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Heterocyclic building blocks

Phenprocoumon

Also known as Phenprocoumarol, Phenprocoumarole, 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one

CAS 435-97-2Formula C18H16O3Molar mass 280.32 g/molEC 207-108-9
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 55 suppliers listed
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Phenprocoumon chemical structure, C18H16O3, CAS 435-97-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Fine white crystalline powder
Melting point
179 to 180
Solubility
PRACTICALLY INSOL IN H2O, SOL IN CHLOROFORM & METHANOL
HS code
293220
Category
Heterocyclic building blocks
Illustrative photo, off-white powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Phenprocoumon?

Plain description, key identifiers and synonyms

Phenprocoumon is a hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenylpropyl group. It has a role as an anticoagulant and an EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor.

Phenprocoumon is a pharmaceutical drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-hydroxy-3-(1-phenylpropyl)chromen-2-one
CAS number
435-97-2 CAS number cross-checkedOther or deprecated CAS: 5999-41-7, 70206-44-9
EC number
207-108-9
Molecular formula
C18H16O3
UNII
Q08SIO485D
MDL number
MFCD00865273
InChIKey
DQDAYGNAKTZFIW-UHFFFAOYSA-N
InChI
InChI=1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,19H,2H2,1H3
SMILES (canonical and isomeric)
CCC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

Synonyms

  • Phenprocoumarol
  • Phenprocoumarole
  • 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
  • Liquamar
  • Marcumar
  • Marcoumar
  • Fencumar
  • Falithrom
  • Phenprocoumone
  • Phenprocumone
  • Fenprocumone
  • Phenprocoumonum
  • 3-(1-Phenylpropyl)-4-hydroxycoumarin
  • 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one
  • fenprocumon
  • 3-(alpha-Ethylbenzyl)-4-hydroxycoumarin
  • 3-(1'-Phenyl-propyl)-4-oxycoumarin
  • Ro 1-4849
  • 3-(alpha-Phenylpropyl)-4-hydroxycoumarin
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-phenylpropyl)-
  • Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy-
  • Phenprocoumalol
  • 5-18-02-00343 (Beilstein Handbook Reference)
  • Phenylpropylhydroxycumarinum
  • 4-hydroxy-3-(1-phenylpropyl)chromen-2-one
Show all 32 synonyms
  • 2-hydroxy-3-(1-phenylpropyl)-4H-chromen-4-one
  • Phenprocoumon (Marcumar)
  • Phenprocumonum
  • Fenprocoumona
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-1-phenylpropyl]-
  • Liquamar (TN)
  • Phenprocoumon (USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Fine white crystalline powderexp.
Odour
ODORLESS OR HAS SLIGHT ODORexp.
Melting point
179 to 180exp.
Solubility
PRACTICALLY INSOL IN H2O, SOL IN CHLOROFORM & METHANOLexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
280.32 g/molcalc.
Exact mass
280.1099 Dacalc.
LogP (octanol/water)
4.04calc.
Topological polar surface area
50.44 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.17calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1oc2ccccc2cc1Cc1ccccc1

O=c1oc2ccccc2cc1Cc1ccccc1

3 rings, 18 atoms, the 3-Benzyl-2H-1-benzopyran-2-one ring system.

221 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301 + H311 + H331Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.
  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H331Toxic if inhaled.
  • H360May damage fertility or the unborn child.
  • H361dSuspected of damaging the unborn child.
  • H362May cause harm to breast-fed children.
  • H370Causes damage to organs.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (27)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Phenprocoumon suppliers

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All 55 suppliers
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Where suppliers are based

55 suppliers in 12 countries

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Phenprocoumon price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anticoagulants

Roles

  • anticoagulant
  • antineoplastic agent
  • enzyme inhibitor
  • hematologic agent
  • pharmaceutical

Pharmacology

Phenprocoumon is a Vitamin K Antagonist. The mechanism of action of phenprocoumon is as a Vitamin K Inhibitor.

How it is made

Prepn: Grussner, Balthasar, US 2723276 (1955 to Hoffmann-La Roche), ... US 2872457 (1959 to Wisconsin Alumni Research Foundation), GB 805748 (1958 to Geigy), ... Resolution: Preis et al, US 3239529 (1966 to Wisconsin Alumni Research Foundation).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Phenprocoumon (INN), Ref no: 273, Annex ref: II/273

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phenprocoumon is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Phenprocoumon is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phenprocoumon, based on the data on this page

What is Phenprocoumon?

Phenprocoumon is a hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenylpropyl group. It has a role as an anticoagulant and an EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor.

What is the CAS number of Phenprocoumon?

The CAS registry number of Phenprocoumon is 435-97-2. Other or deprecated CAS numbers: 5999-41-7, 70206-44-9.

What is the molecular formula and weight of Phenprocoumon?

The molecular formula of Phenprocoumon is C18H16O3 and its molar mass is 280.32 g/mol.

What is Phenprocoumon used for?

Use classes: Pharmaceuticals.

Is Phenprocoumon hazardous?

Phenprocoumon carries the GHS signal word "Danger". Main hazards: toxic if swallowed. toxic in contact with skin. toxic if inhaled, toxic if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Phenprocoumon?

Phenprocoumon is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phenprocoumon?

CompoundList lists 55 suppliers of Phenprocoumon in United States, China, United Kingdom, Hong Kong and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Phenprocoumon?

Suppliers quote Phenprocoumon on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phenprocoumon

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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