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Oncology and immunology drugs

Pomalidomide

Also known as Actimid, Pomalyst, Imnovid

CAS 19171-19-8Formula C13H11N3O4Molar mass 273.25 g/molEC 805-902-5
GHS signal word: Danger. Pictograms: Serious health hazard 105 suppliers listed Drug substance
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Pomalidomide chemical structure, C13H11N3O4, CAS 19171-19-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
19171-19-8
Formula
C13H11N3O4
Appearance
Solid yellow powder
Solubility
Limited to low solubility into organic solvents low solubility in all pH solutions (abou…
HS code
292519
Category
Oncology and immunology drugs
Illustrative photo, yellow pigment powder in an open fibre drum in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Pomalidomide?

Plain description, key identifiers and synonyms

Pomalidomide is an aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an immunomodulator. It is a member of isoindoles, an aromatic amine, a dicarboximide and a member of piperidones. It is functionally related to a thalidomide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CAS number
19171-19-8 CAS number cross-checkedOther or deprecated CAS: 443919-33-3
EC number
805-902-5
Molecular formula
C13H11N3O4
UNII
D2UX06XLB5
MDL number
MFCD12756407
InChIKey
UVSMNLNDYGZFPF-UHFFFAOYSA-N
InChI
InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
SMILES (canonical and isomeric)
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N

Synonyms

  • Actimid
  • Pomalyst
  • Imnovid
  • 4-Aminothalidomide
  • 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
  • 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • IMID-3
  • 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
  • IMiD 3
  • CC 4047
  • IMiD3
  • Pomalidomida
  • 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
  • Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-
  • pomalidomidum
  • 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • Pomalidomide (CC-4047)
  • 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
  • 4-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • Pomalidomid
  • Pomalidomide?
  • Pomalyst (TN)
  • IMiD1
  • Pomalidomide (Standard)
Show all 28 synonyms
  • 4-amino-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione
  • 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
  • 3-Aminophthalimidoglutarimide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Solid yellow powderexp.
Solubility
Limited to low solubility into organic solvents low solubility in all pH solutions (about 0.01 mg/mL)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
273.25 g/molcalc.
Exact mass
273.075 Dacalc.
LogP (octanol/water)
-0.33calc.
Topological polar surface area
109.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

3 rings, 19 atoms, the Thalidomide ring system.

1,721 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H360FDMay damage fertility. May damage the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (7)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pomalidomide suppliers

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All 105 suppliers
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Where suppliers are based

105 suppliers in 15 countries

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Pomalidomide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Angiogenesis Inhibitors, Immunologic Factors.

Industries and functions

Pharmacological actions

  • Angiogenesis Inhibitors
  • Immunologic Factors

Roles

  • angiogenesis inhibitor
  • anti-anaemic agent
  • antifibrotic agent
  • antineoplastic agent
  • immunomodulator
  • pharmaceutical

Pharmacology

Pomalidomide is a Thalidomide Analog.

How it is made

Pomalidomide is synthesized in two main steps using commercially available well defined starting materials with acceptable specifications. The first step consists of a coupling reaction in which the starting materials react to form crude pomalidomide. The second step is a purification process consisting on filtration, crystallization and drying to obtain the final drug substance.

Preparation: G. W. Muller et al., World Intellectual Property Organization patent 9803502, eidem, United States of America patent 6335349 (1998, 2002 both to Celgene).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pomalidomide is traded under.

HS 2925.19Indicative HS code

Imides and their derivatives, salts thereof, other

World exports in 2024
$295M
+11.7% vs 2023, imports $348M
2019 to 2024
Top exporters
  1. China29.7%
  2. Japan22.7%
  3. United Kingdom10.0%
Top importers
  1. United States12.7%
  2. Brazil12.6%
  3. China10.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Pomalidomide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pomalidomide, based on the data on this page

What is Pomalidomide?

Pomalidomide is an aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an immunomodulator.

What is the CAS number of Pomalidomide?

The CAS registry number of Pomalidomide is 19171-19-8. Other or deprecated CAS numbers: 443919-33-3.

What is the molecular formula and weight of Pomalidomide?

The molecular formula of Pomalidomide is C13H11N3O4 and its molar mass is 273.25 g/mol.

What is Pomalidomide used for?

Angiogenesis Inhibitors, Immunologic Factors.

Is Pomalidomide hazardous?

Pomalidomide carries the GHS signal word "Danger". Main hazards: may damage fertility. may damage the unborn child, suspected of damaging fertility or the unborn child, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pomalidomide?

Pomalidomide is usually classified under HS code 292519 (Imides and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pomalidomide?

CompoundList lists 105 suppliers of Pomalidomide in China, United States, India, Germany and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Pomalidomide in India?

20 suppliers in India list Pomalidomide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Pomalidomide?

Suppliers quote Pomalidomide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pomalidomide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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