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Screening compounds

Relacorilant

Also known as 2-[(4aR)-1-(4-fluorophenyl)-6-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-1H,4H,4aH,5H,6H,7H,8H-pyrido[3,4-f]indazole-4a-carbonyl]-4-(trifluoromethyl)pyridine, relacorilantum, 2-((4aR)-1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-1H,4H,4aH,5H,6H,7H,8H-pyrido(3,4-f)indazole-4a-carbonyl)-4-(trifluoromethyl)pyridine

CAS 1496510-51-0Formula C27H22F4N6O3SMolar mass 586.57 g/mol
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Relacorilant chemical structure, C27H22F4N6O3S, CAS 1496510-51-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1496510-51-0
Formula
C27H22F4N6O3S
Molar mass
586.57 g/mol
HS code
293590
Category
Screening compounds

What is Relacorilant?

Plain description, key identifiers and synonyms

Relacorilant is an orally available antagonist of the glucocorticoid receptor (GR), with potential antineoplastic activity. Upon administration, relacorilant competitively binds to and blocks GRs. This inhibits the activity of GRs, and prevents both the translocation of the ligand-GR complexes to the nucleus and gene expression of GR-associated genes. This decreases the negative effects that result from excess levels of endogenous glucocorticoids, like those seen when tumors overproduce glucocorticoids. In addition, by binding to GRs and preventing their activity, inhibition with CORT125134 also inhibits the proliferation of GR-overexpressing cancer cells. GRs are overexpressed in certain tumor cell types and promote tumor cell proliferation.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)-2-pyridinyl]methanone
CAS number
1496510-51-0
Molecular formula
C27H22F4N6O3S
UNII
2158753C7E
InChIKey
WANIDIGFXJFFEL-SANMLTNESA-N
InChI
InChI=1S/C27H22F4N6O3S/c1-35-15-22(14-33-35)41(39,40)36-9-7-18-11-24-17(13-34-37(24)21-4-2-20(28)3-5-21)12-26(18,16-36)25(38)23-10-19(6-8-32-23)27(29,30)31/h2-6,8,10-11,13-15H,7,9,12,16H2,1H3/t26-/m0/s1
SMILES
CN1C=C(C=N1)S(=O)(=O)N2CCC3=CC4=C(C[C@@]3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F

Synonyms

  • 2-[(4aR)-1-(4-fluorophenyl)-6-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-1H,4H,4aH,5H,6H,7H,8H-pyrido[3,4-f]indazole-4a-carbonyl]-4-(trifluoromethyl)pyridine
  • relacorilantum
  • 2-((4aR)-1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-1H,4H,4aH,5H,6H,7H,8H-pyrido(3,4-f)indazole-4a-carbonyl)-4-(trifluoromethyl)pyridine
  • Lifyorli
  • [(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
  • Cort 125134
  • Relacorilant (USAN)
  • Lifyorli (TN)
  • compound 7
  • (R)-(1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)
  • [(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)-2-pyridinyl]methanone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
586.57 g/molcalc.
Exact mass
586.141 Dacalc.
LogP (octanol/water)
4.06calc.
Topological polar surface area
103 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
41calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(c1ccccn1)C12Cc3cnn(-c4ccccc4)c3C=C1CCN(S(=O)(=O)c1cn[nH]c1)C2

O=C(c1ccccn1)C12Cc3cnn(-c4ccccc4)c3C=C1CCN(S(=O)(=O)c1cn[nH]c1)C2

6 rings, 35 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Relacorilant suppliers

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Where suppliers are based

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Relacorilant price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Relacorilant is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Relacorilant is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Relacorilant, based on the data on this page

What is Relacorilant?

Relacorilant is an orally available antagonist of the glucocorticoid receptor (GR), with potential antineoplastic activity. Upon administration, relacorilant competitively binds to and blocks GRs.

What is the CAS number of Relacorilant?

The CAS registry number of Relacorilant is 1496510-51-0.

What is the molecular formula and weight of Relacorilant?

The molecular formula of Relacorilant is C27H22F4N6O3S and its molar mass is 586.57 g/mol.

What is Relacorilant used for?

Known uses and roles of Relacorilant include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, pharmaceutical and antineoplastic agents.

Is Relacorilant hazardous?

No GHS hazard classification for Relacorilant is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Relacorilant?

Relacorilant is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Relacorilant?

CompoundList lists 1 supplier of Relacorilant in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Relacorilant?

Suppliers quote Relacorilant on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Relacorilant

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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