacology

Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Phenformin is not used clinically due to the high risk of lactic acidosis that is associated with its use.

How it is made

Equimolar quantities of phenethylamine & dicyanodiamide (cyanoguanidine) are mixed & neutralized with aq hcl. Water is distilled off until mixt boils (@ about 129 deg) after reflux is allowed to continue for 3 hr. Crude product may be crystallized from isopropanol. Us patent 2,961,377. (Hydrochloride)

Prepn from beta-phenethylamine hydrochloride & dicyandiamide

Shapiro, Freedman, US pats 2,961,377 and 3,057,780 (1960 and 1962, both to USV).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phenformin is traded under.

HS 2925.29Indicative HS code

Imines and their derivatives, salts thereof, other

World exports in 2024
$1.8B
+12.4% vs 2023, imports $1.84B
2019 to 2024
Top exporters
  1. China35.9%
  2. France * partner reported15.5%
  3. Germany9.1%
Top importers
  1. United States13.3%
  2. China13.0%
  3. Brazil9.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Phenformin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phenformin, based on the data on this page

What is Phenformin?

Phenformin is a member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidosis.

What is the CAS number of Phenformin?

The CAS registry number of Phenformin is 114-86-3.

What is the molecular formula and weight of Phenformin?

The molecular formula of Phenformin is C10H15N5 and its molar mass is 205.27 g/mol.

What is Phenformin used for?

Therapeutic category: Antidiabetic. An oral hypoglycemic drug, used as the hydrochloride salt.

Is Phenformin hazardous?

No GHS hazard classification for Phenformin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Phenformin?

Phenformin is usually classified under HS code 292529 (Imines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phenformin?

CompoundList lists 13 suppliers of Phenformin in China, United States, Hong Kong, Germany and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Phenformin?

Suppliers quote Phenformin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phenformin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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