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Murcko scaffold

Ring system with 3 rings and 19 atoms

25 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
25
With full pages
2
Scaffold SMILES

O=C(Nc1cccs1)c1conc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cccs1)c1conc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

Methyl 5-[(dimethylamino)carbonyl]-4-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C21H21N3O5S, CAS 546088-01-1
Methyl 5-[(dimethylamino)carbonyl]-4-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate
CAS 546088-01-1C21H21N3O5S
N-(3-Carbamoyl-4-ethyl-5-methylthiophen-2-yl)-3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H17ClFN3O3S, CAS 445003-56-5
N-(3-Carbamoyl-4-ethyl-5-methylthiophen-2-yl)-3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 445003-56-5C19H17ClFN3O3S
Methyl 4-ethyl-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C20H20N2O4S, CAS 543722-63-0
Methyl 4-ethyl-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate
CAS 543722-63-0C20H20N2O4S
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)-3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C18H15Cl2N3O3S, CAS 544439-49-8
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)-3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 544439-49-8C18H15Cl2N3O3S
Methyl 2-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C19H17ClN2O4S, CAS 441315-51-1
Methyl 2-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-4,5-dimethyl-3-thiophenecarboxylate
CAS 441315-51-1C19H17ClN2O4S
Ethyl 2-({[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-methyl-3-thiophenecarboxylate chemical structure, C19H16ClFN2O4S, CAS 445013-05-8
Ethyl 2-({[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-methyl-3-thiophenecarboxylate
CAS 445013-05-8C19H16ClFN2O4S
Diethyl 5-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C22H21ClN2O6S, CAS 301680-89-7
Diethyl 5-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3-methylthiophene-2,4-dicarboxylate
CAS 301680-89-7C22H21ClN2O6S
N-(3-Carbamoyl-4-ethyl-5-methylthiophen-2-yl)-3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H18ClN3O3S, CAS 352686-16-9
N-(3-Carbamoyl-4-ethyl-5-methylthiophen-2-yl)-3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 352686-16-9C19H18ClN3O3S
Methyl 4-cyano-5-({[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-3-methyl-2-thiophenecarboxylate chemical structure, C19H13Cl2N3O4S, CAS 352692-27-4
Methyl 4-cyano-5-({[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-3-methyl-2-thiophenecarboxylate
CAS 352692-27-4C19H13Cl2N3O4S
Methyl 2-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-[(diethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate chemical structure, C23H24ClN3O5S, CAS 389080-84-6
Methyl 2-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-[(diethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate
CAS 389080-84-6C23H24ClN3O5S
Isopropyl 5-[(dimethylamino)carbonyl]-4-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C23H25N3O5S, CAS 495395-99-8
Isopropyl 5-[(dimethylamino)carbonyl]-4-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate
CAS 495395-99-8C23H25N3O5S
Ethyl 2-({[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-ethyl-3-thiophenecarboxylate chemical structure, C20H18ClFN2O4S, CAS 445037-70-7
Ethyl 2-({[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-ethyl-3-thiophenecarboxylate
CAS 445037-70-7C20H18ClFN2O4S
Isopropyl 2-({[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-[(diethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate chemical structure, C25H27Cl2N3O5S, CAS 353476-00-3
Isopropyl 2-({[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-[(diethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate
CAS 353476-00-3C25H27Cl2N3O5S
Methyl 2-[[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C19H16Cl2N2O4S, CAS 543715-02-2
Methyl 2-[[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-4,5-dimethylthiophene-3-carboxylate
CAS 543715-02-2C19H16Cl2N2O4S
Ethyl 2-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-4-ethyl-5-methylthiophene-3-carboxylate chemical structure, C21H21ClN2O4S, CAS 543712-84-1
Ethyl 2-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-4-ethyl-5-methylthiophene-3-carboxylate
CAS 543712-84-1C21H21ClN2O4S
Propyl 4-ethyl-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C22H24N2O4S, CAS 444928-36-3
Propyl 4-ethyl-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate
CAS 444928-36-3C22H24N2O4S
Ethyl 2-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-isopropyl-3-thiophenecarboxylate chemical structure, C21H21ClN2O4S, CAS 444931-22-0
Ethyl 2-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-5-isopropyl-3-thiophenecarboxylate
CAS 444931-22-0C21H21ClN2O4S
4-Isopropyl 2-methyl 5-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-3-methyl-2,4-thiophenedicarboxylate chemical structure, C22H21ClN2O6S, CAS 444931-23-1
4-Isopropyl 2-methyl 5-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-3-methyl-2,4-thiophenedicarboxylate
CAS 444931-23-1C22H21ClN2O6S
Diisopropyl 3-methyl-5-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-2,4-thiophenedicarboxylate chemical structure, C24H26N2O6S, CAS 544452-00-8
Diisopropyl 3-methyl-5-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-2,4-thiophenedicarboxylate
CAS 544452-00-8C24H26N2O6S
N-(3-Cyanothiophen-2-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C16H11N3O2S, CAS 791126-21-1
N-(3-Cyanothiophen-2-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
CAS 791126-21-1C16H11N3O2S
Isopropyl 4-(aminocarbonyl)-5-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-3-methyl-2-thiophenecarboxylate chemical structure, C21H20ClN3O5S, CAS 438616-13-8
Isopropyl 4-(aminocarbonyl)-5-({[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-3-methyl-2-thiophenecarboxylate
CAS 438616-13-8C21H20ClN3O5S
Methyl 5-methyl-2-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]thiophene-3-carboxylate chemical structure, C18H16N2O4S, CAS 445008-48-0
Methyl 5-methyl-2-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]thiophene-3-carboxylate
CAS 445008-48-0C18H16N2O4S
Dipropan-2-yl 5-[[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C24H24Cl2N2O6S, CAS 438614-44-9
Dipropan-2-yl 5-[[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3-methylthiophene-2,4-dicarboxylate
CAS 438614-44-9C24H24Cl2N2O6S
Methyl 5-isopropyl-2-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C20H20N2O4S, CAS 445020-82-6
Methyl 5-isopropyl-2-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}thiophene-3-carboxylate
CAS 445020-82-6C20H20N2O4S