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Antibiotics and anti-infectives

Thalidomide

Also known as Thalomid, Contergan, Pantosediv

CAS 50-35-1Formula C13H10N2O4Molar mass 258.23 g/molEC 200-031-1
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 122 suppliers listed Drug substance
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Thalidomide chemical structure, C13H10N2O4, CAS 50-35-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Needles
Melting point
270 °C
Solubility
In water, approximately 2 × 10⁻⁴ mol/L, 45-60 mg/L at 25 °C
HS code
292519
Category
Antibiotics and anti-infectives
UN number
UN 2811
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Thalidomide?

Plain description, key identifiers and synonyms

2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione is a dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group. It is a member of piperidones and a member of phthalimides.

Thalidomide is an immunomodulatory drug known for its ability to cause birth defects.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CAS number
50-35-1 CAS number cross-checkedOther or deprecated CAS: 1012310-87-0, 2614-06-4, 841-67-8
EC number
200-031-1
Molecular formula
C13H10N2O4
UNII
4Z8R6ORS6L
MDL number
MFCD00153873
InChIKey
UEJJHQNACJXSKW-UHFFFAOYSA-N
InChI
InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
SMILES (canonical and isomeric)
C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O

Synonyms

  • Thalomid
  • Contergan
  • Pantosediv
  • Distaval
  • Softenon
  • Kevadon
  • Psychotablets
  • Algosediv
  • Calmorex
  • Neosedyn
  • Profarmil
  • Quetimid
  • Sedisperil
  • Imidene
  • Pangul
  • Talimol
  • Telagan
  • Imida-lab
  • Theophilcholine
  • Corronarobetin
  • Ectiluran
  • Enterosediv
  • Gastrinide
  • Neaufatin
  • Nerosedyn
Show all 39 synonyms
  • Neurosedin
  • Neurosedym
  • Noctosediv
  • Psycholiquid
  • Quietoplex
  • Sandormin
  • Shinnibrol
  • Telargean
  • Thalinette
  • Valgraine
  • Asmadion
  • Asmaval
  • Bonbrain
  • Calmore

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Needlesexp.
Melting point
270 °Cexp.
Solubility
In water, approximately 2 × 10⁻⁴ mol/L, 45-60 mg/L at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
258.23 g/molcalc.
Exact mass
258.0641 Dacalc.
LogP (octanol/water)
0.09calc.
Topological polar surface area
83.55 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
19calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

3 rings, 19 atoms. This chemical is the scaffold itself.

1,721 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H360May damage fertility or the unborn child.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Thalidomide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 122 suppliers
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Where suppliers are based

122 suppliers in 17 countries

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Thalidomide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Angiogenesis Inhibitors, Immunosuppressive Agents, Leprostatic Agents, Teratogens.

Pharmacological actions

  • Angiogenesis Inhibitors
  • Immunosuppressive Agents
  • Leprostatic Agents
  • Teratogens

Roles

  • analgesic
  • angiogenesis inhibitor
  • anti-HIV agent
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antibacterial drug
  • anticonvulsant
  • antiemetic
  • antifibrotic agent
  • antiinfective agent
  • antimicrobial drug
  • antimycobacterial drug
  • antineoplastic agent
  • antipsoriatic
  • antitussive
  • antiviral agent
  • central nervous system drug
  • dermatologic drug
  • immunomodulator
  • immunosuppressive agent
  • leprostatic drug
  • pharmaceutical
  • sedative
  • teratogenic agent

Pharmacology

The physiologic effect of thalidomide is by means of Decreased Immunologically Active Molecule Activity.

How it is made

Preparation: United Kingdom patent 768821 (1957 to Chemie Grunenthal)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Thalidomide (INN) and its salts, Ref no: 280, Annex ref: II/280
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Thalidomide is traded under.

HS 2925.19Indicative HS code

Imides and their derivatives, salts thereof, other

World exports in 2024
$295M
+11.7% vs 2023, imports $348M
2019 to 2024
Top exporters
  1. China29.7%
  2. Japan22.7%
  3. United Kingdom10.0%
Top importers
  1. United States12.7%
  2. Brazil12.6%
  3. China10.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Thalidomide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Thalidomide, based on the data on this page

What is Thalidomide?

2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione is a dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group. It is a member of piperidones and a member of phthalimides.

What is the CAS number of Thalidomide?

The CAS registry number of Thalidomide is 50-35-1. Other or deprecated CAS numbers: 1012310-87-0, 2614-06-4, 841-67-8.

What is the molecular formula and weight of Thalidomide?

The molecular formula of Thalidomide is C13H10N2O4 and its molar mass is 258.23 g/mol.

What is Thalidomide used for?

Angiogenesis Inhibitors, Immunosuppressive Agents, Leprostatic Agents, Teratogens.

Is Thalidomide hazardous?

Thalidomide carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Thalidomide?

Thalidomide is usually classified under HS code 292519 (Imides and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Thalidomide?

CompoundList lists 122 suppliers of Thalidomide in United States, China, India, Germany and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Thalidomide in India?

8 suppliers in India list Thalidomide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Thalidomide?

Suppliers quote Thalidomide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Thalidomide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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