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Heterocyclic building blocks

Rogletimide

Also known as Pyridoglutethimide, Rogletimida, 2-Ethyl-2-(4-pyridyl)glutarimide

CAS 92788-10-8Formula C12H14N2O2Molar mass 218.26 g/mol
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Rogletimide chemical structure, C12H14N2O2, CAS 92788-10-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
92788-10-8
Formula
C12H14N2O2
Molar mass
218.26 g/mol
HS code
293339
Category
Heterocyclic building blocks

What is Rogletimide?

Plain description, key identifiers and synonyms

Rogletimide is an orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a cytochrome P450 family enzyme found in many tissues and the key enzyme in the oxidative aromatization process of androgens to estrogens. In estrogen-dependent cancers, the inhibition of aromatase by this agent leads to a reduction in the synthesis of estrogen, thereby inhibiting estrogen-mediated signal transduction and consequently reducing tumor cell growth. In addition, rogletimide also inhibits enzymes that catalyzing conversion of cholesterol to corticosteroids.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-ethyl-3-pyridin-4-ylpiperidine-2,6-dione
CAS number
92788-10-8 CAS number cross-checkedOther or deprecated CAS: 121840-95-7
Molecular formula
C12H14N2O2
UNII
14P4QR28QF
InChIKey
QXKJWHWUDVQATH-UHFFFAOYSA-N
InChI
InChI=1S/C12H14N2O2/c1-2-12(9-4-7-13-8-5-9)6-3-10(15)14-11(12)16/h4-5,7-8H,2-3,6H2,1H3,(H,14,15,16)
SMILES (canonical and isomeric)
CCC1(CCC(=O)NC1=O)C2=CC=NC=C2

Synonyms

  • Pyridoglutethimide
  • Rogletimida
  • 2-Ethyl-2-(4-pyridyl)glutarimide
  • 2,6-Piperidinedione, 3-ethyl-3-(4-pyridinyl)-
  • 3-Ethyl-3-(4-pyridyl)piperidine-2,6-dione
  • Rogletimidum
  • 3-ethyl-3-pyridin-4-ylpiperidine-2,6-dione
  • 3-ethyl-3-(pyridin-4-yl)piperidine-2,6-dione
  • Pyridoglutethimide, Racemic pyridoglutethimide
  • (+-)-Pyridoglutethimide
  • Racemic-pyridoglutethimide
  • Rogletimide (USAN/INN)
  • 3-ethyl-3-(4-pyridinyl)-2,6-piperidinedione
  • 3-Ethyl-4,5-dihydro-3H-[3,4'']bipyridinyl-2,6-dione
  • (+/-)-Pyridoglutethimide
  • 3-ethyl-3-(4-pyridyl)-2,6-piperidinedione
  • (+/-)-2-Ethyl-2-(4-pyridyl)glutarimide
  • 2,6-Piperidinedione, 3-ethyl-3-(4-pyridinyl)-, (+/-)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
218.26 g/molcalc.
Exact mass
218.1055 Dacalc.
LogP (octanol/water)
1.17calc.
Topological polar surface area
59.06 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC(c2ccncc2)C(=O)N1

O=C1CCC(c2ccncc2)C(=O)N1

2 rings, 14 atoms, the 3-(4-Pyridyl)piperidine-2,6-dione ring system.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Rogletimide suppliers

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Rogletimide price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rogletimide is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Rogletimide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rogletimide, based on the data on this page

What is Rogletimide?

Rogletimide is an orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a cytochrome P450 family enzyme found in many tissues and the key enzyme in the oxidative aromatization process of androgens to estrogens.

What is the CAS number of Rogletimide?

The CAS registry number of Rogletimide is 92788-10-8. Other or deprecated CAS numbers: 121840-95-7.

What is the molecular formula and weight of Rogletimide?

The molecular formula of Rogletimide is C12H14N2O2 and its molar mass is 218.26 g/mol.

What is Rogletimide used for?

Known uses and roles of Rogletimide include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Rogletimide hazardous?

No GHS hazard classification for Rogletimide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Rogletimide?

Rogletimide is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rogletimide?

Post a free request on CompoundList and suppliers of Rogletimide will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Rogletimide?

Suppliers quote Rogletimide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Rogletimide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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