Murcko scaffold
Ring system with 4 rings and 25 atoms
114 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 114
- With full pages
- 28
Scaffold SMILES
c1ccc(CSc2nnc(-c3ccccc3)n2-c2ccccc2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 114 chemicals
![3-(3-Fluoro-benzylsulfanyl)-5-(3-fluoro-phenyl)-4-phenyl-4H-[1,2,4]triazole chemical structure, C21H15F2N3S, CAS 426235-74-7](/s/WDPOHKGAZVMAME-UHFFFAOYSA-N.svg)
3-(3-Fluoro-benzylsulfanyl)-5-(3-fluoro-phenyl)-4-phenyl-4H-[1,2,4]triazole
CAS 426235-74-7C21H15F2N3S
![3-[(2-Chlorophenyl)methylsulfanyl]-5-(3-fluorophenyl)-4-phenyl-1,2,4-triazole chemical structure, C21H15ClFN3S, CAS 329921-75-7](/s/CIHRPCVURJWQGF-UHFFFAOYSA-N.svg)
3-[(2-Chlorophenyl)methylsulfanyl]-5-(3-fluorophenyl)-4-phenyl-1,2,4-triazole
CAS 329921-75-7C21H15ClFN3S
![3-[(2-Methoxyphenyl)methylsulfanyl]-4,5-diphenyl-1,2,4-triazole chemical structure, C22H19N3OS, CAS 632298-90-9](/s/YTPSOSMDBGKMGF-UHFFFAOYSA-N.svg)
3-[(2-Methoxyphenyl)methylsulfanyl]-4,5-diphenyl-1,2,4-triazole
CAS 632298-90-9C22H19N3OS
4-(5-((4-Chlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)phenol
CAS 444153-38-2C21H16ClN3OS
![3-[(4-Methoxyphenyl)methylsulfanyl]-4,5-diphenyl-1,2,4-triazole chemical structure, C22H19N3OS, CAS 339012-87-2](/s/YKXNMKLQVYSFAY-UHFFFAOYSA-N.svg)
3-[(4-Methoxyphenyl)methylsulfanyl]-4,5-diphenyl-1,2,4-triazole
CAS 339012-87-2C22H19N3OS
4,5-Diphenyl-4H-1,2,4-triazol-3-yl 4-fluorobenzyl sulfide
CAS 452949-88-1C21H16FN3S
![Methyl 4-({[5-(3-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzoate chemical structure, C24H21N3O3S, CAS 457954-85-7](/s/YDQHBHQNFKBAPO-UHFFFAOYSA-N.svg)
Methyl 4-({[5-(3-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzoate
CAS 457954-85-7C24H21N3O3S
![3-(3,4-Dimethoxyphenyl)-5-[(4-methoxybenzyl)sulfanyl]-4-phenyl-4H-1,2,4-triazole chemical structure, C24H23N3O3S, CAS 311786-92-2](/s/YDWCDJWXNRWYIP-UHFFFAOYSA-N.svg)
3-(3,4-Dimethoxyphenyl)-5-[(4-methoxybenzyl)sulfanyl]-4-phenyl-4H-1,2,4-triazole
CAS 311786-92-2C24H23N3O3S
![4-({[5-(2-Fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzonitrile chemical structure, C22H15FN4S, CAS 712283-81-3](/s/SSHGOQITPBBEJA-UHFFFAOYSA-N.svg)
4-({[5-(2-Fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzonitrile
CAS 712283-81-3C22H15FN4S
![3-(3-Fluorophenyl)-5-[(3-nitrobenzyl)sulfanyl]-4-phenyl-4H-1,2,4-triazole chemical structure, C21H15FN4O2S, CAS 442630-22-0](/s/WSYLDKGMLDVWMJ-UHFFFAOYSA-N.svg)
3-(3-Fluorophenyl)-5-[(3-nitrobenzyl)sulfanyl]-4-phenyl-4H-1,2,4-triazole
CAS 442630-22-0C21H15FN4O2S
![3-(4-Methoxyphenyl)-5-[(2-nitrophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole chemical structure, C22H18N4O3S, CAS 329921-76-8](/s/AUCQLVCPXMHDRP-UHFFFAOYSA-N.svg)
3-(4-Methoxyphenyl)-5-[(2-nitrophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole
CAS 329921-76-8C22H18N4O3S
![3-(4-Methoxyphenyl)-5-[(4-nitrophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole chemical structure, C22H18N4O3S, CAS 329921-81-5](/s/VZQUJSZIPOGLAO-UHFFFAOYSA-N.svg)
3-(4-Methoxyphenyl)-5-[(4-nitrophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole
CAS 329921-81-5C22H18N4O3S
![3-[(4-Fluorophenyl)methylsulfanyl]-5-(4-methoxyphenyl)-4-phenyl-1,2,4-triazole chemical structure, C22H18FN3OS, CAS 329921-84-8](/s/VKDBPXDELMFJJX-UHFFFAOYSA-N.svg)
3-[(4-Fluorophenyl)methylsulfanyl]-5-(4-methoxyphenyl)-4-phenyl-1,2,4-triazole
CAS 329921-84-8C22H18FN3OS
![3-[5-[(4-Chlorophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazol-3-yl]aniline chemical structure, C21H17ClN4S, CAS 701229-80-3](/s/VZRMYUMAQZVFPU-UHFFFAOYSA-N.svg)
3-[5-[(4-Chlorophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazol-3-yl]aniline
CAS 701229-80-3C21H17ClN4S
![3-[(4-Fluorophenyl)methylsulfanyl]-5-(4-nitrophenyl)-4-phenyl-1,2,4-triazole chemical structure, C21H15FN4O2S, CAS 353287-75-9](/s/IJHRVOZZWJRQPG-UHFFFAOYSA-N.svg)
3-[(4-Fluorophenyl)methylsulfanyl]-5-(4-nitrophenyl)-4-phenyl-1,2,4-triazole
CAS 353287-75-9C21H15FN4O2S
![3-[(2-Fluorophenyl)methylsulfanyl]-5-(4-nitrophenyl)-4-phenyl-1,2,4-triazole chemical structure, C21H15FN4O2S, CAS 693234-60-5](/s/PFHFESCRTORQLN-UHFFFAOYSA-N.svg)
3-[(2-Fluorophenyl)methylsulfanyl]-5-(4-nitrophenyl)-4-phenyl-1,2,4-triazole
CAS 693234-60-5C21H15FN4O2S
![2-[(4,5-Diphenyl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile chemical structure, C22H16N4S, CAS 693236-41-8](/s/ZAXMSSNKFIRNRL-UHFFFAOYSA-N.svg)
2-[(4,5-Diphenyl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile
CAS 693236-41-8C22H16N4S
![Methyl 3-[[5-(4-methoxyphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate chemical structure, C24H21N3O3S, CAS 442873-43-0](/s/SHKIUFUZNMXLAC-UHFFFAOYSA-N.svg)
Methyl 3-[[5-(4-methoxyphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate
CAS 442873-43-0C24H21N3O3S
![3-(3-Methoxyphenyl)-5-[(4-methoxyphenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole chemical structure, C23H21N3O2S, CAS 341936-64-9](/s/PCXWJULOFPFUGB-UHFFFAOYSA-N.svg)
3-(3-Methoxyphenyl)-5-[(4-methoxyphenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole
CAS 341936-64-9C23H21N3O2S
![3-(3,4-Dimethoxyphenyl)-5-[(4-fluorophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole chemical structure, C23H20FN3O2S, CAS 311784-01-7](/s/XGAWGZUFGZIIET-UHFFFAOYSA-N.svg)
3-(3,4-Dimethoxyphenyl)-5-[(4-fluorophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole
CAS 311784-01-7C23H20FN3O2S
![3-[(4-Nitrophenyl)methylsulfanyl]-4-phenyl-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazole chemical structure, C24H22N4O5S, CAS 327093-49-2](/s/JBMRFFIVGRIILJ-UHFFFAOYSA-N.svg)
3-[(4-Nitrophenyl)methylsulfanyl]-4-phenyl-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazole
CAS 327093-49-2C24H22N4O5S
![4-[(4,5-Diphenyl-1,2,4-triazol-3-yl)sulfanylmethyl]benzoic acid chemical structure, C22H17N3O2S, CAS 348593-21-5](/s/DOHGOFAURHEKQT-UHFFFAOYSA-N.svg)
4-[(4,5-Diphenyl-1,2,4-triazol-3-yl)sulfanylmethyl]benzoic acid
CAS 348593-21-5C22H17N3O2S
![3-[(4-tert-Butylbenzyl)sulfanyl]-5-(4-tert-butylphenyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazole chemical structure, C30H35N3OS, CAS 499103-28-5](/s/UKSUVJWVNCMLGL-UHFFFAOYSA-N.svg)
3-[(4-tert-Butylbenzyl)sulfanyl]-5-(4-tert-butylphenyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazole
CAS 499103-28-5C30H35N3OS
![3-(4-tert-Butylphenyl)-4-(4-methoxyphenyl)-5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazole chemical structure, C27H29N3OS, CAS 499103-22-9](/s/JNGAAEFONWYISJ-UHFFFAOYSA-N.svg)
3-(4-tert-Butylphenyl)-4-(4-methoxyphenyl)-5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazole
CAS 499103-22-9C27H29N3OS
- 3-(4-tert-Butylphenyl)-4-(4-methoxyphenyl)-5-[(3-methylbenzyl)sulfanyl]-4H-1,2,4-triazole499103-39-8C27H29N3OS
- 3-(Benzylsulfanyl)-5-(4-chlorophenyl)-4-(4-methylphenyl)-4H-1,2,4-triazole41401-20-1C22H18ClN3S
- 3-(4-CL-PH)-5-((2,5-Dimethylbenzyl)thio)-4-(4-methylphenyl)-4H-1,2,4-triazole477330-28-2C24H22ClN3S
- 3-(4-Chlorophenyl)-4-(4-methylphenyl)-5-{[3-(trifluoromethyl)benzyl]sulfanyl}-4H-1,2,4-triazole477330-96-4C23H17ClF3N3S
- 3-(4-tert-Butylphenyl)-5-[(3,4-dichlorobenzyl)sulfanyl]-4-(4-methoxyphenyl)-4H-1,2,4-triazole499103-21-8C26H25Cl2N3OS
- 3-(4-tert-Butylphenyl)-5-[(2-chloro-6-fluorobenzyl)sulfanyl]-4-(4-methoxyphenyl)-4H-1,2,4-triazole499103-34-3C26H25ClFN3OS
- 3-(4-Chlorophenyl)-5-((3-methylbenzyl)thio)-4-(4-methylphenyl)-4H-1,2,4-triazole477332-65-3C23H20ClN3S
- 4-(4-Chlorophenyl)-3-[(3-fluorobenzyl)sulfanyl]-5-(4-methoxyphenyl)-4H-1,2,4-triazole498547-05-0C22H17ClFN3OS
- 3-(4-tert-Butylphenyl)-5-[(2-fluorobenzyl)sulfanyl]-4-(4-methoxyphenyl)-4H-1,2,4-triazole499102-96-4C26H26FN3OS
- 3-((2-Chlorobenzyl)thio)-5-(4-chlorophenyl)-4-(4-methylphenyl)-4H-1,2,4-triazole443738-33-8C22H17Cl2N3S
- 3-(4-Chlorophenyl)-5-[(3-methoxybenzyl)sulfanyl]-4-(4-methylphenyl)-4H-1,2,4-triazole499102-19-1C23H20ClN3OS
- 3-(4-CL-PH)-5-((2,4-Dichlorobenzyl)thio)-4-(4-methylphenyl)-4H-1,2,4-triazole443740-26-9C22H16Cl3N3S
- 3-(4-tert-Butylphenyl)-5-[(2,5-dimethylbenzyl)sulfanyl]-4-(4-methoxyphenyl)-4H-1,2,4-triazole499103-43-4C28H31N3OS
- 3-(4-Chlorophenyl)-4-(4-methylphenyl)-5-((4-nitrobenzyl)thio)-4H-1,2,4-triazole477330-92-0C22H17ClN4O2S
- 3-((3-Chlorobenzyl)thio)-5-(4-chlorophenyl)-4-(4-methylphenyl)-4H-1,2,4-triazole477332-59-5C22H17Cl2N3S
- 3-(4-CL-PH)-5-((3,4-Dichlorobenzyl)thio)-4-(4-methylphenyl)-4H-1,2,4-triazole477332-69-7C22H16Cl3N3S
- 4-(4-Chlorophenyl)-3-(4-methoxyphenyl)-5-((4-nitrobenzyl)thio)-4H-1,2,4-triazole618880-63-0C22H17ClN4O3S
- 3-(2-Chlorophenyl)-5-[(4-nitrophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazole340974-50-7C21H15ClN4O2S
- 3-(4-tert-Butylphenyl)-5-[(2,4-dichlorobenzyl)sulfanyl]-4-(4-methoxyphenyl)-4H-1,2,4-triazole499103-50-3C26H25Cl2N3OS
- 3-[(4-Bromobenzyl)sulfanyl]-5-(4-tert-butylphenyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazole499103-36-5C26H26BrN3OS
- 3-[(4-Bromophenyl)methylsulfanyl]-5-(3-methoxyphenyl)-4-phenyl-1,2,4-triazole331003-16-8C22H18BrN3OS
- (2-Fluorophenyl)methyl 5-(3-fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl sulfide345988-42-3C21H15F2N3S
- 3-[(3-Bromobenzyl)sulfanyl]-5-(3-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole331003-15-7C22H18BrN3OS
- 3-[(2,4-Dimethylphenyl)methylsulfanyl]-4,5-diphenyl-1,2,4-triazole348593-34-0C23H21N3S
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(CSc2nnc(-c3cccnc3)n2-c2ccccc2)cc132 chemicals
c1ccc(CSc2nnc(-c3ccncc3)n2-c2ccccc2)cc130 chemicals![Scaffold O=C(Nc1ccccc1)c1c[nH]c(-c2ccccc2)c1-c1ccccc1](/scaffold/KPRRSDNZJQBLFA-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1c[nH]c(-c2ccccc2)c1-c1ccccc127 chemicals
O=C1NN(C(=O)Nc2ccccc2)C(c2ccccc2)C1c1ccccc13 chemicals![Scaffold O=C(Cn1c(-c2ccccc2)c(-c2ccccc2)[nH]c1=S)c1ccccc1](/scaffold/FDYTZUWLDOIJEA-UHFFFAOYSA-N/structure.svg)
O=C(Cn1c(-c2ccccc2)c(-c2ccccc2)[nH]c1=S)c1ccccc12 chemicals
O=C(Nc1ccccc1)C1NCC(c2ccccc2)C1c1ccccc11 chemical
c1ccc(CSc2nnc(-c3ccccn3)n2-c2ccccc2)cc11 chemical
C(=Nn1cnc(-c2ccccc2)c1-c1ccccc1)c1ccccc11 chemical
c1ccc(-c2nnc(SCC3CCOCO3)n2-c2ccccc2)cc11 chemical