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Murcko scaffold

4-Benzoylpiperazin-2-one scaffold

113 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
113
With full pages
16
Scaffold SMILES

O=C1CN(C(=O)c2ccccc2)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Benzoylpiperazin-2-one page
Murcko scaffold O=C1CN(C(=O)c2ccccc2)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 113 chemicals

4-Benzoyl-3-methylpiperazin-2-one chemical structure, C12H14N2O2, CAS 1030374-29-8
4-Benzoyl-3-methylpiperazin-2-one
CAS 1030374-29-8C12H14N2O2
Ethyl 2-[1-(2,6-difluorobenzoyl)-3-oxo-2-piperazinyl]acetate chemical structure, C15H16F2N2O4, CAS 129355-67-5
Ethyl 2-[1-(2,6-difluorobenzoyl)-3-oxo-2-piperazinyl]acetate
CAS 129355-67-5C15H16F2N2O4
4-(2-Aminobenzoyl)-2-piperazinone chemical structure, C11H13N3O2, CAS 671794-74-4
4-(2-Aminobenzoyl)-2-piperazinone
CAS 671794-74-4C11H13N3O2
Methyl 2-(1-(4-nitrobenzoyl)-3-oxopiperazin-2-yl)acetate chemical structure, C14H15N3O6, CAS 474263-09-7
Methyl 2-(1-(4-nitrobenzoyl)-3-oxopiperazin-2-yl)acetate
CAS 474263-09-7C14H15N3O6
Methyl 2-[3-oxo-1-(phenylcarbonyl)piperazin-2-yl]acetate chemical structure, C14H16N2O4, CAS 1008955-24-5
Methyl 2-[3-oxo-1-(phenylcarbonyl)piperazin-2-yl]acetate
CAS 1008955-24-5C14H16N2O4
3-Ethyl-4-(3-iodo-4-methylbenzoyl)piperazin-2-one chemical structure, C14H17IN2O2, CAS 1009240-72-5
3-Ethyl-4-(3-iodo-4-methylbenzoyl)piperazin-2-one
CAS 1009240-72-5C14H17IN2O2
Piperazinone, 4-(3,4,5-trimethoxybenzoyl)- chemical structure, C14H18N2O5, CAS 59701-93-8
Piperazinone, 4-(3,4,5-trimethoxybenzoyl)-
CAS 59701-93-8C14H18N2O5
Methyl 2-[1-(4-fluorobenzoyl)-3-oxopiperazin-2-yl]acetate chemical structure, C14H15FN2O4, CAS 1008954-81-1
Methyl 2-[1-(4-fluorobenzoyl)-3-oxopiperazin-2-yl]acetate
CAS 1008954-81-1C14H15FN2O4
Ethyl 2-{3-oxo-1-[3-(trifluoromethyl)benzoyl]-2-piperazinyl}acetate chemical structure, C16H17F3N2O4, CAS 318469-59-9
Ethyl 2-{3-oxo-1-[3-(trifluoromethyl)benzoyl]-2-piperazinyl}acetate
CAS 318469-59-9C16H17F3N2O4
Ethyl 2-[1-(3-methoxybenzoyl)-3-oxo-2-piperazinyl]acetate chemical structure, C16H20N2O5, CAS 318959-08-9
Ethyl 2-[1-(3-methoxybenzoyl)-3-oxo-2-piperazinyl]acetate
CAS 318959-08-9C16H20N2O5
Ethyl 2-[1-(3,4-dichlorobenzoyl)-3-oxo-2-piperazinyl]acetate chemical structure, C15H16Cl2N2O4, CAS 318469-60-2
Ethyl 2-[1-(3,4-dichlorobenzoyl)-3-oxo-2-piperazinyl]acetate
CAS 318469-60-2C15H16Cl2N2O4
Ethyl 2-[1-(2,6-dichlorobenzoyl)-3-oxo-2-piperazinyl]acetate chemical structure, C15H16Cl2N2O4, CAS 318469-61-3
Ethyl 2-[1-(2,6-dichlorobenzoyl)-3-oxo-2-piperazinyl]acetate
CAS 318469-61-3C15H16Cl2N2O4
Ethyl 2-[1-(2,4-dichlorobenzoyl)-3-oxo-2-piperazinyl]acetate chemical structure, C15H16Cl2N2O4, CAS 318469-62-4
Ethyl 2-[1-(2,4-dichlorobenzoyl)-3-oxo-2-piperazinyl]acetate
CAS 318469-62-4C15H16Cl2N2O4
Ethyl 1-(4-chlorobenzoyl)-3-oxo-2-piperazineacetate chemical structure, C15H17ClN2O4, CAS 318469-63-5
Ethyl 1-(4-chlorobenzoyl)-3-oxo-2-piperazineacetate
CAS 318469-63-5C15H17ClN2O4
Ethyl 2-(1-benzoyl-3-oxopiperazin-2-yl)acetate chemical structure, C15H18N2O4, CAS 318469-64-6
Ethyl 2-(1-benzoyl-3-oxopiperazin-2-yl)acetate
CAS 318469-64-6C15H18N2O4
Ethyl 2-[1-(4-methylbenzoyl)-3-oxo-2-piperazinyl]acetate chemical structure, C16H20N2O4, CAS 318288-60-7
Ethyl 2-[1-(4-methylbenzoyl)-3-oxo-2-piperazinyl]acetate
CAS 318288-60-7C16H20N2O4
Ethyl 2-[1-(2,4-difluorobenzoyl)-3-oxo-2-piperazinyl]acetate chemical structure, C15H16F2N2O4, CAS 318288-62-9
Ethyl 2-[1-(2,4-difluorobenzoyl)-3-oxo-2-piperazinyl]acetate
CAS 318288-62-9C15H16F2N2O4
Methyl 2-[1-(2-chloro-5-nitrobenzoyl)-3-oxopiperazin-2-yl]acetate chemical structure, C14H14ClN3O6, CAS 1008016-23-6
Methyl 2-[1-(2-chloro-5-nitrobenzoyl)-3-oxopiperazin-2-yl]acetate
CAS 1008016-23-6C14H14ClN3O6
Methyl 1-(3,5-dichlorobenzoyl)-3-oxo-2-piperazineacetate chemical structure, C14H14Cl2N2O4, CAS 1008945-27-4
Methyl 1-(3,5-dichlorobenzoyl)-3-oxo-2-piperazineacetate
CAS 1008945-27-4C14H14Cl2N2O4
Propan-2-yl 2-[1-(4-butoxybenzoyl)-3-oxopiperazin-2-yl]acetate chemical structure, C20H28N2O5, CAS 1009172-14-8
Propan-2-yl 2-[1-(4-butoxybenzoyl)-3-oxopiperazin-2-yl]acetate
CAS 1009172-14-8C20H28N2O5
Propan-2-yl 2-[3-oxo-1-(2-propoxybenzoyl)piperazin-2-yl]acetate chemical structure, C19H26N2O5, CAS 1008226-93-4
Propan-2-yl 2-[3-oxo-1-(2-propoxybenzoyl)piperazin-2-yl]acetate
CAS 1008226-93-4C19H26N2O5
4-(3-Nitrobenzoyl)piperazin-2-one chemical structure, C11H11N3O4, CAS 160822-43-5
4-(3-Nitrobenzoyl)piperazin-2-one
CAS 160822-43-5C11H11N3O4
4-(3-Chlorobenzoyl)piperazin-2-one chemical structure, C11H11ClN2O2, CAS 160822-41-3
4-(3-Chlorobenzoyl)piperazin-2-one
CAS 160822-41-3C11H11ClN2O2
4-Benzoylpiperazin-2-one chemical structure, C11H12N2O2, CAS 13754-42-2
4-Benzoylpiperazin-2-one
CAS 13754-42-2C11H12N2O2