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Murcko scaffold

1H-Pyrazolo(3,4-d)pyrimidin-4-one, 4,5-dihydro-5-benzyl- scaffold

132 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 17
Chemicals: 132
With full pages: 6

Scaffold SMILES

O=c1c2cn[nH]c2ncn1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1H-Pyrazolo(3,4-d)pyrimidin-4-one, 4,5-dihydro-5-benzyl- page

Murcko scaffold O=c1c2cn[nH]c2ncn1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 132 chemicals

5-Benzyl-1,6-dimethylpyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H14N4O, CAS 88320-55-2

5-Benzyl-1,6-dimethylpyrazolo[3,4-d]pyrimidin-4-one

CAS 88320-55-2C₁₄H₁₄N₄O

5-(2-Chlorobenzyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C13H11ClN4O, CAS 866843-48-3

5-(2-Chlorobenzyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

CAS 866843-48-3C₁₃H₁₁ClN₄O

4-Methoxy-3-[(1-methyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)methyl]benzaldehyde chemical structure, C15H14N4O3, CAS 866843-52-9

4-Methoxy-3-[(1-methyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)methyl]benzaldehyde

CAS 866843-52-9C₁₅H₁₄N₄O₃

5-(2-Chloro-6-fluorobenzyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C13H10ClFN4O, CAS 866844-56-6

5-(2-Chloro-6-fluorobenzyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

CAS 866844-56-6C₁₃H₁₀ClFN₄O

2-[(1-Methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]benzonitrile chemical structure, C14H11N5O, CAS 866870-34-0

2-[(1-Methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]benzonitrile

CAS 866870-34-0C₁₄H₁₁N₅O

5-(2-Chloro-4-fluorobenzyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C13H10ClFN4O, CAS 866870-36-2

5-(2-Chloro-4-fluorobenzyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

CAS 866870-36-2C₁₃H₁₀ClFN₄O

5-[(5-Acetyl-2-methoxyphenyl)methyl]-1-methylpyrazolo[3,4-d]pyrimidin-4-one chemical structure, C16H16N4O3, CAS 778622-93-8

5-[(5-Acetyl-2-methoxyphenyl)methyl]-1-methylpyrazolo[3,4-d]pyrimidin-4-one

CAS 778622-93-8C₁₆H₁₆N₄O₃

1H-Pyrazolo(3,4-d)pyrimidin-4-one, 4,5-dihydro-5-benzyl- chemical structure, C12H10N4O, CAS 69398-33-0

1H-Pyrazolo(3,4-d)pyrimidin-4-one, 4,5-dihydro-5-benzyl-

CAS 69398-33-0C₁₂H₁₀N₄O

1-(tert-Butyl)-5-(2,5-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C18H22N4O, CAS 863448-25-3

1-(tert-Butyl)-5-(2,5-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

CAS 863448-25-3C₁₈H₂₂N₄O

1-tert-Butyl-5-(2-chloro-6-fluorobenzyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C16H16ClFN4O, CAS 863448-22-0

1-tert-Butyl-5-(2-chloro-6-fluorobenzyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

CAS 863448-22-0C₁₆H₁₆ClFN₄O

1-tert-Butyl-5-(2,4-dichlorobenzyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C16H16Cl2N4O, CAS 863448-35-5

1-tert-Butyl-5-(2,4-dichlorobenzyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

CAS 863448-35-5C₁₆H₁₆Cl₂N₄O

5-Benzyl-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C16H18N4O, CAS 863448-14-0

5-Benzyl-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

CAS 863448-14-0C₁₆H₁₈N₄O

1-(tert-Butyl)-5-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C17H20N4O, CAS 863448-23-1

1-(tert-Butyl)-5-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

CAS 863448-23-1C₁₇H₂₀N₄O

1-tert-Butyl-5-[(2-chlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C16H17ClN4O, CAS 863448-24-2

1-tert-Butyl-5-[(2-chlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 863448-24-2C₁₆H₁₇ClN₄O

1-(tert-Butyl)-5-(3,4-dichlorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C16H16Cl2N4O, CAS 863448-30-0

1-(tert-Butyl)-5-(3,4-dichlorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

CAS 863448-30-0C₁₆H₁₆Cl₂N₄O

1-(tert-Butyl)-5-(2-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C16H17FN4O, CAS 863448-31-1

1-(tert-Butyl)-5-(2-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

CAS 863448-31-1C₁₆H₁₇FN₄O

5-Benzyl-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H14N4O2, CAS 922919-20-8

5-Benzyl-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 922919-20-8C₁₄H₁₄N₄O₂

1-(2-Hydroxyethyl)-5-[(4-nitrophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H13N5O4, CAS 899742-82-6

1-(2-Hydroxyethyl)-5-[(4-nitrophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 899742-82-6C₁₄H₁₃N₅O₄

5-[(2,5-Dimethylphenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C16H18N4O2, CAS 900011-69-0

5-[(2,5-Dimethylphenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 900011-69-0C₁₆H₁₈N₄O₂

1-(2-Hydroxyethyl)-5-[(3-nitrophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H13N5O4, CAS 900011-72-5

1-(2-Hydroxyethyl)-5-[(3-nitrophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 900011-72-5C₁₄H₁₃N₅O₄

5-[(4-Bromophenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H13BrN4O2, CAS 899756-76-4

5-[(4-Bromophenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 899756-76-4C₁₄H₁₃BrN₄O₂

5-[(4-Chlorophenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H13ClN4O2, CAS 899954-02-0

5-[(4-Chlorophenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 899954-02-0C₁₄H₁₃ClN₄O₂

5-[(2-Chloro-6-fluorophenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H12ClFN4O2, CAS 899995-32-5

5-[(2-Chloro-6-fluorophenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 899995-32-5C₁₄H₁₂ClFN₄O₂

5-[(2-Chlorophenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H13ClN4O2, CAS 899756-78-6

5-[(2-Chlorophenyl)methyl]-1-(2-hydroxyethyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 899756-78-6C₁₄H₁₃ClN₄O₂