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Murcko scaffold

1-Piperonylpiperazine scaffold

77 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
77
With full pages
14
Scaffold SMILES

c1cc2c(cc1CN1CCNCC1)OCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Piperonylpiperazine page
Murcko scaffold c1cc2c(cc1CN1CCNCC1)OCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 77 chemicals

1-Piperonylpiperazine chemical structure, C12H16N2O2, CAS 32231-06-4
1-Piperonylpiperazine
CAS 32231-06-4C12H16N2O2
1-(3,4-Methylenedioxybenzyl)-4-(1-oxobutyl)piperazine chemical structure, C16H22N2O3, CAS 163130-28-7
1-(3,4-Methylenedioxybenzyl)-4-(1-oxobutyl)piperazine
CAS 163130-28-7C16H22N2O3
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-3-methylbutan-1-one chemical structure, C17H24N2O3, CAS 332160-67-5
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-3-methylbutan-1-one
CAS 332160-67-5C17H24N2O3
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2,2-dimethylpropan-1-one chemical structure, C17H24N2O3, CAS 505088-50-6
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2,2-dimethylpropan-1-one
CAS 505088-50-6C17H24N2O3
1-(1,3-Benzodioxol-5-ylmethyl)-4-propan-2-ylpiperazine chemical structure, C15H22N2O2, CAS 428504-96-5
1-(1,3-Benzodioxol-5-ylmethyl)-4-propan-2-ylpiperazine
CAS 428504-96-5C15H22N2O2
Piperazine, 1-methyl-4-(3,4-methylenedioxybenzyl)- chemical structure, C13H18N2O2, CAS 55500-12-4
Piperazine, 1-methyl-4-(3,4-methylenedioxybenzyl)-
CAS 55500-12-4C13H18N2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(ethylsulfonyl)piperazine chemical structure, C14H20N2O4S, CAS 428853-29-6
1-(1,3-Benzodioxol-5-ylmethyl)-4-(ethylsulfonyl)piperazine
CAS 428853-29-6C14H20N2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-propylsulfonylpiperazine chemical structure, C15H22N2O4S, CAS 428844-47-7
1-(1,3-Benzodioxol-5-ylmethyl)-4-propylsulfonylpiperazine
CAS 428844-47-7C15H22N2O4S
4-(1,3-Benzodioxol-5-ylmethyl)-N-ethylpiperazine-1-carbothioamide chemical structure, C15H21N3O2S, CAS 351332-12-2
4-(1,3-Benzodioxol-5-ylmethyl)-N-ethylpiperazine-1-carbothioamide
CAS 351332-12-2C15H21N3O2S
1-(1,3-Benzodioxol-5-ylmethyl)-4-methylsulfonylpiperazine chemical structure, C13H18N2O4S, CAS 349626-05-7
1-(1,3-Benzodioxol-5-ylmethyl)-4-methylsulfonylpiperazine
CAS 349626-05-7C13H18N2O4S
4-(Benzo[d][1,3]dioxol-5-ylmethyl)-N-methylpiperazine-1-carbothioamide chemical structure, C14H19N3O2S, CAS 351332-37-1
4-(Benzo[d][1,3]dioxol-5-ylmethyl)-N-methylpiperazine-1-carbothioamide
CAS 351332-37-1C14H19N3O2S
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-3-oxopropanenitrile chemical structure, C15H17N3O3, CAS 546116-57-8
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-3-oxopropanenitrile
CAS 546116-57-8C15H17N3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazino]-2-methylpropanenitrile chemical structure, C16H21N3O2, CAS 338753-88-1
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazino]-2-methylpropanenitrile
CAS 338753-88-1C16H21N3O2
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]propanenitrile chemical structure, C15H19N3O2, CAS 385371-21-1
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]propanenitrile
CAS 385371-21-1C15H19N3O2
Ethyl 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-oxoacetate chemical structure, C16H20N2O5, CAS 349442-66-6
Ethyl 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-oxoacetate
CAS 349442-66-6C16H20N2O5
4-(1,3-Benzodioxol-5-ylmethyl)-N-(2-methoxyethyl)piperazine-1-carbothioamide chemical structure, C16H23N3O3S, CAS 708280-81-3
4-(1,3-Benzodioxol-5-ylmethyl)-N-(2-methoxyethyl)piperazine-1-carbothioamide
CAS 708280-81-3C16H23N3O3S
4-(1,3-Benzodioxol-5-ylmethyl)-N,N-dimethylpiperazine-1-carboxamide chemical structure, C15H21N3O3, CAS 717853-04-8
4-(1,3-Benzodioxol-5-ylmethyl)-N,N-dimethylpiperazine-1-carboxamide
CAS 717853-04-8C15H21N3O3
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazino]-1,1,1-trifluoro-2-propanol chemical structure, C15H19F3N2O3, CAS 866135-64-0
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazino]-1,1,1-trifluoro-2-propanol
CAS 866135-64-0C15H19F3N2O3
5-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-5-oxopentanoic acid chemical structure, C17H22N2O5, CAS 620931-00-2
5-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-5-oxopentanoic acid
CAS 620931-00-2C17H22N2O5
1-(1,3-Benzodioxol-5-ylmethyl)-4-butan-2-ylpiperazine chemical structure, C16H24N2O2, CAS 428836-21-9
1-(1,3-Benzodioxol-5-ylmethyl)-4-butan-2-ylpiperazine
CAS 428836-21-9C16H24N2O2
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2,2,2-trichloroethanone chemical structure, C14H15Cl3N2O3, CAS 349637-15-6
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2,2,2-trichloroethanone
CAS 349637-15-6C14H15Cl3N2O3
Piperazine, 1-(2-hydroxyethyl)-4-(3,4-methylenedioxybenzyl)- chemical structure, C14H20N2O3, CAS 55436-33-4
Piperazine, 1-(2-hydroxyethyl)-4-(3,4-methylenedioxybenzyl)-
CAS 55436-33-4C14H20N2O3
Piperazine, 1-(3,4-methylenedioxybenzyl)-4-(2-propynyl)- chemical structure, C15H18N2O2, CAS 55436-34-5
Piperazine, 1-(3,4-methylenedioxybenzyl)-4-(2-propynyl)-
CAS 55436-34-5C15H18N2O2
Piperazine, 1-allyl-4-(3,4-methylenedioxybenzyl)- chemical structure, C15H20N2O2, CAS 55436-35-6
Piperazine, 1-allyl-4-(3,4-methylenedioxybenzyl)-
CAS 55436-35-6C15H20N2O2