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Murcko scaffold

4-Benzoylpiperazin-2-one scaffold

113 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
113
With full pages
16
Scaffold SMILES

O=C1CN(C(=O)c2ccccc2)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Benzoylpiperazin-2-one page
Murcko scaffold O=C1CN(C(=O)c2ccccc2)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 113 of 113 chemicals

4-(3-Bromo-4-methylbenzoyl)piperazin-2-one chemical structure, C12H13BrN2O2, CAS 1512447-86-7
4-(3-Bromo-4-methylbenzoyl)piperazin-2-one
CAS 1512447-86-7C12H13BrN2O2
4-(2,3,4-Trifluorobenzoyl)piperazin-2-one chemical structure, C11H9F3N2O2, CAS 1520543-09-2
4-(2,3,4-Trifluorobenzoyl)piperazin-2-one
CAS 1520543-09-2C11H9F3N2O2
4-(2-Bromo-5-methylbenzoyl)piperazin-2-one chemical structure, C12H13BrN2O2, CAS 1538889-38-1
4-(2-Bromo-5-methylbenzoyl)piperazin-2-one
CAS 1538889-38-1C12H13BrN2O2
4-(2-Bromo-4-methylbenzoyl)piperazin-2-one chemical structure, C12H13BrN2O2, CAS 1557311-29-1
4-(2-Bromo-4-methylbenzoyl)piperazin-2-one
CAS 1557311-29-1C12H13BrN2O2
4-(2-Bromo-3-methylbenzoyl)piperazin-2-one chemical structure, C12H13BrN2O2, CAS 1920711-34-7
4-(2-Bromo-3-methylbenzoyl)piperazin-2-one
CAS 1920711-34-7C12H13BrN2O2
4-(4-Hydrazinyl-2-methylbenzoyl)piperazin-2-one chemical structure, C12H16N4O2, CAS 1566463-96-4
4-(4-Hydrazinyl-2-methylbenzoyl)piperazin-2-one
CAS 1566463-96-4C12H16N4O2
4-(3-Fluoro-5-methylbenzoyl)piperazin-2-one chemical structure, C12H13FN2O2, CAS 1710631-12-1
4-(3-Fluoro-5-methylbenzoyl)piperazin-2-one
CAS 1710631-12-1C12H13FN2O2
4-(3-Bromo-5-methylbenzoyl)piperazin-2-one chemical structure, C12H13BrN2O2, CAS 1983397-49-4
4-(3-Bromo-5-methylbenzoyl)piperazin-2-one
CAS 1983397-49-4C12H13BrN2O2
4-(3-Aminobenzoyl)-3-methylpiperazin-2-one hydrochloride chemical structure, C12H16ClN3O2, CAS 1835958-34-3
4-(3-Aminobenzoyl)-3-methylpiperazin-2-one hydrochloride
CAS 1835958-34-3C12H16ClN3O2
N-[[4-(4-Ethyl-3-oxopiperazine-1-carbonyl)phenyl]methyl]prop-2-enamide chemical structure, C17H21N3O3, CAS 2201498-51-1
N-[[4-(4-Ethyl-3-oxopiperazine-1-carbonyl)phenyl]methyl]prop-2-enamide
CAS 2201498-51-1C17H21N3O3
N-[[4-(2-Methyl-3-oxo-2-propylpiperazine-1-carbonyl)phenyl]methyl]prop-2-enamide chemical structure, C19H25N3O3, CAS 2200205-70-3
N-[[4-(2-Methyl-3-oxo-2-propylpiperazine-1-carbonyl)phenyl]methyl]prop-2-enamide
CAS 2200205-70-3C19H25N3O3
4-[3-(Trifluoromethoxy)benzoyl]piperazin-2-one chemical structure, C12H11F3N2O3, CAS 2327218-25-5
4-[3-(Trifluoromethoxy)benzoyl]piperazin-2-one
CAS 2327218-25-5C12H11F3N2O3
4-(3-Chloro-5-fluorobenzoyl)piperazin-2-one chemical structure, C11H10ClFN2O2, CAS 2329286-22-6
4-(3-Chloro-5-fluorobenzoyl)piperazin-2-one
CAS 2329286-22-6C11H10ClFN2O2
N-[4-(3,4-Dimethyl-5-oxopiperazine-1-carbonyl)phenyl]prop-2-enamide chemical structure, C16H19N3O3, CAS 2411274-09-2
N-[4-(3,4-Dimethyl-5-oxopiperazine-1-carbonyl)phenyl]prop-2-enamide
CAS 2411274-09-2C16H19N3O3
4-(2-Chloro-4-methoxybenzoyl)piperazin-2-one chemical structure, C12H13ClN2O3, CAS 2948821-78-9
4-(2-Chloro-4-methoxybenzoyl)piperazin-2-one
CAS 2948821-78-9C12H13ClN2O3
4-(4-Chloro-2,3-difluorobenzoyl)-1-methylpiperazin-2-one chemical structure, C12H11ClF2N2O2, CAS 2450052-33-0
4-(4-Chloro-2,3-difluorobenzoyl)-1-methylpiperazin-2-one
CAS 2450052-33-0C12H11ClF2N2O2
4-(2-Chloro-5-fluorobenzoyl)piperazin-2-one chemical structure, C11H10ClFN2O2, CAS 2948274-52-8
4-(2-Chloro-5-fluorobenzoyl)piperazin-2-one
CAS 2948274-52-8C11H10ClFN2O2