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Murcko scaffold

Ring system with 3 rings and 18 atoms

35 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
35
With full pages
19
Scaffold SMILES

O=C1NC(=O)c2cc(Oc3ccccc3)ccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=O)c2cc(Oc3ccccc3)ccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

2-(2-Hydroxyethyl)-5-(4-nitrophenoxy)isoindole-1,3-dione chemical structure, C16H12N2O6, CAS 294667-10-0
2-(2-Hydroxyethyl)-5-(4-nitrophenoxy)isoindole-1,3-dione
CAS 294667-10-0C16H12N2O6
5-(3-Aminophenoxy)-2-(2-hydroxyethyl)isoindole-1,3-dione chemical structure, C16H14N2O4, CAS 442653-55-6
5-(3-Aminophenoxy)-2-(2-hydroxyethyl)isoindole-1,3-dione
CAS 442653-55-6C16H14N2O4
5-(4-Aminophenoxy)-2-(2-hydroxyethyl)-1H-isoindole-1,3(2H)-dione chemical structure, C16H14N2O4, CAS 434299-34-0
5-(4-Aminophenoxy)-2-(2-hydroxyethyl)-1H-isoindole-1,3(2H)-dione
CAS 434299-34-0C16H14N2O4
N-[5-(4-Nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]acetamide chemical structure, C16H11N3O6, CAS 312274-89-8
N-[5-(4-Nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]acetamide
CAS 312274-89-8C16H11N3O6
[5-(2-Methoxyphenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]acetic acid chemical structure, C17H13NO6, CAS 431909-67-0
[5-(2-Methoxyphenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]acetic acid
CAS 431909-67-0C17H13NO6
[5-(4-Methylphenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]acetic acid chemical structure, C17H13NO5, CAS 650596-15-9
[5-(4-Methylphenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]acetic acid
CAS 650596-15-9C17H13NO5
2-(2-Methylpropyl)-5-(4-nitrophenoxy)isoindole-1,3-dione chemical structure, C18H16N2O5, CAS 294890-78-1
2-(2-Methylpropyl)-5-(4-nitrophenoxy)isoindole-1,3-dione
CAS 294890-78-1C18H16N2O5
2-tert-Butyl-5-(4-nitrophenoxy)isoindole-1,3-dione chemical structure, C18H16N2O5, CAS 667403-79-4
2-tert-Butyl-5-(4-nitrophenoxy)isoindole-1,3-dione
CAS 667403-79-4C18H16N2O5
2-tert-Butyl-5-(3-nitrophenoxy)isoindole-1,3-dione chemical structure, C18H16N2O5, CAS 774184-10-0
2-tert-Butyl-5-(3-nitrophenoxy)isoindole-1,3-dione
CAS 774184-10-0C18H16N2O5
2-Methyl-5-phenoxyisoindole-1,3-dione chemical structure, C15H11NO3, CAS 63197-24-0
2-Methyl-5-phenoxyisoindole-1,3-dione
CAS 63197-24-0C15H11NO3
5-(4-Nitrophenoxy)-1H-isoindole-1,3(2H)-dione chemical structure, C14H8N2O5, CAS 284462-38-0
5-(4-Nitrophenoxy)-1H-isoindole-1,3(2H)-dione
CAS 284462-38-0C14H8N2O5
2-[5-(3-Nitrophenoxy)-1,3-dioxoisoindol-2-yl]acetic acid chemical structure, C16H10N2O7, CAS 351979-54-9
2-[5-(3-Nitrophenoxy)-1,3-dioxoisoindol-2-yl]acetic acid
CAS 351979-54-9C16H10N2O7
2-[5-(4-Nitrophenoxy)-1,3-dioxoisoindol-2-yl]acetic acid chemical structure, C16H10N2O7, CAS 351979-62-9
2-[5-(4-Nitrophenoxy)-1,3-dioxoisoindol-2-yl]acetic acid
CAS 351979-62-9C16H10N2O7
5-(4-Aminophenoxy)isoindoline-1,3-dione chemical structure, C14H10N2O3, CAS 284462-39-1
5-(4-Aminophenoxy)isoindoline-1,3-dione
CAS 284462-39-1C14H10N2O3
5-(3-Aminophenoxy)-1H-isoindole-1,3(2H)-dione chemical structure, C14H10N2O3, CAS 404361-65-5
5-(3-Aminophenoxy)-1H-isoindole-1,3(2H)-dione
CAS 404361-65-5C14H10N2O3
2-Methyl-5-(4-nitrophenoxy)isoindole-1,3-dione chemical structure, C15H10N2O5, CAS 284462-48-2
2-Methyl-5-(4-nitrophenoxy)isoindole-1,3-dione
CAS 284462-48-2C15H10N2O5
N-[4-(1,3-Dioxoisoindol-5-yl)oxyphenyl]butanamide chemical structure, C18H16N2O4, CAS 690981-11-4
N-[4-(1,3-Dioxoisoindol-5-yl)oxyphenyl]butanamide
CAS 690981-11-4C18H16N2O4
N-{4-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-5-yl)oxy]phenyl}-2-methylpropanamide chemical structure, C18H16N2O4, CAS 500263-62-7
N-{4-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-5-yl)oxy]phenyl}-2-methylpropanamide
CAS 500263-62-7C18H16N2O4
N-[3-(1,3-Dioxoisoindol-5-yl)oxyphenyl]acetamide chemical structure, C16H12N2O4, CAS 693795-41-4
N-[3-(1,3-Dioxoisoindol-5-yl)oxyphenyl]acetamide
CAS 693795-41-4C16H12N2O4
N-{4-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-5-yl)oxy]phenyl}propanamide chemical structure, C17H14N2O4, CAS 667410-92-6
N-{4-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-5-yl)oxy]phenyl}propanamide
CAS 667410-92-6C17H14N2O4
N-[4-(1,3-Dioxoisoindol-5-yl)oxyphenyl]-3-methylbutanamide chemical structure, C19H18N2O4, CAS 701253-82-9
N-[4-(1,3-Dioxoisoindol-5-yl)oxyphenyl]-3-methylbutanamide
CAS 701253-82-9C19H18N2O4
N-[3-(1,3-Dioxoisoindol-5-yl)oxyphenyl]butanamide chemical structure, C18H16N2O4, CAS 701259-81-6
N-[3-(1,3-Dioxoisoindol-5-yl)oxyphenyl]butanamide
CAS 701259-81-6C18H16N2O4
4-[5-(3-Nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]butanoic acid chemical structure, C18H14N2O7, CAS 709006-59-7
4-[5-(3-Nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]butanoic acid
CAS 709006-59-7C18H14N2O7
3-[5-(4-Nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]propanoic acid chemical structure, C17H12N2O7, CAS 294891-64-8
3-[5-(4-Nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]propanoic acid
CAS 294891-64-8C17H12N2O7