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Murcko scaffold

4-Benzoylpiperazin-2-one scaffold

113 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
113
With full pages
16
Scaffold SMILES

O=C1CN(C(=O)c2ccccc2)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Benzoylpiperazin-2-one page
Murcko scaffold O=C1CN(C(=O)c2ccccc2)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 113 chemicals

Dodecyl 1-(3-bromo-4-methylbenzoyl)-3-oxo-2-piperazineacetate chemical structure, C26H39BrN2O4, CAS 1166990-90-4
Dodecyl 1-(3-bromo-4-methylbenzoyl)-3-oxo-2-piperazineacetate
CAS 1166990-90-4C26H39BrN2O4
Dodecyl 1-[4-(1,1-dimethylethyl)benzoyl]-3-oxo-2-piperazineacetate chemical structure, C29H46N2O4, CAS 1166062-39-0
Dodecyl 1-[4-(1,1-dimethylethyl)benzoyl]-3-oxo-2-piperazineacetate
CAS 1166062-39-0C29H46N2O4
2-Piperazinone, 4-(2,5-dimethoxybenzoyl)- chemical structure, C13H16N2O4, CAS 950005-16-0
2-Piperazinone, 4-(2,5-dimethoxybenzoyl)-
CAS 950005-16-0C13H16N2O4
4-(4-Bromobenzoyl)piperazin-2-one chemical structure, C11H11BrN2O2, CAS 917562-11-9
4-(4-Bromobenzoyl)piperazin-2-one
CAS 917562-11-9C11H11BrN2O2
4-(2-Bromobenzoyl)piperazin-2-one chemical structure, C11H11BrN2O2, CAS 1016891-24-9
4-(2-Bromobenzoyl)piperazin-2-one
CAS 1016891-24-9C11H11BrN2O2
4-(3-Oxopiperazine-1-carbonyl)benzonitrile chemical structure, C12H11N3O2, CAS 1017054-96-4
4-(3-Oxopiperazine-1-carbonyl)benzonitrile
CAS 1017054-96-4C12H11N3O2
4-(2-Bromo-4-fluorobenzoyl)piperazin-2-one chemical structure, C11H10BrFN2O2, CAS 1017056-69-7
4-(2-Bromo-4-fluorobenzoyl)piperazin-2-one
CAS 1017056-69-7C11H10BrFN2O2
(3R)-4-(4-Fluorobenzoyl)-3-methyl-2-piperazinone chemical structure, C12H13FN2O2, CAS 1892599-91-5
(3R)-4-(4-Fluorobenzoyl)-3-methyl-2-piperazinone
CAS 1892599-91-5C12H13FN2O2
4-(2-Chloro-4-fluorobenzoyl)piperazin-2-one chemical structure, C11H10ClFN2O2, CAS 1030164-97-6
4-(2-Chloro-4-fluorobenzoyl)piperazin-2-one
CAS 1030164-97-6C11H10ClFN2O2
4-(5-Chloro-2-methoxybenzoyl)piperazin-2-one chemical structure, C12H13ClN2O3, CAS 1088193-05-8
4-(5-Chloro-2-methoxybenzoyl)piperazin-2-one
CAS 1088193-05-8C12H13ClN2O3
4-(5-Bromo-2-chlorobenzoyl)piperazin-2-one chemical structure, C11H10BrClN2O2, CAS 1031176-97-2
4-(5-Bromo-2-chlorobenzoyl)piperazin-2-one
CAS 1031176-97-2C11H10BrClN2O2
4-(4-Iodobenzoyl)piperazin-2-one chemical structure, C11H11IN2O2, CAS 1031632-95-7
4-(4-Iodobenzoyl)piperazin-2-one
CAS 1031632-95-7C11H11IN2O2
4-(4-Nitrobenzoyl)piperazin-2-one chemical structure, C11H11N3O4, CAS 718621-52-4
4-(4-Nitrobenzoyl)piperazin-2-one
CAS 718621-52-4C11H11N3O4
4-(2-Hydroxy-4-methoxybenzoyl)piperazin-2-one chemical structure, C12H14N2O4, CAS 1019444-27-9
4-(2-Hydroxy-4-methoxybenzoyl)piperazin-2-one
CAS 1019444-27-9C12H14N2O4
4-(3,5-Difluorobenzoyl)piperazin-2-one chemical structure, C11H10F2N2O2, CAS 1455775-37-7
4-(3,5-Difluorobenzoyl)piperazin-2-one
CAS 1455775-37-7C11H10F2N2O2
4-(2-Fluorobenzoyl)piperazin-2-one chemical structure, C11H11FN2O2, CAS 1178747-11-9
4-(2-Fluorobenzoyl)piperazin-2-one
CAS 1178747-11-9C11H11FN2O2
4-(3,4-Dichlorobenzoyl)piperazin-2-one chemical structure, C11H10Cl2N2O2, CAS 1254073-47-6
4-(3,4-Dichlorobenzoyl)piperazin-2-one
CAS 1254073-47-6C11H10Cl2N2O2
4-(2,3-Dichlorobenzoyl)piperazin-2-one chemical structure, C11H10Cl2N2O2, CAS 1146411-63-3
4-(2,3-Dichlorobenzoyl)piperazin-2-one
CAS 1146411-63-3C11H10Cl2N2O2
4-(2,5-Dichlorobenzoyl)piperazin-2-one chemical structure, C11H10Cl2N2O2, CAS 1458218-50-2
4-(2,5-Dichlorobenzoyl)piperazin-2-one
CAS 1458218-50-2C11H10Cl2N2O2
4-(3,5-Dichlorobenzoyl)piperazin-2-one chemical structure, C11H10Cl2N2O2, CAS 1282894-99-8
4-(3,5-Dichlorobenzoyl)piperazin-2-one
CAS 1282894-99-8C11H10Cl2N2O2
4-(3-Fluorobenzoyl)piperazin-2-one chemical structure, C11H11FN2O2, CAS 1240843-04-2
4-(3-Fluorobenzoyl)piperazin-2-one
CAS 1240843-04-2C11H11FN2O2
4-(2,4-Difluorobenzoyl)piperazin-2-one chemical structure, C11H10F2N2O2, CAS 1254073-29-4
4-(2,4-Difluorobenzoyl)piperazin-2-one
CAS 1254073-29-4C11H10F2N2O2
4-(2,4-Dimethylbenzoyl)piperazin-2-one chemical structure, C13H16N2O2, CAS 1197809-88-3
4-(2,4-Dimethylbenzoyl)piperazin-2-one
CAS 1197809-88-3C13H16N2O2
4-[2-(Trifluoromethyl)benzoyl]piperazin-2-one chemical structure, C12H11F3N2O2, CAS 1147288-79-6
4-[2-(Trifluoromethyl)benzoyl]piperazin-2-one
CAS 1147288-79-6C12H11F3N2O2