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Murcko scaffold

1-[1-(Benzenesulfonyl)piperidin-4-yl]-4-phenylpiperazine scaffold

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
12
With full pages
3
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCC(N2CCN(c3ccccc3)CC2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-[1-(Benzenesulfonyl)piperidin-4-yl]-4-phenylpiperazine page
Murcko scaffold O=S(=O)(c1ccccc1)N1CCC(N2CCN(c3ccccc3)CC2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

1-[1-(Benzenesulfonyl)piperidin-4-yl]-4-phenylpiperazine chemical structure, C21H27N3O2S, CAS 489416-59-3
1-[1-(Benzenesulfonyl)piperidin-4-yl]-4-phenylpiperazine
CAS 489416-59-3C21H27N3O2S
1-[1-(4-Chlorophenyl)sulfonylpiperidin-4-yl]-4-(2-methoxyphenyl)piperazine chemical structure, C22H28ClN3O3S, CAS 431998-17-3
1-[1-(4-Chlorophenyl)sulfonylpiperidin-4-yl]-4-(2-methoxyphenyl)piperazine
CAS 431998-17-3C22H28ClN3O3S
1-{1-[(4-Fluorophenyl)sulfonyl]-4-piperidinyl}-4-phenylpiperazine chemical structure, C21H26FN3O2S, CAS 496799-80-5
1-{1-[(4-Fluorophenyl)sulfonyl]-4-piperidinyl}-4-phenylpiperazine
CAS 496799-80-5C21H26FN3O2S
1-[1-(4-Methylphenyl)sulfonylpiperidin-4-yl]-4-phenylpiperazine chemical structure, C22H29N3O2S, CAS 489443-73-4
1-[1-(4-Methylphenyl)sulfonylpiperidin-4-yl]-4-phenylpiperazine
CAS 489443-73-4C22H29N3O2S
1-(2-Fluorophenyl)-4-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]piperazine chemical structure, C22H28FN3O3S, CAS 792928-00-8
1-(2-Fluorophenyl)-4-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]piperazine
CAS 792928-00-8C22H28FN3O3S
1-[1-(4-Chlorophenyl)sulfonylpiperidin-4-yl]-4-phenylpiperazine chemical structure, C21H26ClN3O2S, CAS 488851-83-8
1-[1-(4-Chlorophenyl)sulfonylpiperidin-4-yl]-4-phenylpiperazine
CAS 488851-83-8C21H26ClN3O2S
1-[1-(4-Fluorophenyl)sulfonylpiperidin-4-yl]-4-(2-methoxyphenyl)piperazine chemical structure, C22H28FN3O3S, CAS 431985-59-0
1-[1-(4-Fluorophenyl)sulfonylpiperidin-4-yl]-4-(2-methoxyphenyl)piperazine
CAS 431985-59-0C22H28FN3O3S
1-(2-Methoxyphenyl)-4-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]piperazine chemical structure, C23H31N3O3S, CAS 487036-08-8
1-(2-Methoxyphenyl)-4-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]piperazine
CAS 487036-08-8C23H31N3O3S
1-(2-Methoxyphenyl)-4-{1-[(4-methoxyphenyl)sulfonyl]-4-piperidinyl}piperazine chemical structure, C23H31N3O4S, CAS 431984-84-8
1-(2-Methoxyphenyl)-4-{1-[(4-methoxyphenyl)sulfonyl]-4-piperidinyl}piperazine
CAS 431984-84-8C23H31N3O4S
1-{1-[(4-Methoxyphenyl)sulfonyl]-4-piperidinyl}-4-phenylpiperazine chemical structure, C22H29N3O3S, CAS 488134-82-3
1-{1-[(4-Methoxyphenyl)sulfonyl]-4-piperidinyl}-4-phenylpiperazine
CAS 488134-82-3C22H29N3O3S
N-[4-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]sulfonylphenyl]acetamide chemical structure, C24H32N4O4S, CAS 792926-78-4
N-[4-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]sulfonylphenyl]acetamide
CAS 792926-78-4C24H32N4O4S
N-{3-Methyl-4-[(4-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}piperidin-1-yl)sulfonyl]phenyl}acetamide chemical structure, C25H31F3N4O3S, CAS 2097934-58-0
N-{3-Methyl-4-[(4-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}piperidin-1-yl)sulfonyl]phenyl}acetamide
CAS 2097934-58-0C25H31F3N4O3S