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Murcko scaffold

Ring system with 4 rings and 25 atoms

70 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
70
With full pages
30
Scaffold SMILES

c1ccc(CSc2nnc(-c3ccncc3)n2-c2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CSc2nnc(-c3ccncc3)n2-c2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 70 chemicals

4-[4-(4-Ethoxyphenyl)-5-[(2-fluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine chemical structure, C22H19FN4OS, CAS 663213-40-9
4-[4-(4-Ethoxyphenyl)-5-[(2-fluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine
CAS 663213-40-9C22H19FN4OS
4-[4-(4-Fluorophenyl)-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine chemical structure, C21H17FN4S, CAS 663213-30-7
4-[4-(4-Fluorophenyl)-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine
CAS 663213-30-7C21H17FN4S
4-(5-{[(4-Fluorophenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine chemical structure, C20H15FN4S, CAS 663214-22-0
4-(5-{[(4-Fluorophenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine
CAS 663214-22-0C20H15FN4S
4-[5-[(4-Chlorophenyl)methylsulfanyl]-4-(3,4-dimethylphenyl)-1,2,4-triazol-3-yl]pyridine chemical structure, C22H19ClN4S, CAS 663213-37-4
4-[5-[(4-Chlorophenyl)methylsulfanyl]-4-(3,4-dimethylphenyl)-1,2,4-triazol-3-yl]pyridine
CAS 663213-37-4C22H19ClN4S
4-(5-{[(4-Methylphenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine chemical structure, C21H18N4S, CAS 482636-75-9
4-(5-{[(4-Methylphenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine
CAS 482636-75-9C21H18N4S
4-[5-[(4-Chlorophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazol-3-yl]pyridine chemical structure, C20H15ClN4S, CAS 482636-76-0
4-[5-[(4-Chlorophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazol-3-yl]pyridine
CAS 482636-76-0C20H15ClN4S
4-[5-(Benzylsulfanyl)-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]pyridine chemical structure, C21H18N4S, CAS 482637-19-4
4-[5-(Benzylsulfanyl)-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]pyridine
CAS 482637-19-4C21H18N4S
4-(4-Methylphenyl)-3-[(4-methylphenyl)methylthio]-5-(4-pyridyl)-1,2,4-triazole chemical structure, C22H20N4S, CAS 443741-44-4
4-(4-Methylphenyl)-3-[(4-methylphenyl)methylthio]-5-(4-pyridyl)-1,2,4-triazole
CAS 443741-44-4C22H20N4S
4-{5-[(2-Chlorobenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl}pyridine chemical structure, C21H17ClN4S, CAS 443741-46-6
4-{5-[(2-Chlorobenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl}pyridine
CAS 443741-46-6C21H17ClN4S
4-{5-[(2-Chloro-6-fluorobenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl}pyridine chemical structure, C21H16ClFN4S, CAS 443741-50-2
4-{5-[(2-Chloro-6-fluorobenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl}pyridine
CAS 443741-50-2C21H16ClFN4S
4-(4-(4-Bromophenyl)-5-((2-fluorobenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine chemical structure, C20H14BrFN4S, CAS 477332-68-6
4-(4-(4-Bromophenyl)-5-((2-fluorobenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine
CAS 477332-68-6C20H14BrFN4S
4-[4-(4-Chlorophenyl)-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine chemical structure, C21H17ClN4OS, CAS 680601-04-1
4-[4-(4-Chlorophenyl)-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine
CAS 680601-04-1C21H17ClN4OS
3-[(2-Fluorophenyl)methylthio]-4-(4-methylphenyl)-5-(4-pyridyl)-1,2,4-triazole chemical structure, C21H17FN4S, CAS 499124-46-8
3-[(2-Fluorophenyl)methylthio]-4-(4-methylphenyl)-5-(4-pyridyl)-1,2,4-triazole
CAS 499124-46-8C21H17FN4S
4-{5-[(4-Fluorobenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl}pyridine chemical structure, C21H17FN4S, CAS 499124-47-9
4-{5-[(4-Fluorobenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl}pyridine
CAS 499124-47-9C21H17FN4S
3-[(3-Fluorophenyl)methylthio]-4-(4-methylphenyl)-5-(4-pyridyl)-1,2,4-triazole chemical structure, C21H17FN4S, CAS 499124-49-1
3-[(3-Fluorophenyl)methylthio]-4-(4-methylphenyl)-5-(4-pyridyl)-1,2,4-triazole
CAS 499124-49-1C21H17FN4S
4-(4-Methylphenyl)-3-[(2-methylphenyl)methylthio]-5-(4-pyridyl)-1,2,4-triazole chemical structure, C22H20N4S, CAS 499124-50-4
4-(4-Methylphenyl)-3-[(2-methylphenyl)methylthio]-5-(4-pyridyl)-1,2,4-triazole
CAS 499124-50-4C22H20N4S
4-[4-(4-Methylphenyl)-5-{[3-(trifluoromethyl)benzyl]sulfanyl}-4H-1,2,4-triazol-3-yl]pyridine chemical structure, C22H17F3N4S, CAS 499124-84-4
4-[4-(4-Methylphenyl)-5-{[3-(trifluoromethyl)benzyl]sulfanyl}-4H-1,2,4-triazol-3-yl]pyridine
CAS 499124-84-4C22H17F3N4S
4-[5-[(3-Bromophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazol-3-yl]pyridine chemical structure, C20H15BrN4S, CAS 701227-44-3
4-[5-[(3-Bromophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazol-3-yl]pyridine
CAS 701227-44-3C20H15BrN4S
4-{5-[(4-Bromobenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl}pyridine chemical structure, C21H17BrN4S, CAS 499124-78-6
4-{5-[(4-Bromobenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl}pyridine
CAS 499124-78-6C21H17BrN4S
4-[5-[(3-Methoxyphenyl)methylsulfanyl]-4-(4-methylphenyl)-1,2,4-triazol-3-yl]pyridine chemical structure, C22H20N4OS, CAS 499124-51-5
4-[5-[(3-Methoxyphenyl)methylsulfanyl]-4-(4-methylphenyl)-1,2,4-triazol-3-yl]pyridine
CAS 499124-51-5C22H20N4OS
4-(((4-(4-BR-Phenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)ME)benzonitrile chemical structure, C21H14BrN5S, CAS 477333-08-7
4-(((4-(4-BR-Phenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)ME)benzonitrile
CAS 477333-08-7C21H14BrN5S
4-(4-(4-Bromophenyl)-5-((3-methylbenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine chemical structure, C21H17BrN4S, CAS 477330-90-8
4-(4-(4-Bromophenyl)-5-((3-methylbenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine
CAS 477330-90-8C21H17BrN4S
4-(5-{[(4-Nitrophenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine chemical structure, C20H15N5O2S, CAS 6009-29-6
4-(5-{[(4-Nitrophenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine
CAS 6009-29-6C20H15N5O2S
4-{4-(4-Chlorophenyl)-5-[(3-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}pyridine chemical structure, C20H14ClFN4S, CAS 498546-20-6
4-{4-(4-Chlorophenyl)-5-[(3-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}pyridine
CAS 498546-20-6C20H14ClFN4S