CompoundList
Sign in
Aromatic building blocks

4-Hydroxy thalidomide

Also known as 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione, 4-Hydroxythalidomide, Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-hydroxy-

CAS 5054-59-1Formula C13H10N2O5Molar mass 274.23 g/molEC 826-734-9
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 9 suppliers listed
Get quotes Compare 9 suppliers
4-Hydroxy thalidomide chemical structure, C13H10N2O5, CAS 5054-59-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
5054-59-1
Formula
C13H10N2O5
Molar mass
274.23 g/mol
EC number
826-734-9
HS code
292519
Category
Aromatic building blocks

What is 4-Hydroxy thalidomide?

Plain description, key identifiers and synonyms

4-Hydroxy thalidomide is a chemical substance with the molecular formula C13H10N2O5 and a molar mass of 274.23 g/mol. Its CAS registry number is 5054-59-1. The IUPAC name is 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione
CAS number
5054-59-1
EC number
826-734-9
Molecular formula
C13H10N2O5
UNII
J344NHC6VB
MDL number
MFCD03699892
InChIKey
XMPJICVFSDYOEG-UHFFFAOYSA-N
InChI
InChI=1S/C13H10N2O5/c16-8-3-1-2-6-10(8)13(20)15(12(6)19)7-4-5-9(17)14-11(7)18/h1-3,7,16H,4-5H2,(H,14,17,18)
SMILES (canonical and isomeric)
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)O

Synonyms

  • 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
  • 4-Hydroxythalidomide
  • Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-hydroxy-
  • 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-
  • 4-Hydroxy thalidomide, (+-)-
  • Thalidomide-4-OH
  • E3 ligase Ligand 2
  • Thalidomide-OH
  • 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione
  • 2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione
  • 4-Hydroxy thalidomide, (+/-)-
  • E3 ligase Ligand 2 (Thalidomide-OH)
  • 2-(2,6-dioxo-3-piperidyl)-4-hydroxy-isoindoline-1,3-dione
  • 2-(2,6-dioxopiperidin-3-yl)-4-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione
  • 4-Hydroxy-thalidomide
  • 3-Hydroxy Thalidomide
  • Cereblon ligand 2
  • E3 Ligase Ligand 2?
  • Thalidomide-4-OH, Cereblon ligand 2
  • US11059801, Compound D-1
  • US11059801, Compound D-57
  • 2-(2,6-Dioxo-piperidin-3-yl)-4-hydroxy-isoindole-1,3-dione
  • 4-hydroxy-2-(2,6-dioxo(3-piperidyl))isoindoline-1,3-dione
  • 4-hydroxy-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • 2-(2,6-dioxopiperidin-3-yl)-4-hydroxy-1H-isoindole-1,3(2H)-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
274.23 g/molcalc.
Exact mass
274.059 Dacalc.
LogP (octanol/water)
-0.21calc.
Topological polar surface area
103.8 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

3 rings, 19 atoms, the Thalidomide ring system.

1,721 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H361Suspected of damaging fertility or the unborn child.
  • H361dSuspected of damaging the unborn child.
Precautionary statements (14)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

4-Hydroxy thalidomide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 9 suppliers
9 of 9 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 2 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

4-Hydroxy thalidomide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 4-Hydroxy thalidomide is traded under.

HS 2925.19Indicative HS code

Imides and their derivatives, salts thereof, other

World exports in 2024
$295M
+11.7% vs 2023, imports $348M
2019 to 2024
Top exporters
  1. China29.7%
  2. Japan22.7%
  3. United Kingdom10.0%
Top importers
  1. United States12.7%
  2. Brazil12.6%
  3. China10.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 4-Hydroxy thalidomide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 4-Hydroxy thalidomide, based on the data on this page

What is 4-Hydroxy thalidomide?

4-Hydroxy thalidomide is a chemical substance with the molecular formula C13H10N2O5 and a molar mass of 274.23 g/mol. Its CAS registry number is 5054-59-1. The IUPAC name is 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione.

What is the CAS number of 4-Hydroxy thalidomide?

The CAS registry number of 4-Hydroxy thalidomide is 5054-59-1.

What is the molecular formula and weight of 4-Hydroxy thalidomide?

The molecular formula of 4-Hydroxy thalidomide is C13H10N2O5 and its molar mass is 274.23 g/mol.

What is 4-Hydroxy thalidomide used for?

Known uses and roles of 4-Hydroxy thalidomide include building blocks in research and laboratory and screening compounds in research and laboratory.

Is 4-Hydroxy thalidomide hazardous?

4-Hydroxy thalidomide carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, harmful in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 4-Hydroxy thalidomide?

4-Hydroxy thalidomide is usually classified under HS code 292519 (Imides and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 4-Hydroxy thalidomide?

CompoundList lists 9 suppliers of 4-Hydroxy thalidomide in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 4-Hydroxy thalidomide?

Suppliers quote 4-Hydroxy thalidomide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 4-Hydroxy thalidomide

Get quotes for 4-Hydroxy thalidomide

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell 4-Hydroxy thalidomide
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of 4-Hydroxy thalidomide with a 3D view, its CAS number and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/4-hydroxy-thalidomide-5054-59-1" title="4-Hydroxy thalidomide structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Aromatic building blocks or HS code 292519

9 suppliers
Free quotes, contact stays private
Get quotes