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Murcko scaffold

Ring system with 3 rings and 19 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
8
With full pages
3
Scaffold SMILES

O=C(Nc1nccs1)c1conc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nccs1)c1conc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

3-(2-Chlorophenyl)-5-methyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C14H10ClN3O2S, CAS 331847-91-7
3-(2-Chlorophenyl)-5-methyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 331847-91-7C14H10ClN3O2S
5-Methyl-3-phenyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C14H11N3O2S, CAS 433237-33-3
5-Methyl-3-phenyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 433237-33-3C14H11N3O2S
3-(2,6-Dichlorophenyl)-5-methyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C14H9Cl2N3O2S, CAS 326902-99-2
3-(2,6-Dichlorophenyl)-5-methyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 326902-99-2C14H9Cl2N3O2S
(2-{[3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-thiazol-4-yl)-acetic acid ethyl ester chemical structure, C18H15Cl2N3O4S, CAS 349613-79-2
(2-{[3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-thiazol-4-yl)-acetic acid ethyl ester
CAS 349613-79-2C18H15Cl2N3O4S
3-(2,6-Dichlorophenyl)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C15H11Cl2N3O2S, CAS 544451-32-3
3-(2,6-Dichlorophenyl)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 544451-32-3C15H11Cl2N3O2S
Ethyl [2-({[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-1,3-thiazol-4-yl]acetate chemical structure, C18H15ClFN3O4S, CAS 444937-03-5
Ethyl [2-({[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl}amino)-1,3-thiazol-4-yl]acetate
CAS 444937-03-5C18H15ClFN3O4S
3-(2-Chlorophenyl)-5-methyl-N-(5-nitro-1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C14H9ClN4O4S, CAS 321532-12-1
3-(2-Chlorophenyl)-5-methyl-N-(5-nitro-1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 321532-12-1C14H9ClN4O4S
Ethyl 2-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)thiazole-4-carboxylate chemical structure, C17H14ClN3O4S, CAS 1170384-17-4
Ethyl 2-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)thiazole-4-carboxylate
CAS 1170384-17-4C17H14ClN3O4S