CompoundList
Sign in
Screening compounds

Tolrestat

Also known as Alredase, Tolrestatum, AY-27,773

CAS 82964-04-3Formula C16H14F3NO3SMolar mass 357.35 g/mol
5 suppliers listed
Get quotes Compare 5 suppliers
Tolrestat chemical structure, C16H14F3NO3S, CAS 82964-04-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
82964-04-3
Formula
C16H14F3NO3S
Molar mass
357.35 g/mol
HS code
293090
Category
Screening compounds

What is Tolrestat?

Plain description, key identifiers and synonyms

Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid
CAS number
82964-04-3 CAS number cross-checked
Molecular formula
C16H14F3NO3S
UNII
0T93LG5NMK
InChIKey
LUBHDINQXIHVLS-UHFFFAOYSA-N
InChI
InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
SMILES (canonical and isomeric)
CN(CC(=O)O)C(=S)C1=CC=CC2=C1C=CC(=C2C(F)(F)F)OC

Synonyms

  • Alredase
  • Tolrestatum
  • AY-27,773
  • 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid
  • N-(6-Methoxythio-5-(trifluoromethyl)-1-naphthoyl)sarcosine
  • N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]carbonothioyl}-N-methylglycine
  • Glycine, N-((6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)thioxomethyl)-N-methyl-
  • N-((5-(trifluoromethyl)-6-methoxy-1-naphthalenyl)thioxomethyl)-N-methylglycine
  • N-[6-Methoxythio-5-(trifluoromethyl)-1-naphthoyl]sarcosine
  • Alderase
  • 2-((6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl)-methylamino)acetic acid
  • Glycine, N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-
  • N-((6-methoxy-5-(trifluoromethyl)naphthalen-1-yl)carbonothioyl)-N-methylglycine
  • N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine
  • N-5-trifluoromethyl-6-methoxy-1-thionaphthoyl-N-methylglycine
  • Lorestat
  • Tolrestatin
  • N-(6-methoxy-5-(trifluoromethyl)naphthalene-1-carbonothioyl)-N-methylglycine
  • n-[[6-methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-n-methylglyeine
  • 2-{1-[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-N-methylmethanethioamido}acetic acid
  • AY 27773
  • N-{[6-methoxy-5-(trifluoromethyl)-1-naphthyl]carbonothioyl}-N-methylglycine
  • N-((6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)thioxomethyl)-N-methylglycine
  • N-[[6-Methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine
  • TOL
Show all 30 synonyms
  • Alrestin
  • Tolrestat?
  • Alredase (TN)
  • Tolrestat (Standard)
  • Tolrestat (USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
357.35 g/molcalc.
Exact mass
357.0646 Dacalc.
LogP (octanol/water)
3.56calc.
Topological polar surface area
49.77 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2ccccc2c1

c1ccc2ccccc2c1

2 rings, 10 atoms, the Naphthalene ring system.

17,920 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Tolrestat suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers
5 of 5 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

5 suppliers in 2 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Tolrestat price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Enzyme Inhibitors

Roles

  • enzyme inhibitor
  • hypoglycemic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tolrestat is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Tolrestat is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tolrestat, based on the data on this page

What is Tolrestat?

Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor.

What is the CAS number of Tolrestat?

The CAS registry number of Tolrestat is 82964-04-3.

What is the molecular formula and weight of Tolrestat?

The molecular formula of Tolrestat is C16H14F3NO3S and its molar mass is 357.35 g/mol.

What is Tolrestat used for?

Known uses and roles of Tolrestat include building blocks in research and laboratory, screening compounds in research and laboratory, biochemical and pharmacological tools in research and laboratory, enzyme inhibitor, hypoglycemic agent and 2 more.

Is Tolrestat hazardous?

No GHS hazard classification for Tolrestat is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Tolrestat?

Tolrestat is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tolrestat?

CompoundList lists 5 suppliers of Tolrestat in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tolrestat?

Suppliers quote Tolrestat on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tolrestat

Get quotes for Tolrestat

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Tolrestat
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Tolrestat with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/tolrestat-82964-04-3" title="Tolrestat structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Screening compounds or HS code 293090

5 suppliers
Free quotes, contact stays private
Get quotes