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Heterocyclic building blocks

Senna

Also known as Dosaflex, Gentlax, Sennalax

CAS 8013-11-4Formula C42H38O20Molar mass 862.75 g/molEC 201-339-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 27 suppliers listed
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Senna chemical structure, C42H38O20, CAS 8013-11-4
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Powder
Melting point
200 °C
Solubility
Less than 1 mg/mL at 66 °F
HS code
293299
Category
Heterocyclic building blocks
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Senna?

Plain description, key identifiers and synonyms

Sennoside A is a member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S. It is an oxo dicarboxylic acid and a member of sennosides.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
CAS number
8013-11-4Other or deprecated CAS: 81-27-6
EC numbers
201-339-9, 687-679-2
Molecular formula
C42H38O20
UNII
2F1O30GVXH
MDL number
MFCD00151527
InChIKey
IPQVTOJGNYVQEO-KGFNBKMBSA-N
InChI
InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
Canonical SMILES
O=C(O)c1cc(O)c2c(c1)C(C1c3cc(C(=O)O)cc(O)c3C(=O)c3c(OC4OC(CO)C(O)C(O)C4O)cccc31)c1cccc(OC3OC(CO)C(O)C(O)C3O)c1C2=O
Isomeric SMILES
C1=CC2=C(C(=C1)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=O)C4=C([C@@H]2[C@@H]5C6=C(C(=CC=C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O

Synonyms

  • Dosaflex
  • Gentlax
  • Sennalax
  • Senolax
  • Black Draught
  • Sennoside A
  • Senokot
  • Moivat
  • Sennosides sennoside a
  • Sennoside a (constituent of senna leaf and pods)
  • [9,9'-Bianthracene]-2,2'-dicarboxylic acid,5,5'-bis(b-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (R*,R*)-
  • Glaxenna
  • Exprep
  • Senan
  • Tisasen A
  • Sennoside A, G
  • 4,4',10,10'-Tetrahydroxy-5,5'-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[9,9'-bianthracene]-2,2'-dicarboxylic acid
  • Sennoside A (Standard)
  • Sennosides A + B 99%
  • NIOSH/VT6020000
  • ACon0_001464
  • (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(
  • (-)-(9R*,9'R*)-5,5'-bis(beta-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid
  • (9,9'-Bianthracene)-2,2'-dicarboxylic acid, 5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'r)-
  • (9R*,9'R*)-5,5'-bis(beta-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid
Show all 29 synonyms
  • (9R,9'R)-5,5'-bis(beta-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid
  • (9R,9'R)-5,5'-Bis(beta-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro[9,9'-bianthracene]-2,2'-dicarboxylic acid
  • (9R,9R)-5,5-Bis(beta-d-glucopyranosyloxy)-9,9,10,10-tetrahydro-4,4-dihydroxy-10,10-dioxo(9,9-bianthracene)-2,2-dicarboxylic acid
  • (R*,r*)-5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo(9,9'-bianthracene)-2,2'-dicarboxylic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Powderexp.
Melting point
200 °Cexp.
Solubility
Less than 1 mg/mL at 66 °Fexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
862.75 g/molcalc.
Exact mass
862.1956 Dacalc.
LogP (octanol/water)
-1.1calc.
Topological polar surface area
348 Ųcalc.
Hydrogen bond donors
12calc.
Hydrogen bond acceptors
18calc.
Rotatable bonds
9calc.
Heavy atoms
62calc.
Rings
8calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
12calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1c2ccccc2C(C2c3ccccc3C(=O)c3c(OC4CCCCO4)cccc32)c2cccc(OC3CCCCO3)c21

O=C1c2ccccc2C(C2c3ccccc3C(=O)c3c(OC4CCCCO4)cccc32)c2cccc(OC3CCCCO3)c21

8 rings, 44 atoms.

19 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary statements (19)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Senna suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 27 suppliers
27 of 27 offers
  • Indo German Alkaloids
    India, Mumbai ManufacturerUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
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  • Hefei Reachever Import and Export Co., Ltd
    China, Hefei ManufacturerUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
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  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
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  • Accela ChemBio Inc.
    United States, San DiegoUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
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  • Achemtek
    United States, WoburnUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
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  • Acorn PharmaTech, LLC
    United States, Redwood CityUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
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  • ACTIVATE SCIENTIFIC GmbH
    GermanyUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
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  • AHH Chemical co.,ltd
    China, ChangzhouUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
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  • AiFChem
    United States, SomervilleUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
    View
  • Ambeed, Inc.
    United States, Buffalo GroveUnclaimed profile
    SennaGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

27 suppliers in 5 countries

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Senna price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacology

Senokot is a standardized, concentrated preparation, by Purdue, containing the anthraquinone glycosides sennosides extracted from senna leaves with laxative activity. Sennosides act on and irritate the lining of the intestine wall, thereby causing increased intestinal muscle contractions leading to vigorous bowel movement.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Senna is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Senna is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Senna, based on the data on this page

What is Senna?

Sennoside A is a member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'.

What is the CAS number of Senna?

The CAS registry number of Senna is 8013-11-4. Other or deprecated CAS numbers: 81-27-6.

What is the molecular formula and weight of Senna?

The molecular formula of Senna is C42H38O20 and its molar mass is 862.75 g/mol.

What is Senna used for?

Known uses and roles of Senna include building blocks in research and laboratory.

Is Senna hazardous?

Senna carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Senna?

Senna is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Senna?

CompoundList lists 27 suppliers of Senna in China, United States, Germany, India and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Senna in India?

2 suppliers in India list Senna on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Senna?

Suppliers quote Senna on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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