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Murcko scaffold

Ring system with 3 rings and 19 atoms

19 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 19
With full pages: 10

Scaffold SMILES

O=C(Nc1nncs1)c1conc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1nncs1)c1conc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

3-(2-Chlorophenyl)-5-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-isoxazolecarboxamide chemical structure, C14H11ClN4O2S, CAS 329932-82-3

3-(2-Chlorophenyl)-5-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-isoxazolecarboxamide

CAS 329932-82-3C₁₄H₁₁ClN₄O₂S

5-Methyl-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C17H18N4O2S, CAS 521295-15-8

5-Methyl-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-3-phenyl-1,2-oxazole-4-carboxamide

CAS 521295-15-8C₁₇H₁₈N₄O₂S

5-Methyl-3-phenyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C16H16N4O2S, CAS 524685-86-7

5-Methyl-3-phenyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-1,2-oxazole-4-carboxamide

CAS 524685-86-7C₁₆H₁₆N₄O₂S

3-(2-Chlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C15H13ClN4O2S, CAS 352693-12-0

3-(2-Chlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-5-methyl-1,2-oxazole-4-carboxamide

CAS 352693-12-0C₁₅H₁₃ClN₄O₂S

N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C17H18N4O2S, CAS 432503-50-9

N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide

CAS 432503-50-9C₁₇H₁₈N₄O₂S

N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C15H14N4O2S2, CAS 353790-57-5

N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide

CAS 353790-57-5C₁₅H₁₄N₄O₂S₂

5-Methyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C13H10N4O2S, CAS 545343-02-0

5-Methyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)-1,2-oxazole-4-carboxamide

CAS 545343-02-0C₁₃H₁₀N₄O₂S

N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C15H14N4O2S, CAS 560099-75-4

N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide

CAS 560099-75-4C₁₅H₁₄N₄O₂S

3-(2-Chlorophenyl)-5-methyl-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-1,2-oxazole-4-carboxamide chemical structure, C17H17ClN4O2S, CAS 590398-68-8

3-(2-Chlorophenyl)-5-methyl-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-1,2-oxazole-4-carboxamide

CAS 590398-68-8C₁₇H₁₇ClN₄O₂S

3-(2-Chlorophenyl)-N-[5-(ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C15H13ClN4O2S2, CAS 312952-07-1

3-(2-Chlorophenyl)-N-[5-(ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 312952-07-1C₁₅H₁₃ClN₄O₂S₂

3-(2-Chlorophenyl)-5-methyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-4-isoxazolecarboxamide chemical structure, C16H15ClN4O2S, CAS 391864-22-5

3-(2-Chlorophenyl)-5-methyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-4-isoxazolecarboxamide

CAS 391864-22-5C₁₆H₁₅ClN₄O₂S

3-(2,6-Dichlorophenyl)-N-[5-(ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C15H12Cl2N4O2S2, CAS 5701-55-3

3-(2,6-Dichlorophenyl)-N-[5-(ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 5701-55-3C₁₅H₁₂Cl₂N₄O₂S₂

N-[5-(Ethoxymethyl)-1,3,4-thiadiazol-2-yl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C16H16N4O3S, CAS 701226-86-0

N-[5-(Ethoxymethyl)-1,3,4-thiadiazol-2-yl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide

CAS 701226-86-0C₁₆H₁₆N₄O₃S

N-(5-(Butylthio)-1,3,4-thiadiazol-2-yl)-3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamide chemical structure, C17H17ClN4O2S2, CAS 391875-88-0

N-(5-(Butylthio)-1,3,4-thiadiazol-2-yl)-3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamide

CAS 391875-88-0C₁₇H₁₇ClN₄O₂S₂

Ethyl 2-((5-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetate chemical structure, C17H15ClN4O4S2, CAS 391874-83-2

Ethyl 2-((5-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetate

CAS 391874-83-2C₁₇H₁₅ClN₄O₄S₂

3-(2-Chlorophenyl)-5-methyl-N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)isoxazole-4-carboxamide chemical structure, C14H11ClN4O2S2, CAS 391875-73-3

3-(2-Chlorophenyl)-5-methyl-N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)isoxazole-4-carboxamide

CAS 391875-73-3C₁₄H₁₁ClN₄O₂S₂

3-(2-Chlorophenyl)-5-methyl-N-(5-(propylthio)-1,3,4-thiadiazol-2-yl)isoxazole-4-carboxamide chemical structure, C16H15ClN4O2S2, CAS 391875-20-0

3-(2-Chlorophenyl)-5-methyl-N-(5-(propylthio)-1,3,4-thiadiazol-2-yl)isoxazole-4-carboxamide

CAS 391875-20-0C₁₆H₁₅ClN₄O₂S₂

3-(2-Chlorophenyl)-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C15H13ClN4O3S, CAS 885660-47-9

3-(2-Chlorophenyl)-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 885660-47-9C₁₅H₁₃ClN₄O₃S

3-(2-Chloro-6-fluorophenyl)-5-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C14H10ClFN4O2S, CAS 925199-86-6

3-(2-Chloro-6-fluorophenyl)-5-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-1,2-oxazole-4-carboxamide

CAS 925199-86-6C₁₄H₁₀ClFN₄O₂S