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Murcko scaffold

Ring system with 3 rings and 25 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
14
With full pages
8
Scaffold SMILES

O=C(NC(=Cc1ccccc1)C(=O)N1CCNCC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC(=Cc1ccccc1)C(=O)N1CCNCC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

N-[(Z)-1-(4-Fluorophenyl)-3-(4-methylpiperazin-1-yl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C21H22FN3O2, CAS 332168-19-1
N-[(Z)-1-(4-Fluorophenyl)-3-(4-methylpiperazin-1-yl)-3-oxoprop-1-en-2-yl]benzamide
CAS 332168-19-1C21H22FN3O2
2-Chloro-N-[(Z)-1-(4-fluorophenyl)-3-(4-methylpiperazin-1-yl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C21H21ClFN3O2, CAS 376606-49-4
2-Chloro-N-[(Z)-1-(4-fluorophenyl)-3-(4-methylpiperazin-1-yl)-3-oxoprop-1-en-2-yl]benzamide
CAS 376606-49-4C21H21ClFN3O2
N-[2-(2-Fluoro-phenyl)-1-(4-methyl-piperazine-1-carbonyl)-vinyl]-benzamide chemical structure, C21H22FN3O2, CAS 5910-07-6
N-[2-(2-Fluoro-phenyl)-1-(4-methyl-piperazine-1-carbonyl)-vinyl]-benzamide
CAS 5910-07-6C21H22FN3O2
Ethyl 4-[2-benzamido-3-(2-chlorophenyl)prop-2-enoyl]piperazine-1-carboxylate chemical structure, C23H24ClN3O4, CAS 4329-20-8
Ethyl 4-[2-benzamido-3-(2-chlorophenyl)prop-2-enoyl]piperazine-1-carboxylate
CAS 4329-20-8C23H24ClN3O4
N-[(E)-1-(4-Hydroxyphenyl)-3-(4-methylpiperazin-1-yl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C21H23N3O3, CAS 5907-92-6
N-[(E)-1-(4-Hydroxyphenyl)-3-(4-methylpiperazin-1-yl)-3-oxoprop-1-en-2-yl]benzamide
CAS 5907-92-6C21H23N3O3
N-[(E)-3-(4-Methylpiperazin-1-yl)-1-(4-methylsulfanylphenyl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C22H25N3O2S, CAS 342382-72-3
N-[(E)-3-(4-Methylpiperazin-1-yl)-1-(4-methylsulfanylphenyl)-3-oxoprop-1-en-2-yl]benzamide
CAS 342382-72-3C22H25N3O2S
4-[2-Benzoylamino-3-(4-methoxy-phenyl)-acryloyl]-piperazine-1-carboxylic acid ethyl ester chemical structure, C24H27N3O5, CAS 5903-92-4
4-[2-Benzoylamino-3-(4-methoxy-phenyl)-acryloyl]-piperazine-1-carboxylic acid ethyl ester
CAS 5903-92-4C24H27N3O5
Bas 01217449 chemical structure, C25H29N3O6, CAS 5907-54-0
Bas 01217449
CAS 5907-54-0C25H29N3O6
(Z)-Ethyl 4-(2-benzamido-3-(4-(dimethylamino)phenyl)acryloyl)piperazine-1-carboxylate chemical structure, C25H30N4O4, CAS 327081-84-5
(Z)-Ethyl 4-(2-benzamido-3-(4-(dimethylamino)phenyl)acryloyl)piperazine-1-carboxylate
CAS 327081-84-5C25H30N4O4
N-[2-(4-Dimethylamino-phenyl)-1-(4-methyl-piperazine-1-carbonyl)-vinyl]-benzamide chemical structure, C23H28N4O2, CAS 332168-21-5
N-[2-(4-Dimethylamino-phenyl)-1-(4-methyl-piperazine-1-carbonyl)-vinyl]-benzamide
CAS 332168-21-5C23H28N4O2
(Z)-Ethyl 4-(2-benzamido-3-(4-fluorophenyl)acryloyl)piperazine-1-carboxylate chemical structure, C23H24FN3O4, CAS 374091-68-6
(Z)-Ethyl 4-(2-benzamido-3-(4-fluorophenyl)acryloyl)piperazine-1-carboxylate
CAS 374091-68-6C23H24FN3O4
(Z)-Ethyl 4-(2-benzamido-3-(2-fluorophenyl)acryloyl)piperazine-1-carboxylate chemical structure, C23H24FN3O4, CAS 372970-63-3
(Z)-Ethyl 4-(2-benzamido-3-(2-fluorophenyl)acryloyl)piperazine-1-carboxylate
CAS 372970-63-3C23H24FN3O4
(Z)-Ethyl 4-(2-benzamido-3-(2-chlorophenyl)acryloyl)piperazine-1-carboxylate chemical structure, C23H24ClN3O4, CAS 374550-24-0
(Z)-Ethyl 4-(2-benzamido-3-(2-chlorophenyl)acryloyl)piperazine-1-carboxylate
CAS 374550-24-0C23H24ClN3O4
(E)-Ethyl 4-(2-benzamido-3-(4-(methylthio)phenyl)acryloyl)piperazine-1-carboxylate chemical structure, C24H27N3O4S, CAS 375828-53-8
(E)-Ethyl 4-(2-benzamido-3-(4-(methylthio)phenyl)acryloyl)piperazine-1-carboxylate
CAS 375828-53-8C24H27N3O4S