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Murcko scaffold

Ring system with 4 rings and 22 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
14
With full pages
2
Scaffold SMILES

c1ccc(-c2nnc(SCc3nc4ccccc4[nH]3)[nH]2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2nnc(SCc3nc4ccccc4[nH]3)[nH]2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

2-[(5-Phenyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1H-benzimidazole chemical structure, C19H17N5S, CAS 412959-45-6
2-[(5-Phenyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1H-benzimidazole
CAS 412959-45-6C19H17N5S
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(3-methylphenyl)-4H-1,2,4-triazol-4-amine chemical structure, C17H16N6S, CAS 676590-15-1
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(3-methylphenyl)-4H-1,2,4-triazol-4-amine
CAS 676590-15-1C17H16N6S
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(2-methylphenyl)-4H-1,2,4-triazol-4-amine chemical structure, C17H16N6S, CAS 573929-63-2
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(2-methylphenyl)-4H-1,2,4-triazol-4-amine
CAS 573929-63-2C17H16N6S
3-(1H-Benzimidazol-2-ylmethylsulfanyl)-5-(3-methoxyphenyl)-1,2,4-triazol-4-amine chemical structure, C17H16N6OS, CAS 587009-03-8
3-(1H-Benzimidazol-2-ylmethylsulfanyl)-5-(3-methoxyphenyl)-1,2,4-triazol-4-amine
CAS 587009-03-8C17H16N6OS
2-[[5-(3-Chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1H-benzimidazole chemical structure, C18H16ClN5S, CAS 710983-08-7
2-[[5-(3-Chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1H-benzimidazole
CAS 710983-08-7C18H16ClN5S
2-[[5-(3-Methylphenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1H-benzimidazole chemical structure, C20H19N5S, CAS 710984-85-3
2-[[5-(3-Methylphenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1H-benzimidazole
CAS 710984-85-3C20H19N5S
3-(1H-Benzimidazol-2-ylmethylsulfanyl)-5-(3-bromophenyl)-1,2,4-triazol-4-amine chemical structure, C16H13BrN6S, CAS 378773-83-2
3-(1H-Benzimidazol-2-ylmethylsulfanyl)-5-(3-bromophenyl)-1,2,4-triazol-4-amine
CAS 378773-83-2C16H13BrN6S
N-[3-[5-(1H-Benzimidazol-2-ylmethylsulfanyl)-4-methyl-1,2,4-triazol-3-yl]phenyl]propanamide chemical structure, C20H20N6OS, CAS 500265-01-0
N-[3-[5-(1H-Benzimidazol-2-ylmethylsulfanyl)-4-methyl-1,2,4-triazol-3-yl]phenyl]propanamide
CAS 500265-01-0C20H20N6OS
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(2-chlorophenyl)-4H-1,2,4-triazol-4-amine chemical structure, C16H13ClN6S, CAS 152562-59-9
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(2-chlorophenyl)-4H-1,2,4-triazol-4-amine
CAS 152562-59-9C16H13ClN6S
3-(1H-Benzoimidazol-2-ylmethylsulfanyl)-5-(4-ethoxy-phenyl)-[1,2,4]triazol-4-ylamine chemical structure, C18H18N6OS, CAS 578697-48-0
3-(1H-Benzoimidazol-2-ylmethylsulfanyl)-5-(4-ethoxy-phenyl)-[1,2,4]triazol-4-ylamine
CAS 578697-48-0C18H18N6OS
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(3-ethoxyphenyl)-4H-1,2,4-triazol-4-amine chemical structure, C18H18N6OS, CAS 678189-72-5
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(3-ethoxyphenyl)-4H-1,2,4-triazol-4-amine
CAS 678189-72-5C18H18N6OS
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(2-fluorophenyl)-4H-1,2,4-triazol-4-amine chemical structure, C16H13FN6S, CAS 577982-22-0
3-[(1H-Benzimidazol-2-ylmethyl)sulfanyl]-5-(2-fluorophenyl)-4H-1,2,4-triazol-4-amine
CAS 577982-22-0C16H13FN6S
4H-1,2,4-Triazol-4-amine, 3-[(1H-benzimidazol-2-ylmethyl)thio]-5-(4-chlorophenyl)- chemical structure, C16H13ClN6S, CAS 116859-52-0
4H-1,2,4-Triazol-4-amine, 3-[(1H-benzimidazol-2-ylmethyl)thio]-5-(4-chlorophenyl)-
CAS 116859-52-0C16H13ClN6S
3-{[(1H-1,3-Benzodiazol-2-yl)methyl]sulfanyl}-5-(2,4-dichlorophenyl)-4H-1,2,4-triazol-4-amine chemical structure, C16H12Cl2N6S, CAS 880803-81-6
3-{[(1H-1,3-Benzodiazol-2-yl)methyl]sulfanyl}-5-(2,4-dichlorophenyl)-4H-1,2,4-triazol-4-amine
CAS 880803-81-6C16H12Cl2N6S