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Murcko scaffold

Ring system with 4 rings and 24 atoms

28 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
28
With full pages
6
Scaffold SMILES

O=C(Nc1nc2ccccc2s1)C1CC(=O)N(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nc2ccccc2s1)C1CC(=O)N(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

N-(1,3-Benzothiazol-2-yl)-1-(3-chloro-4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16ClN3O2S, CAS 346598-88-7
N-(1,3-Benzothiazol-2-yl)-1-(3-chloro-4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 346598-88-7C19H16ClN3O2S
N-(1,3-Benzothiazol-2-yl)-1-(4-ethoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H19N3O3S, CAS 309734-01-8
N-(1,3-Benzothiazol-2-yl)-1-(4-ethoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 309734-01-8C20H19N3O3S
N-(1,3-Benzothiazol-2-yl)-1-(2,3-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H19N3O2S, CAS 499111-33-0
N-(1,3-Benzothiazol-2-yl)-1-(2,3-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 499111-33-0C20H19N3O2S
N-(1,3-Benzothiazol-2-yl)-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H17N3O3S, CAS 496940-39-7
N-(1,3-Benzothiazol-2-yl)-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 496940-39-7C19H17N3O3S
N-(6-Methoxy-1,3-benzothiazol-2-yl)-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H19N3O3S, CAS 825597-81-7
N-(6-Methoxy-1,3-benzothiazol-2-yl)-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 825597-81-7C20H19N3O3S
1-(4-Methylphenyl)-N-(6-methylsulfonyl-1,3-benzothiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H19N3O4S2, CAS 781617-99-0
1-(4-Methylphenyl)-N-(6-methylsulfonyl-1,3-benzothiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 781617-99-0C20H19N3O4S2
N-(1,3-Benzothiazol-2-yl)-1-(3-nitrophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H14N4O4S, CAS 364383-83-5
N-(1,3-Benzothiazol-2-yl)-1-(3-nitrophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 364383-83-5C18H14N4O4S
N-(6-Methoxy-1,3-benzothiazol-2-yl)-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C19H17N3O3S, CAS 839693-42-4
N-(6-Methoxy-1,3-benzothiazol-2-yl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
CAS 839693-42-4C19H17N3O3S
1-(4-Methoxyphenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H19N3O5S2, CAS 878726-14-8
1-(4-Methoxyphenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide
CAS 878726-14-8C20H19N3O5S2
1-(4-Fluorophenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16FN3O4S2, CAS 878731-07-8
1-(4-Fluorophenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide
CAS 878731-07-8C19H16FN3O4S2
N-[6-(Methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxo-1-phenyl-3-pyrrolidinecarboxamide chemical structure, C19H17N3O4S2, CAS 887673-12-3
N-[6-(Methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxo-1-phenyl-3-pyrrolidinecarboxamide
CAS 887673-12-3C19H17N3O4S2
1-(4-Chlorophenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16ClN3O4S2, CAS 879601-55-5
1-(4-Chlorophenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide
CAS 879601-55-5C19H16ClN3O4S2
N-(6-Ethoxy-1,3-benzothiazol-2-yl)-5-oxo-1-phenyl-3-pyrrolidinecarboxamide chemical structure, C20H19N3O3S, CAS 847568-73-4
N-(6-Ethoxy-1,3-benzothiazol-2-yl)-5-oxo-1-phenyl-3-pyrrolidinecarboxamide
CAS 847568-73-4C20H19N3O3S
1-(3,4-Dimethylphenyl)-N-(6-methoxy-1,3-benzothiazol-2-yl)-5-oxo-3-pyrrolidinecarboxamide chemical structure, C21H21N3O3S, CAS 847568-72-3
1-(3,4-Dimethylphenyl)-N-(6-methoxy-1,3-benzothiazol-2-yl)-5-oxo-3-pyrrolidinecarboxamide
CAS 847568-72-3C21H21N3O3S
1-(3,4-Dimethylphenyl)-N-(6-methyl-1,3-benzothiazol-2-yl)-5-oxo-3-pyrrolidinecarboxamide chemical structure, C21H21N3O2S, CAS 847568-71-2
1-(3,4-Dimethylphenyl)-N-(6-methyl-1,3-benzothiazol-2-yl)-5-oxo-3-pyrrolidinecarboxamide
CAS 847568-71-2C21H21N3O2S
N-(1,3-Benzothiazol-2-yl)-1-(2,4-dimethoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H19N3O4S, CAS 924980-30-3
N-(1,3-Benzothiazol-2-yl)-1-(2,4-dimethoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 924980-30-3C20H19N3O4S
1-(3-Methoxyphenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H19N3O5S2, CAS 924965-49-1
1-(3-Methoxyphenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide
CAS 924965-49-1C20H19N3O5S2
1-(2-Methoxyphenyl)-N-[(2E)-6-(methylsulfonyl)-1,3-benzothiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H19N3O5S2, CAS 1007693-96-0
1-(2-Methoxyphenyl)-N-[(2E)-6-(methylsulfonyl)-1,3-benzothiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide
CAS 1007693-96-0C20H19N3O5S2
N-[(2E)-1,3-Benzothiazol-2(3H)-ylidene]-1-(3-chloro-4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16ClN3O3S, CAS 1007694-04-3
N-[(2E)-1,3-Benzothiazol-2(3H)-ylidene]-1-(3-chloro-4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 1007694-04-3C19H16ClN3O3S
1-(2-Chlorophenyl)-N-[(2Z)-6-(methylsulfonyl)-1,3-benzothiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16ClN3O4S2, CAS 1012527-44-4
1-(2-Chlorophenyl)-N-[(2Z)-6-(methylsulfonyl)-1,3-benzothiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide
CAS 1012527-44-4C19H16ClN3O4S2
1-(2-Fluorophenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16FN3O4S2, CAS 1016468-64-6
1-(2-Fluorophenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide
CAS 1016468-64-6C19H16FN3O4S2
N-(1,3-Benzothiazol-2-yl)-1-(3-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H17N3O3S, CAS 1009256-61-4
N-(1,3-Benzothiazol-2-yl)-1-(3-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 1009256-61-4C19H17N3O3S
1-(3-Chlorophenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16ClN3O4S2, CAS 914228-78-7
1-(3-Chlorophenyl)-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-5-oxopyrrolidine-3-carboxamide
CAS 914228-78-7C19H16ClN3O4S2
N-[(2Z)-1,3-Benzothiazol-2(3H)-ylidene]-1-(2-fluorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H14FN3O2S, CAS 1144466-74-9
N-[(2Z)-1,3-Benzothiazol-2(3H)-ylidene]-1-(2-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 1144466-74-9C18H14FN3O2S