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Murcko scaffold

Ring system with 3 rings and 17 atoms

11 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
11
With full pages
8
Scaffold SMILES

O=C1c2ccnn2CCN1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1c2ccnn2CCN1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

5-(2-Chlorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid chemical structure, C14H12ClN3O3, CAS 477854-37-8
5-(2-Chlorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid
CAS 477854-37-8C14H12ClN3O3
5-(4-Methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid chemical structure, C15H15N3O4, CAS 477854-40-3
5-(4-Methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid
CAS 477854-40-3C15H15N3O4
Methyl 5-(4-methylbenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C16H17N3O3, CAS 477845-43-5
Methyl 5-(4-methylbenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
CAS 477845-43-5C16H17N3O3
Methyl 5-(2-fluorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C15H14FN3O3, CAS 477845-45-7
Methyl 5-(2-fluorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
CAS 477845-45-7C15H14FN3O3
Methyl 5-(4-fluorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C15H14FN3O3, CAS 477845-46-8
Methyl 5-(4-fluorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
CAS 477845-46-8C15H14FN3O3
Methyl 5-(4-methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C16H17N3O4, CAS 477845-47-9
Methyl 5-(4-methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
CAS 477845-47-9C16H17N3O4
Methyl 5-(2-chlorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C15H14ClN3O3, CAS 477845-48-0
Methyl 5-(2-chlorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
CAS 477845-48-0C15H14ClN3O3
Methyl 5-(3-methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C16H17N3O4, CAS 400074-39-7
Methyl 5-(3-methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
CAS 400074-39-7C16H17N3O4
N-Isopropyl-5-(4-methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide chemical structure, C18H22N4O3, CAS 477859-35-1
N-Isopropyl-5-(4-methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
CAS 477859-35-1C18H22N4O3
Ethyl 5-benzyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C16H17N3O3, CAS 1338563-40-8
Ethyl 5-benzyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
CAS 1338563-40-8C16H17N3O3
2-Bromo-3-chloro-5-[(4-methoxyphenyl)methyl]-7-(trifluoromethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one chemical structure, C15H12BrClF3N3O2, CAS 2766229-95-0
2-Bromo-3-chloro-5-[(4-methoxyphenyl)methyl]-7-(trifluoromethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
CAS 2766229-95-0C15H12BrClF3N3O2