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Murcko scaffold

Ring system with 3 rings and 25 atoms

46 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
46
With full pages
10
Scaffold SMILES

O=C(NC(=Cc1ccccc1)C(=O)N1CCCCC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC(=Cc1ccccc1)C(=O)N1CCCCC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 46 of 46 chemicals

Benzamide, N-(2-phenyl-1-(1-piperidinylcarbonyl)ethenyl)-, (E)- chemical structure, C21H22N2O2, CAS 38879-55-9
Benzamide, N-(2-phenyl-1-(1-piperidinylcarbonyl)ethenyl)-, (E)-
CAS 38879-55-9C21H22N2O2
Benzamide, N-(2-(4-(dimethylamino)phenyl)-1-(1-piperidinylcarbonyl)ethenyl)-, (E)- chemical structure, C23H27N3O2, CAS 51921-68-7
Benzamide, N-(2-(4-(dimethylamino)phenyl)-1-(1-piperidinylcarbonyl)ethenyl)-, (E)-
CAS 51921-68-7C23H27N3O2
(E)-N-(1-(4-Methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide chemical structure, C22H24N2O3, CAS 201989-25-5
(E)-N-(1-(4-Methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide
CAS 201989-25-5C22H24N2O3
4-Nitro-N-(2-phenyl-1-(piperidine-1-carbonyl)-vinyl)-benzamide chemical structure, C21H21N3O4, CAS 297146-14-6
4-Nitro-N-(2-phenyl-1-(piperidine-1-carbonyl)-vinyl)-benzamide
CAS 297146-14-6C21H21N3O4
N-[(E)-1-(3,4-Dimethoxyphenyl)-3-oxo-3-piperidin-1-ylprop-1-en-2-yl]-4-methylbenzamide chemical structure, C24H28N2O4, CAS 381189-59-9
N-[(E)-1-(3,4-Dimethoxyphenyl)-3-oxo-3-piperidin-1-ylprop-1-en-2-yl]-4-methylbenzamide
CAS 381189-59-9C24H28N2O4
N-{2-{4-Nitrophenyl}-1-[(4-methyl-1-piperidinyl)carbonyl]vinyl}-4-methylbenzamide chemical structure, C23H25N3O4, CAS 331430-53-6
N-{2-{4-Nitrophenyl}-1-[(4-methyl-1-piperidinyl)carbonyl]vinyl}-4-methylbenzamide
CAS 331430-53-6C23H25N3O4
4-Acetylamino-N-[2-phenyl-1-(piperidine-1-carbonyl)-vinyl]-benzamide chemical structure, C23H25N3O3, CAS 102559-59-1
4-Acetylamino-N-[2-phenyl-1-(piperidine-1-carbonyl)-vinyl]-benzamide
CAS 102559-59-1C23H25N3O3
N-[(E)-1-(4-Bromophenyl)-3-oxo-3-piperidin-1-ylprop-1-en-2-yl]-2-fluorobenzamide chemical structure, C21H20BrFN2O2, CAS 381692-13-3
N-[(E)-1-(4-Bromophenyl)-3-oxo-3-piperidin-1-ylprop-1-en-2-yl]-2-fluorobenzamide
CAS 381692-13-3C21H20BrFN2O2
AT 61 chemical structure, C21H21ClN2O2, CAS 300669-68-5
AT 61
CAS 300669-68-5C21H21ClN2O2
N-[(E)-2-Chloro-2-(4-chlorophenyl)-1-(piperidine-1-carbonyl)vinyl]benzamide chemical structure, C21H20Cl2N2O2, CAS 211364-16-8
N-[(E)-2-Chloro-2-(4-chlorophenyl)-1-(piperidine-1-carbonyl)vinyl]benzamide
CAS 211364-16-8C21H20Cl2N2O2
N-[(1e)-1-Bromo-1-(2-Methoxyphenyl)-3-Oxo-3-(Piperidin-1-Yl)prop-1-En-2-Yl]-4-Nitrobenzamide chemical structure, C22H22BrN3O5, CAS 211364-06-6
N-[(1e)-1-Bromo-1-(2-Methoxyphenyl)-3-Oxo-3-(Piperidin-1-Yl)prop-1-En-2-Yl]-4-Nitrobenzamide
CAS 211364-06-6C22H22BrN3O5
N-[1-(4-Methyl-piperidine-1-carbonyl)-2-phenyl-vinyl]-benzamide chemical structure, C22H24N2O2, CAS 297145-92-7
N-[1-(4-Methyl-piperidine-1-carbonyl)-2-phenyl-vinyl]-benzamide
CAS 297145-92-7C22H24N2O2
4-Chloro-N-[(E)-1-(4-methoxyphenyl)-3-(4-methylpiperidin-1-yl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C23H25ClN2O3, CAS 383900-57-0
4-Chloro-N-[(E)-1-(4-methoxyphenyl)-3-(4-methylpiperidin-1-yl)-3-oxoprop-1-en-2-yl]benzamide
CAS 383900-57-0C23H25ClN2O3
Benzamide, 4-(acetylamino)-N-(2-(4-chlorophenyl)-1-(1-piperidinylcarbonyl)ethenyl)-, (E)- chemical structure, C23H24ClN3O3, CAS 51896-14-1
Benzamide, 4-(acetylamino)-N-(2-(4-chlorophenyl)-1-(1-piperidinylcarbonyl)ethenyl)-, (E)-
CAS 51896-14-1C23H24ClN3O3
(Z)-N-(1-Chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide chemical structure, C21H21ClN2O2, CAS 265977-72-8
(Z)-N-(1-Chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide
CAS 265977-72-8C21H21ClN2O2
(Z)-N-(1-Chloro-3-oxo-3-(piperidin-1-yl)-1-(p-tolyl)prop-1-en-2-yl)benzamide chemical structure, C22H23ClN2O2, CAS 1323140-63-1
(Z)-N-(1-Chloro-3-oxo-3-(piperidin-1-yl)-1-(p-tolyl)prop-1-en-2-yl)benzamide
CAS 1323140-63-1C22H23ClN2O2
(Z)-N-(1-Chloro-1-(2-methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide chemical structure, C22H23ClN2O3, CAS 1323140-58-4
(Z)-N-(1-Chloro-1-(2-methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide
CAS 1323140-58-4C22H23ClN2O3
(Z)-N-(1-Chloro-1-(2-fluorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide chemical structure, C21H20ClFN2O2, CAS 1323140-60-8
(Z)-N-(1-Chloro-1-(2-fluorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide
CAS 1323140-60-8C21H20ClFN2O2
(Z)-N-(1-Bromo-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide chemical structure, C21H21BrN2O2, CAS 705293-97-6
(Z)-N-(1-Bromo-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide
CAS 705293-97-6C21H21BrN2O2
(Z)-N-(1-Chloro-1-(4-chlorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide chemical structure, C21H20Cl2N2O2, CAS 1323140-62-0
(Z)-N-(1-Chloro-1-(4-chlorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide
CAS 1323140-62-0C21H20Cl2N2O2
(Z)-N-(1-Chloro-3-oxo-3-(piperidin-1-yl)-1-(o-tolyl)prop-1-en-2-yl)benzamide chemical structure, C22H23ClN2O2, CAS 1323140-59-5
(Z)-N-(1-Chloro-3-oxo-3-(piperidin-1-yl)-1-(o-tolyl)prop-1-en-2-yl)benzamide
CAS 1323140-59-5C22H23ClN2O2
N-[(Z)-2-Chloro-2-phenyl-1-(piperidine-1-carbonyl)vinyl]-4-nitro-benzamide chemical structure, C21H20ClN3O4, CAS 1323140-65-3
N-[(Z)-2-Chloro-2-phenyl-1-(piperidine-1-carbonyl)vinyl]-4-nitro-benzamide
CAS 1323140-65-3C21H20ClN3O4
4-Cyano-N-[3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl]benzamide chemical structure, C22H21N3O2, CAS 90290-92-9
4-Cyano-N-[3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl]benzamide
CAS 90290-92-9C22H21N3O2
N-[1-(4-Cyanophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl]benzamide chemical structure, C22H21N3O2, CAS 90290-85-0
N-[1-(4-Cyanophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl]benzamide
CAS 90290-85-0C22H21N3O2