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Murcko scaffold

Ring system with 3 rings and 25 atoms

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
15
With full pages
5
Scaffold SMILES

O=C(NC(=Cc1ccccc1)C(=O)N1CCOCC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC(=Cc1ccccc1)C(=O)N1CCOCC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

Benzamide, N-(2-(2-chlorophenyl)-1-(4-morpholinylcarbonyl)ethenyl)-, (E)- chemical structure, C20H19ClN2O3, CAS 51896-15-2
Benzamide, N-(2-(2-chlorophenyl)-1-(4-morpholinylcarbonyl)ethenyl)-, (E)-
CAS 51896-15-2C20H19ClN2O3
4-Methyl-N-(1-(4-morpholinylcarbonyl)-2-(3-nitrophenyl)vinyl)benzamide chemical structure, C21H21N3O5, CAS 413609-92-4
4-Methyl-N-(1-(4-morpholinylcarbonyl)-2-(3-nitrophenyl)vinyl)benzamide
CAS 413609-92-4C21H21N3O5
N-[(1Z)-1-(2-Methoxyphenyl)-3-(morpholin-4-yl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C21H22N2O4, CAS 304001-30-7
N-[(1Z)-1-(2-Methoxyphenyl)-3-(morpholin-4-yl)-3-oxoprop-1-en-2-yl]benzamide
CAS 304001-30-7C21H22N2O4
N-[(E)-1-(4-Methylsulfanylphenyl)-3-morpholin-4-yl-3-oxoprop-1-en-2-yl]benzamide chemical structure, C21H22N2O3S, CAS 375355-46-7
N-[(E)-1-(4-Methylsulfanylphenyl)-3-morpholin-4-yl-3-oxoprop-1-en-2-yl]benzamide
CAS 375355-46-7C21H22N2O3S
(E)-N-(1-(4-Chlorophenyl)-3-morpholino-3-oxoprop-1-en-2-yl)benzamide chemical structure, C20H19ClN2O3, CAS 202342-17-4
(E)-N-(1-(4-Chlorophenyl)-3-morpholino-3-oxoprop-1-en-2-yl)benzamide
CAS 202342-17-4C20H19ClN2O3
N-[2-(4-Fluoro-phenyl)-1-(morpholine-4-carbonyl)-vinyl]-benzamide chemical structure, C20H19FN2O3, CAS 201989-28-8
N-[2-(4-Fluoro-phenyl)-1-(morpholine-4-carbonyl)-vinyl]-benzamide
CAS 201989-28-8C20H19FN2O3
2,4-Dichloro-N-[(1E)-3-(2,6-dimethylmorpholin-4-yl)-1-(4-methoxyphenyl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C23H24Cl2N2O4, CAS 384799-67-1
2,4-Dichloro-N-[(1E)-3-(2,6-dimethylmorpholin-4-yl)-1-(4-methoxyphenyl)-3-oxoprop-1-en-2-yl]benzamide
CAS 384799-67-1C23H24Cl2N2O4
(E)-N-(3-Morpholino-1-(3-nitrophenyl)-3-oxoprop-1-en-2-yl)benzamide chemical structure, C20H19N3O5, CAS 313959-98-7
(E)-N-(3-Morpholino-1-(3-nitrophenyl)-3-oxoprop-1-en-2-yl)benzamide
CAS 313959-98-7C20H19N3O5
Benzamide, N-(1-(4-morpholinylcarbonyl)-2-phenylethenyl)-, (E)- chemical structure, C20H20N2O3, CAS 38879-56-0
Benzamide, N-(1-(4-morpholinylcarbonyl)-2-phenylethenyl)-, (E)-
CAS 38879-56-0C20H20N2O3
Benzamide, 4-(acetylamino)-N-(2-(4-methoxyphenyl)-1-(4-morpholinylcarbonyl)ethenyl)-, (E)- chemical structure, C23H25N3O5, CAS 51896-16-3
Benzamide, 4-(acetylamino)-N-(2-(4-methoxyphenyl)-1-(4-morpholinylcarbonyl)ethenyl)-, (E)-
CAS 51896-16-3C23H25N3O5
Benzamide, 4-(acetylamino)-N-(2-(4-(dimethylamino)phenyl)-1-(4-morpholinylcarbonyl)ethenyl)-,(E)- chemical structure, C24H28N4O4, CAS 51896-17-4
Benzamide, 4-(acetylamino)-N-(2-(4-(dimethylamino)phenyl)-1-(4-morpholinylcarbonyl)ethenyl)-,(E)-
CAS 51896-17-4C24H28N4O4
N-[(1Z)-1-(2-Fluorophenyl)-3-(morpholin-4-yl)-3-oxoprop-1-en-2-yl]-4-methylbenzamide chemical structure, C21H21FN2O3, CAS 300405-20-3
N-[(1Z)-1-(2-Fluorophenyl)-3-(morpholin-4-yl)-3-oxoprop-1-en-2-yl]-4-methylbenzamide
CAS 300405-20-3C21H21FN2O3
4-Cyano-N-[3-(morpholin-4-yl)-3-oxo-1-phenylprop-1-en-2-yl]benzamide chemical structure, C21H19N3O3, CAS 90290-95-2
4-Cyano-N-[3-(morpholin-4-yl)-3-oxo-1-phenylprop-1-en-2-yl]benzamide
CAS 90290-95-2C21H19N3O3
N-[1-(4-Cyanophenyl)-3-(morpholin-4-yl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C21H19N3O3, CAS 90290-91-8
N-[1-(4-Cyanophenyl)-3-(morpholin-4-yl)-3-oxoprop-1-en-2-yl]benzamide
CAS 90290-91-8C21H19N3O3
4-Chloro-N-[3-(morpholin-4-yl)-3-oxo-1-phenylprop-1-en-2-yl]benzamide chemical structure, C20H19ClN2O3, CAS 90125-04-5
4-Chloro-N-[3-(morpholin-4-yl)-3-oxo-1-phenylprop-1-en-2-yl]benzamide
CAS 90125-04-5C20H19ClN2O3