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Central nervous system drugs

Procyclidine

Also known as Kemadrine, Tricoloid, Elorine

CAS 77-37-2Formula C19H29NOMolar mass 287.45 g/molEC 201-023-0
1 supplier listed
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Procyclidine chemical structure, C19H29NO, CAS 77-37-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
77-37-2
Formula
C19H29NO
Appearance
Crystals from petroleum ether
Melting point
85.5 to 86.5 °C
HS code
293399
Category
Central nervous system drugs
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Procyclidine?

Plain description, key identifiers and synonyms

Procyclidine is a tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3. It has a role as an antiparkinson drug, a muscarinic antagonist and an antidyskinesia agent. It is a tertiary alcohol and a member of pyrrolidines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
CAS number
77-37-2 CAS number cross-checked
EC number
201-023-0
Molecular formula
C19H29NO
UNII
C6QE1Q1TKR
InChIKey
WYDUSKDSKCASEF-UHFFFAOYSA-N
InChI
InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
SMILES (canonical and isomeric)
C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O

Synonyms

  • Kemadrine
  • Tricoloid
  • Elorine
  • Lergine
  • Vagosin
  • Arpicolin
  • Spamol
  • Procyklidin
  • Triciclidina
  • Metanin
  • Osnervan
  • Procidlidina
  • Prociclidina
  • Procyclidinum
  • 1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol
  • 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol
  • 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol
  • 1-PYRROLIDINEPROPANOL, alpha-CYCLOHEXYL-alpha-PHENYL-
  • 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride
  • (+-)-Procyclidine
  • Kemadrin
  • Prosyklidin
  • Triciloid
  • 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
  • Procyclidine (INN)
Show all 28 synonyms
  • Tricoloid, Tricyclamol, Vagosin
  • Procyclidine, >98%
  • 5-20-01-00250 (Beilstein Handbook Reference)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from petroleum etherexp.
Melting point
85.5 to 86.5 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
287.45 g/molcalc.
Exact mass
287.2249 Dacalc.
LogP (octanol/water)
3.94calc.
Topological polar surface area
23.47 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
5calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.68calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C(CCN2CCCC2)C2CCCCC2)cc1

c1ccc(C(CCN2CCCC2)C2CCCCC2)cc1

3 rings, 20 atoms.

17 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Procyclidine suppliers

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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

1 supplier in 1 country

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Procyclidine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Contraindicated for use in angle-closure glaucoma (Hydrochloride).

Anticholinergic.

Therapeutic category: Antiparkinsonian (Discontinued).

Procyclidine (is a) tertiary-amine muscarinic receptor antagonist that (gains) access to the CNS and can therefore be used when anticholinergics are indicated to treat parkinsonism and extrapyramidal side effects of antipsychotic drugs.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antiparkinson Agents
  • Muscarinic Antagonists

Roles

  • antidyskinesia agent
  • antiparkinson drug
  • cholinergic antagonist
  • cholinergic drug
  • muscarinic antagonist
  • neurotransmitter agent
  • pharmaceutical

Pharmacology

Procyclidine is an Anticholinergic. The mechanism of action of procyclidine is as a Cholinergic Antagonist.

How it is made

Preparation of free base and hydrochloride:...Adamson, US 2891890 (1959 Burroughs Wellcome). Preparation of methochloride: Bottorff, US 2826590 (1958 ro Lilly), Harfenist, Magnien, US 2842555 (1958) to Burroughs Wellcome).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Procyclidine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Procyclidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Procyclidine, based on the data on this page

What is Procyclidine?

Procyclidine is a tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3. It has a role as an antiparkinson drug, a muscarinic antagonist and an antidyskinesia agent. It is a tertiary alcohol and a member of pyrrolidines.

What is the CAS number of Procyclidine?

The CAS registry number of Procyclidine is 77-37-2.

What is the molecular formula and weight of Procyclidine?

The molecular formula of Procyclidine is C19H29NO and its molar mass is 287.45 g/mol.

What is Procyclidine used for?

Contraindicated for use in angle-closure glaucoma (Hydrochloride). Anticholinergic. Therapeutic category: Antiparkinsonian (Discontinued).

Is Procyclidine hazardous?

No GHS hazard classification for Procyclidine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Procyclidine?

Procyclidine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Procyclidine?

CompoundList lists 1 supplier of Procyclidine in India. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Procyclidine in India?

1 supplier in India list Procyclidine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Procyclidine?

Suppliers quote Procyclidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Procyclidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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