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Murcko scaffold

Ring system with 4 rings and 22 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
16
With full pages
2
Scaffold SMILES

C(=Cc1ccc(-c2ccccc2)o1)c1nc2ccccc2[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1ccc(-c2ccccc2)o1)c1nc2ccccc2[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

2-(1H-Benzimidazol-2-yl)-3-[5-(2,5-dichlorophenyl)furan-2-yl]prop-2-enenitrile chemical structure, C20H11Cl2N3O, CAS 302552-89-2
2-(1H-Benzimidazol-2-yl)-3-[5-(2,5-dichlorophenyl)furan-2-yl]prop-2-enenitrile
CAS 302552-89-2C20H11Cl2N3O
Methyl 5-[5-[2-(1H-benzimidazol-2-yl)-2-cyanoethenyl]-2-furanyl]-2-chlorobenzoate chemical structure, C22H14ClN3O3, CAS 353785-09-8
Methyl 5-[5-[2-(1H-benzimidazol-2-yl)-2-cyanoethenyl]-2-furanyl]-2-chlorobenzoate
CAS 353785-09-8C22H14ClN3O3
2-(1H-Benzimidazol-2-yl)-3-[5-(5-chloro-2-methoxyphenyl)furan-2-yl]prop-2-enenitrile chemical structure, C21H14ClN3O2, CAS 332064-63-8
2-(1H-Benzimidazol-2-yl)-3-[5-(5-chloro-2-methoxyphenyl)furan-2-yl]prop-2-enenitrile
CAS 332064-63-8C21H14ClN3O2
3-[5-(2,5-Dichlorophenyl)furan-2-yl]-2-(6-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile chemical structure, C21H13Cl2N3O, CAS 5346-28-1
3-[5-(2,5-Dichlorophenyl)furan-2-yl]-2-(6-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile
CAS 5346-28-1C21H13Cl2N3O
2-(1H-Benzimidazol-2-yl)-3-[5-(2,3-dichlorophenyl)-2-furyl]acrylonitrile chemical structure, C20H11Cl2N3O, CAS 332401-10-2
2-(1H-Benzimidazol-2-yl)-3-[5-(2,3-dichlorophenyl)-2-furyl]acrylonitrile
CAS 332401-10-2C20H11Cl2N3O
RefChem:314113 chemical structure, C22H14ClN3O3, CAS 5883-37-4
RefChem:314113
CAS 5883-37-4C22H14ClN3O3
N-[4-[5-[(Z)-2-Cyano-2-(6-methyl-1H-benzimidazol-2-yl)ethenyl]furan-2-yl]phenyl]sulfonylacetamide chemical structure, C23H18N4O4S, CAS 679814-46-1
N-[4-[5-[(Z)-2-Cyano-2-(6-methyl-1H-benzimidazol-2-yl)ethenyl]furan-2-yl]phenyl]sulfonylacetamide
CAS 679814-46-1C23H18N4O4S
3-{5-[(Z)-2-(1H-Benzimidazol-2-yl)-2-cyanoethenyl]furan-2-yl}-4-methylbenzoic acid chemical structure, C22H15N3O3, CAS 663205-01-4
3-{5-[(Z)-2-(1H-Benzimidazol-2-yl)-2-cyanoethenyl]furan-2-yl}-4-methylbenzoic acid
CAS 663205-01-4C22H15N3O3
Ethyl 3-{5-[(E)-2-cyano-2-(6-methyl-1H-benzimidazol-2-yl)ethenyl]furan-2-yl}benzoate chemical structure, C24H19N3O3, CAS 694500-99-7
Ethyl 3-{5-[(E)-2-cyano-2-(6-methyl-1H-benzimidazol-2-yl)ethenyl]furan-2-yl}benzoate
CAS 694500-99-7C24H19N3O3
(E)-2-(1H-Benzimidazol-2-yl)-3-[5-(4-chlorophenyl)furan-2-yl]prop-2-enenitrile chemical structure, C20H12ClN3O, CAS 300675-12-1
(E)-2-(1H-Benzimidazol-2-yl)-3-[5-(4-chlorophenyl)furan-2-yl]prop-2-enenitrile
CAS 300675-12-1C20H12ClN3O
(E)-3-(5-(4-Bromophenyl)furan-2-yl)-2-(1-methyl-1H-benzo[d]imidazol-2-yl)acrylonitrile chemical structure, C21H14BrN3O, CAS 300773-01-7
(E)-3-(5-(4-Bromophenyl)furan-2-yl)-2-(1-methyl-1H-benzo[d]imidazol-2-yl)acrylonitrile
CAS 300773-01-7C21H14BrN3O
(2E)-3-[5-(4-Acetylphenyl)furan-2-yl]-2-(1-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile chemical structure, C23H17N3O2, CAS 865593-44-8
(2E)-3-[5-(4-Acetylphenyl)furan-2-yl]-2-(1-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile
CAS 865593-44-8C23H17N3O2
(E)-4-(5-(2-Cyano-2-(1-methyl-1H-benzo[d]imidazol-2-yl)vinyl)furan-2-yl)benzenesulfonamide chemical structure, C21H16N4O3S, CAS 1164507-35-0
(E)-4-(5-(2-Cyano-2-(1-methyl-1H-benzo[d]imidazol-2-yl)vinyl)furan-2-yl)benzenesulfonamide
CAS 1164507-35-0C21H16N4O3S
(Z)-2-(1H-Benzimidazol-2-yl)-3-[5-(2-chloro-5-nitrophenyl)furan-2-yl]prop-2-enenitrile chemical structure, C20H11ClN4O3, CAS 328971-58-0
(Z)-2-(1H-Benzimidazol-2-yl)-3-[5-(2-chloro-5-nitrophenyl)furan-2-yl]prop-2-enenitrile
CAS 328971-58-0C20H11ClN4O3
(Z)-2-(1H-Benzo[d]imidazol-2-yl)-3-(5-(3-chloro-4-fluorophenyl)furan-2-yl)acrylonitrile chemical structure, C20H11ClFN3O, CAS 369634-26-4
(Z)-2-(1H-Benzo[d]imidazol-2-yl)-3-(5-(3-chloro-4-fluorophenyl)furan-2-yl)acrylonitrile
CAS 369634-26-4C20H11ClFN3O
2-(1H-Benzimidazol-2-yl)-3-(5-(4-bromophenyl)-2-furyl)acrylonitrile chemical structure, C20H12BrN3O, CAS 302552-88-1
2-(1H-Benzimidazol-2-yl)-3-(5-(4-bromophenyl)-2-furyl)acrylonitrile
CAS 302552-88-1C20H12BrN3O